Majalah Kedokteran Bandung, 2017 Indonesia is the second highest country with TB patients in the world. Diabetes mellitus (DM) is a comorbid of TB. Arylamine N-acetyltransferase 2 (NAT2), encoded by the NAT2 gene, is an enzyme that metabolizes isoniazid (INH).
Alvinsyah Adhityo Pramono +5 more
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Liver-Selective Expression of Human Arylamine N-Acetyltransferase NAT2 in Transgenic Mice [PDF]
, 2011 Human arylamine N-acetyltransferase 2 (NAT2) mediates the bio-transformation of arylamine drugs and procarcinogens into either innocuous or reactive DNA-damaging metabolites and is ex-pressed predominantly in liver.
Debbie Brenneman +2 more
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BMC Medical Genetics, 2004 Background Alzheimer's disease is multifactorial, having environmental, toxicological and genetic risk factors. Impaired folate and homocysteine metabolism has been hypothesised to increase risk. In addition to its xenobiotic-metabolising capacity, human
Budge Marc +4 more
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Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.
Journal of Biological Chemistry, 1984 Amine N-acetylation in the pineal gland is of special importance because it is the first step in the synthesis of melatonin from serotonin. In the present study the N-acetylation of arylamines and arylalkylamines by homogenates of rat and sheep pineal glands was investigated.
P, Voisin, M A, Namboodiri, D C, Klein
openaire +2 more sources
Interaction of human arylamine n-acetyltransferase 1 with different nanomaterials [PDF]
, 2014 Humans are exposed to nanoparticles in the environment as well as those in nanomaterials developed for biomedical applications. However, the safety and biologic effects of many nanoparticles remain to be elucidated.
Mortimer, Gysell M. +6 more
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Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study. [PDF]
In Vivo, 2023 Hernandez-Gonzalez O +8 more
europepmc +1 more source
Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase [PDF]
, 2005 The gene for NAT (arylamine N-acetyltransferase) from Pseudomonas aeruginosa (panat) has been cloned from genomic DNA, and the gene product (PANAT) expressed as an N-terminal histidine-tagged protein in Escherichia coli and purified via nickel ion ...
Holton, Simon J. +12 more
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Assessment of arylamine N-acetyltransferase (NAT1) activity in mononuclear leukocytes of cystic fibrosis patients [PDF]
The clearance of sulphamethoxazole (SMX), a compound metabolised primarily by the N-acetyltransferase NAT1, is increased in cystic fibrosis (CF) patients.
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Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms
Toxicology, 2008 Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines and arylhydrazines with the acetyl group being transferred from acetylCoenzyme A. As a result of many recent advances in NAT research there have been many recent reviews and the present paper gives a flavour of the excitement in the field. The NATs, which
Sim, E +6 more
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Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells [PDF]
, 2007 Human arylamine N-acetyltransferases (NAT) bioactivate arylamine and heterocyclic amine carcinogens present in red meat and tobacco products. As a result, factors that regulate expression of NATs have the potential to modulate cancer risk in individuals ...
Minchin, Rodney F. +4 more
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