Results 101 to 110 of about 2,402 (195)

Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines. [PDF]

Toxicol Sci, 2022
Hong KU, Salazar-González RA, Walls KM, Hein DW.   +3 more
europepmc   +1 more source

Arylamine N-acetyltransferase 2 genotypes in a Mexican population

Genetics and Molecular Research, 2012
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican population.
L, Taja-Chayeb, J A, Agúndez, C, Miguez-Muñoz, A, Chavez-Blanco, A, Dueñas-Gonzalez   +4 more
openaire   +2 more sources

Subcellular Protein Labeling by a Spatially Restricted Arylamine N‑Acetyltransferase [PDF]

, 2018
Mapping proteins at a specific subcellular location is essential to gaining detailed insight on local protein dynamics. We have developed an enzymatic strategy to label proteins on a subcellular level using arylamine N-acetyltransferase (NAT).
Fleur Kleinpenning (4863481), Judith M. Schaart (4865659), Tim Berkenbosch (5395706), Kimberly M. Bonger (1856443), Selma Eising (4859815), Veronica Garzero (5395709)   +5 more
core   +1 more source

Deletion of the benzoxazinoid detoxification gene NAT1 in Fusarium graminearum reduces deoxynivalenol in spring wheat.

PLoS ONE, 2019
Benzoxazinoid (Bx) metabolites produced by wheat and other members of the Poaceae have activity against Fusarium sp. that cause cereal diseases including Fusarium head blight (FHB) on wheat and barley. Certain Bx metabolites can be detoxified by Fusarium
Thomas Baldwin, Suzette Baldwin, Kathy Klos, Phil Bregitzer, Juliet Marshall   +4 more
doaj   +1 more source

Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1. [PDF]

Arch Toxicol, 2022
Leggett CS, Doll MA, Salazar-González RA, Habil MR, Trent JO, Hein DW.   +5 more
europepmc   +1 more source

Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium Smegmatis [PDF]

, 2011
Mycobacterium tuberculosis, the most successful bacterial pathogen, causes tuberculosis, a disease that still causes more than 2 million deaths per year. Arylamine N-acetyltransferase is an enzyme that is conserved in most Mycobacterium spp. The nat gene
Nicholas H. Keep, Sanjib Bhakta, Sim, E., Keep, Nicholas H., Edith Sim, Bhakta, Sanjib, Daviter, Tina, Nora Cronin, Cronin, Nora, Evangelopoulos, Dimitrios, Dimitrios Evangelopoulos, Tina Daviter   +11 more
core   +1 more source

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris [PDF]

, 2007
In this study, we show that extracts and a purified compound of Warburgia salutaris exhibit anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium bovis BCG Pasteur.
Russell, AJ, Madikane, VE, Bhakta, S, Sim, E, Russell, Angela J., Madikane, Vukani Eliya, Campbell, William E., Smith, Peter, Davies, SG, Claridge, TD, Campbell, WE, Smith, P, Elisha, BG, Claridge, TDW, Elisha, B. Gay, Bhakta, Sanjib, Sim, Edith, Claridge, Timothy D. W., Davies, Stephen G., Davies, Stephen, Claridge, Timothy   +20 more
core   +1 more source

Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review. [PDF]

Expert Opin Drug Metab Toxicol, 2021
Hein DW, Millner LM.
europepmc   +1 more source

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase [PDF]

, 2003
Arylamine N-acetyltransferase (NAT) acetylates the front-line anti-tuberculosis drug isoniazid (INH) and has been identified in Mycobacterium tuberculosis.
Noble M, Kawamura, A, Sim, E, Sandy, J, Upton, A, Noble, Martin, Noble, M, Upton, Anna, Sandy J, Kawamura A, Sim, Edith, Kawamura, Akane, Sandy, James, Sim E, Upton A   +14 more
core   +1 more source

Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis. [PDF]

Mol Carcinog, 2022
Doll MA, Ray AR, Salazar-González RA, Shah PP, Vega AA, Sears SM, Krueger AM, Hong KU, Beverly LJ, Hein DW.   +9 more
europepmc   +1 more source