NAT2 gene polymorphism in bladder cancer: a study from North India
International Brazilian Journal of Urology, 2004 PURPOSE: This study was conducted to examine: 1) whether the NAT2 genotypes are risk factors for bladder cancer, 2) to study possible association of tobacco usage with NAT2 genotype of these patients.
Rama D. Mittal +2 more
doaj +1 more source
Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2
Toxicology Reports, 2020 Recent reports suggest that arylamine N-acetyltransferases (NAT1 and/or NAT2) serve important roles in regulation of energy utility and insulin sensitivity. We investigated the interaction between diet (control vs. high-fat diet) and acetylator phenotype
Kyung U. Hong +10 more
doaj +1 more source
Small Molecule Colorimetric Probes for Specific Detection of Human Arylamine N-Acetyltransferase 1, a Potential Breast Cancer Biomarker [PDF]
, 2010 The identification, synthesis, and evaluation of a series of naphthoquinone derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 are described.
Fletcher, Ai M. +18 more
core +1 more source
Frontiers in Pharmacology, 2022 N-acetyltransferase 1 (NAT1) is a xenobiotic metabolizing enzyme that uses acetyl coenzyme A (AcCoA) as a cofactor for N-acetylation of many carcinogens including aromatic amines and alkylanilines. NAT1 is characterized by single nucleotide polymorphisms
Mariam R. Habil +2 more
doaj +1 more source
Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3] [PDF]
, 2012 Arylamine N-acetyltransferases (NATs) are xenobiotic metabolizing enzymes (XMEs) that catalyze the acetylation of arylamines. All functional NATs described to date possess a strictly conserved Cys-His-Asp catalytic triad.
Kubiak, Xavier +7 more
core +1 more source
Neonatal Ontogeny of Murine Arylamine N-Acetyltransferases: Implications for Arylamine Genotoxicity [PDF]
Toxicological Sciences, 2003 Age-related changes in the expression of xenobiotic biotransformation enzymes can result in differences in the rates of chemical activation and detoxification, affecting responses to the therapeutic and/or toxic effects of chemicals. Despite recognition that children and adults may exhibit differences in susceptibility to chemicals, information about ...
Charlene A, McQueen, Binh, Chau
openaire +2 more sources
NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review
PLoS ONE, 2023 Arylamine N-acetyltransferase 2 has been related to drug side effects and cancer susceptibility; its protein structure and acetylation capacity results from the polymorphism’s arrays on the NAT2 gene.
Jorge E. Gutiérrez-Virgen +6 more
doaj +2 more sources
Journal of Infection in Developing Countries, 2012 Introduction: Arylamine N-acetyltransferase-2 (NAT-2) is a key human enzyme in drug detoxification and elimination. Mutations in NAT-2 affect the activity of anti-tuberculosis drugs and result in three different phenotypes: rapid (RA), intermediate (IA)
Julián Gabriel Chamorro +5 more
doaj +1 more source
International Journal of Infectious Diseases, 2022 Objectives: This study investigated the steady-state pharmacokinetic profiles of 3-month weekly rifapentine plus isoniazid (3HP) in children with latent tuberculosisinfection (LTBI).
Weeraya Phaisal +6 more
doaj +1 more source
5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. [PDF]
PLoS ONE, 2013 Folate catabolism involves cleavage of the C(9)-N(10) bond to form p-aminobenzoylgluamate (PABG) and pterin. PABG is then acetylated by human arylamine N-acetyltransferase 1 (NAT1) before excretion in the urine.
Katey L Witham +5 more
doaj +1 more source