Results 91 to 100 of about 13,476,144 (183)

Deletion of the benzoxazinoid detoxification gene NAT1 in Fusarium graminearum reduces deoxynivalenol in spring wheat.

PLoS ONE, 2019
Benzoxazinoid (Bx) metabolites produced by wheat and other members of the Poaceae have activity against Fusarium sp. that cause cereal diseases including Fusarium head blight (FHB) on wheat and barley. Certain Bx metabolites can be detoxified by Fusarium
Thomas Baldwin, Suzette Baldwin, Kathy Klos, Phil Bregitzer, Juliet Marshall   +4 more
doaj   +1 more source

Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms

Toxicology, 2008
Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines and arylhydrazines with the acetyl group being transferred from acetylCoenzyme A. As a result of many recent advances in NAT research there have been many recent reviews and the present paper gives a flavour of the excitement in the field. The NATs, which
Sim, E, Lack, N, Wang, C, Long, H, Westwood, I, Fullam, E, Kawamura, A   +6 more
openaire   +3 more sources

Thiolsubtilisin acts as an acetyltransferase in organic solvents [PDF]

, 2002
The catalytic mechanism of arylamine N-acetyltransferase has been proposed to involve Cys-His-Asp as its catalytic triad. Thiolsubtilisin, a chemically modified enzyme that has a catalytic triad of Cys-His-Asp at the active site, mimics the catalysis of ...
Dar-Fu Tai, Tai, Dar-Fu, Wen-Chen Liaw, Liaw, Wen-Chen   +3 more
core   +1 more source

Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review. [PDF]

Expert Opin Drug Metab Toxicol, 2021
Hein DW, Millner LM.
europepmc   +1 more source

Electrochemical late-stage modification of hydralazine an antihypertensive drug. A green strategy for the synthesis of nano-structured new sulfonylhydrazine derivatives

Green Synthesis and Catalysis
This work is focused on the electrochemical late-stage modification of hydralazine (1-hydrazinylphthalazine) (HYD), a common antihypertensive drug, and the synthesis of its new sulfonylhydrazine derivatives.
Farideh Lotfipour, Davood Nematollahi, Niloofar Mohamadighader, Zahra Godini   +3 more
doaj   +1 more source

Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis. [PDF]

Mol Carcinog, 2022
Doll MA, Ray AR, Salazar-González RA, Shah PP, Vega AA, Sears SM, Krueger AM, Hong KU, Beverly LJ, Hein DW.   +9 more
europepmc   +1 more source

Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes

, 1991
The expression of arylamine N-acetyltransferase (NAT) in leukocytes was investigated using p-aminobenzoic acid (PABA) and sulfamethazine (SMZ), substrates which are preferentially acetylated by the monomorphic NAT1 and polymorphic NAT2 enzymes ...

core  

N-acetyltransferase polymorphism in patients with Behcet's disease

, 2001
Objectives: The objective of our study was to investigate the possible role of human arylamine N-acetyltransferase 2 (NAT2) polymorphism in susceptibility to Behcet's ...
Aynacioglu, AS, Kayaalp, SO, Tunc, R, Dincel, A, Bozkurt, A, Kortunay, S, Nacak, M   +6 more
core   +1 more source

Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes

The purpose of this study was to determine the molecular basis in the dog for an unusual and absolute deficiency in the activity of cytosolic N-acetyltransferase (NAT), an enzyme important for the metabolism of arylamine and hydrazine compounds.

core   +1 more source

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2. [PDF]

Angew Chem Int Ed Engl, 2020
Conway LP, Rendo V, Correia MSP, Bergdahl IA, Sjöblom T, Globisch D.   +5 more
europepmc   +1 more source