Results 111 to 120 of about 2,402 (195)

Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa [PDF]

, 2013
Includes abstract.Includes bibliographical references.Oesophageal squamous cell carcinoma (OSCC) is a complex disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring
Matejcic, Marco
core  

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2. [PDF]

Angew Chem Int Ed Engl, 2020
Conway LP, Rendo V, Correia MSP, Bergdahl IA, Sjöblom T, Globisch D.   +5 more
europepmc   +1 more source

Structure of Mesorhizobium loti arylamine N-acetyltransferase 1 [PDF]

The arylamine N-acetyltransferase (NAT) enzymes have been found in a broad range of both eukaryotic and prokaryotic organisms. The NAT enzymes catalyse the transfer of an acetyl group from acetyl Co-enzyme A onto the terminal nitrogen of a range of ...
Dairou J, Noble MEM, Sandy J, Rodrigues-Lima F, Holton SJ, Dupret JM, Sim E   +6 more
core  

NAT2 gene polymorphisms and plasma isoniazid concentration in Vietnamese tuberculosis patients

Walailak Journal of Science and Technology, 2019
Background: Isoniazid (INH) is one of the most common drug for tuberculosis (TB) treatment and INH acetylation catalysed by non-inducible hepatic enzyme arylamine N-acetyltransferase type 2 (NAT2).
Anh Tuan Le, Nhung Hong Thi Pham, Long Doan Dinh, Luyen Thi Le, Thom Thi Vu   +4 more
doaj  

Pharmacogenomic heterogeneity of N-acetyltransferase 2: a comprehensive analysis of real world data in Indian tuberculosis patients and from literature and database review

Annals of Medicine
Background Isoniazid is primarily metabolized by the arylamine N-acetyltransferase 2 (NAT2) enzyme. Single nucleotide polymorphisms (SNPs) in the NAT2 gene could classify an individual into three distinct phenotypes: rapid, intermediate and slow ...
Levin Thomas, Chaithra, Yashi Batra, Mitali Mathur, Shrivathsa Kulavalli, Chidananda Sanju SV, Naveen Dutt, Pankaj Bhardwaj, Muralidhar Varma, Kavitha Saravu, Mithu Banerjee, Mahadev Rao   +11 more
doaj   +1 more source

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes. [PDF]

Sci Rep, 2020
Salazar-González RA, Doll MA, Hein DW.
europepmc   +1 more source

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer

Genetics and Molecular Biology, 2012
The arylamine N-acetyltransferase 2 (NAT2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. Point mutations in the NAT2 gene result in the variant alleles M1 (NAT2 *5A), M2 (NAT2*6A), M3 (NAT2*7) and M4 ...
Amjad Mahasneh, Amal Jubaili, Ahmed El Bateiha, Mohammad Al-Ghazo, Ismail Matalka, Mousa Malkawi   +5 more
doaj  

Mapping the genes for arylamine N-acetyltransferases

, 2000
Arylamine N-acetyltransferases are xenobiotic metabolising enzymes, involved in metabolic pathways leading to either detoxification or bio-activation of drugs and carcinogens. In humans, polymorphisms of the two functional NAT genes (NAT1 and NAT2} have been implicated to cancer susceptibility.
openaire   +2 more sources

Investigating the mechanisms by which low NAT1 expression in tumor cells contributes to chemo-resistance in colorectal cancer

Clinical Epigenetics
Background In the therapeutic landscape of colorectal cancer (CRC), chemo-resistance poses a significant and prevalent obstacle that complicates treatment efficacy and patient outcomes.
Zheng Yuan, Kai Fang, Xinsheng Miao, Yan Zhang, Menghui Gu, Wei Xu, Hao Li, Dawei Zhu, Jiahui Zhou, Jian Sun, Xinhua Gu   +10 more
doaj   +1 more source

CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. [PDF]

Sci Rep, 2020
Carlisle SM, Trainor PJ, Hong KU, Doll MA, Hein DW.   +4 more
europepmc   +1 more source