Results 101 to 110 of about 13,476,144 (183)

NAT2 gene polymorphisms and plasma isoniazid concentration in Vietnamese tuberculosis patients

Walailak Journal of Science and Technology, 2019
Background: Isoniazid (INH) is one of the most common drug for tuberculosis (TB) treatment and INH acetylation catalysed by non-inducible hepatic enzyme arylamine N-acetyltransferase type 2 (NAT2).
Anh Tuan Le, Nhung Hong Thi Pham, Long Doan Dinh, Luyen Thi Le, Thom Thi Vu   +4 more
doaj  

Changes in consensus arylamine N-acetyltransferase gene nomenclature

, 2008
Changes in consensus arylamine N-acetyltransferase (NAT) gene nomenclature determined at the 2007 International NAT Workshop include: (1) Alleles in all species except mouse and rat are all uppercase.
Boukouvala, Sotiria, Hein, David W., Grant, Denis M., Minchin, Rodney F., Sim, Edith, Boukouvala, Sotiriab   +5 more
core   +1 more source

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes. [PDF]

Sci Rep, 2020
Salazar-González RA, Doll MA, Hein DW.
europepmc   +1 more source

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer

Genetics and Molecular Biology, 2012
The arylamine N-acetyltransferase 2 (NAT2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. Point mutations in the NAT2 gene result in the variant alleles M1 (NAT2 *5A), M2 (NAT2*6A), M3 (NAT2*7) and M4 ...
Amjad Mahasneh, Amal Jubaili, Ahmed El Bateiha, Mohammad Al-Ghazo, Ismail Matalka, Mousa Malkawi   +5 more
doaj  

Pharmacogenomic heterogeneity of N-acetyltransferase 2: a comprehensive analysis of real world data in Indian tuberculosis patients and from literature and database review

Annals of Medicine
Background Isoniazid is primarily metabolized by the arylamine N-acetyltransferase 2 (NAT2) enzyme. Single nucleotide polymorphisms (SNPs) in the NAT2 gene could classify an individual into three distinct phenotypes: rapid, intermediate and slow ...
Levin Thomas, Chaithra, Yashi Batra, Mitali Mathur, Shrivathsa Kulavalli, Chidananda Sanju SV, Naveen Dutt, Pankaj Bhardwaj, Muralidhar Varma, Kavitha Saravu, Mithu Banerjee, Mahadev Rao   +11 more
doaj   +1 more source

Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.

, 1990
N-Acetylation by hepatic arylamine N-acetyltransferase (NAT, EC 2.3.1.5) is a major route in the metabolism and detoxification of numerous drugs and foreign chemicals.
Heim M, Meyer UA, Blum M, Grant DM, McBride W   +4 more
core   +1 more source

Mapping the genes for arylamine N-acetyltransferases

, 2000
Arylamine N-acetyltransferases are xenobiotic metabolising enzymes, involved in metabolic pathways leading to either detoxification or bio-activation of drugs and carcinogens. In humans, polymorphisms of the two functional NAT genes (NAT1 and NAT2} have been implicated to cancer susceptibility.
openaire   +2 more sources

Investigating the mechanisms by which low NAT1 expression in tumor cells contributes to chemo-resistance in colorectal cancer

Clinical Epigenetics
Background In the therapeutic landscape of colorectal cancer (CRC), chemo-resistance poses a significant and prevalent obstacle that complicates treatment efficacy and patient outcomes.
Zheng Yuan, Kai Fang, Xinsheng Miao, Yan Zhang, Menghui Gu, Wei Xu, Hao Li, Dawei Zhu, Jiahui Zhou, Jian Sun, Xinhua Gu   +10 more
doaj   +1 more source

Assessment of arylamine N-acetyltransferase (NAT1) activity in mononuclear leukocytes of cystic fibrosis patients

The clearance of sulphamethoxazole (SMX), a compound metabolised primarily by the N-acetyltransferase NAT1, is increased in cystic fibrosis (CF) patients.

core   +1 more source

CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. [PDF]

Sci Rep, 2020
Carlisle SM, Trainor PJ, Hong KU, Doll MA, Hein DW.   +4 more
europepmc   +1 more source