Frontiers in Physiology, 2015 The evolution of N-acetyltransfeases (NATs) seems complex. Vertebrate arylalkylamine N-acetyltransferase (aaNAT) has been extensively studied since it Leads to the synthesis of melatonin, a multifunctional neurohormone prevalent in photoreceptor cells ...
Susumu eHiragaki +3 more
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Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes [PDF]
, 1991 The expression of arylamine N-acetyltransferase (NAT) in leukocytes was investigated using p-aminobenzoic acid (PABA) and sulfamethazine (SMZ), substrates which are preferentially acetylated by the monomorphic NAT1 and polymorphic NAT2 enzymes ...
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Changes in consensus arylamine N-acetyltransferase gene nomenclature [PDF]
, 2008 Changes in consensus arylamine N-acetyltransferase (NAT) gene nomenclature determined at the 2007 International NAT Workshop include: (1) Alleles in all species except mouse and rat are all uppercase.
Boukouvala, Sotiria +5 more
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Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes [PDF]
The purpose of this study was to determine the molecular basis in the dog for an unusual and absolute deficiency in the activity of cytosolic N-acetyltransferase (NAT), an enzyme important for the metabolism of arylamine and hydrazine compounds.
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Arylamine N-acetyltransferase gene polymorphisms: markers for atopic asthma, serum IgE and blood eosinophil counts [PDF]
, 2006 Introduction: Polymorphisms in N-acetyltransferase 2 (NAT2), present on chromosome 8p22, are responsible for the N-acetylation variants, which segregate human populations into rapid, intermediate and slow acetylators and influence the susceptibility ...
Ghosh, Balaram +3 more
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Thiolsubtilisin acts as an acetyltransferase in organic solvents [PDF]
, 2002 The catalytic mechanism of arylamine N-acetyltransferase has been proposed to involve Cys-His-Asp as its catalytic triad. Thiolsubtilisin, a chemically modified enzyme that has a catalytic triad of Cys-His-Asp at the active site, mimics the catalysis of ...
Dar-Fu Tai +3 more
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Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis. [PDF]
Breast Cancer Res Treat, 2022 McAleese CE, Butcher NJ, Minchin RF.
europepmc +2 more sources
Estimation of N-acetyltransferase 2 haplotypes [PDF]
N-Acetyltransferase 2 (NAT2) genotyping may result in a considerable percentage in several ambiguous allele combinations. PHASE 2.1 is a statistical program which is designed to estimate the probability of different allele combinations.
Golka, Klaus +5 more
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Phenotype of the Most Common “Slow Acetylator ” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent [PDF]
, 2011 Human arylamine N-acetyltransferase 1 (NAT1) is a phase II cyto-solic enzyme responsible for the activation or deactivation of many arylamine compounds including pharmaceuticals and environmen-tal carcinogens.
J. Christopher States +4 more
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Insight into the structure of Mesorhizobium loti arylamine N-acetyltransferase 2 (MLNAT2): A biochemical and computational study [PDF]
, 2006 The arylamine N-acetyltransferases (NAT; EC 2.3.1.5) are xenobiotic-metabolizing enzymes (XME) that catalyze the transfer of an acetyl group from acetylCoA (Ac-CoA) to arylamine, hydrazines and their N-hydroxylated metabolites.
Chaffotte, Alain F. +6 more
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