Results 81 to 90 of about 13,476,144 (183)

Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis [PDF]

, 2003
Tuberculosis is the world's largest cause of death from an infectious agent. Treatment is by an extended period of combination chemotherapy. Drug resistance is an increasing problem in tuberculosis therapy, particularly to the frontline anti-tubercular ...
Prof. E. Sim, Brooke, Edward W., Sim, E. (Edith)   +2 more
core   +2 more sources

Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3]

, 2012
Arylamine N-acetyltransferases (NATs) are xenobiotic metabolizing enzymes (XMEs) that catalyze the acetylation of arylamines. All functional NATs described to date possess a strictly conserved Cys-His-Asp catalytic triad.
Kubiak, Xavier, Pluvinage, Benjamin, Weber, Patrick, Rodrigues-Lima, Fernando, Haouz, Ahmed, Kubiak, Xavier Jean Philippe, Li de la Sierra-Gallay, Inès, Dupret, Jean-Marie   +7 more
core   +1 more source

Structure of Mesorhizobium loti arylamine N-acetyltransferase 1

The arylamine N-acetyltransferase (NAT) enzymes have been found in a broad range of both eukaryotic and prokaryotic organisms. The NAT enzymes catalyse the transfer of an acetyl group from acetyl Co-enzyme A onto the terminal nitrogen of a range of ...
Dairou J, Noble MEM, Sandy J, Rodrigues-Lima F, Holton SJ, Dupret JM, Sim E   +6 more
core   +5 more sources

Status Asetilator Gen NAT2 pada Pasien Tuberkulosis dan Tuberkulosis dengan Diabetes Melitus di Kupang, Nusa Tenggara Timur

Majalah Kedokteran Bandung, 2017
Indonesia is the second highest country with TB patients in the world. Diabetes mellitus (DM) is a comorbid of TB. Arylamine N-acetyltransferase 2 (NAT2), encoded by the NAT2 gene, is an enzyme that metabolizes isoniazid (INH).
Alvinsyah Adhityo Pramono, Simeon Penggoam, Edhyana Sahiratmadja, Novi Vicahyani Utami, Tri Hanggono Achmad, Ramdan Panigoro   +5 more
doaj   +1 more source

NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant

BMC Medical Genetics, 2004
Background Alzheimer's disease is multifactorial, having environmental, toxicological and genetic risk factors. Impaired folate and homocysteine metabolism has been hypothesised to increase risk. In addition to its xenobiotic-metabolising capacity, human
Budge Marc, Jonovska Vesna, Bell Peter, Johnson Nichola, Sim Edith   +4 more
doaj   +1 more source

Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.

Journal of Biological Chemistry, 1984
Amine N-acetylation in the pineal gland is of special importance because it is the first step in the synthesis of melatonin from serotonin. In the present study the N-acetylation of arylamines and arylalkylamines by homogenates of rat and sheep pineal glands was investigated.
P, Voisin, M A, Namboodiri, D C, Klein
openaire   +2 more sources

Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study. [PDF]

In Vivo, 2023
Hernandez-Gonzalez O, Del Carmen Milan-Segovia R, Zavala-Reyes D, Alvarado-Zamarripa DM, Ortiz-Zamudio JJ, Correa-Gonzalez LC, Vargas-Morales JM, Uresti-Rivera EE, Portales-Perez DP.   +8 more
europepmc   +1 more source

Arylamine N-acetyltransferase 2 genotypes in a Mexican population

Genetics and Molecular Research, 2012
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican population.
L, Taja-Chayeb, J A, Agúndez, C, Miguez-Muñoz, A, Chavez-Blanco, A, Dueñas-Gonzalez   +4 more
openaire   +2 more sources

Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines. [PDF]

Toxicol Sci, 2022
Hong KU, Salazar-González RA, Walls KM, Hein DW.   +3 more
europepmc   +1 more source

Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1. [PDF]

Arch Toxicol, 2022
Leggett CS, Doll MA, Salazar-González RA, Habil MR, Trent JO, Hein DW.   +5 more
europepmc   +1 more source