Results 31 to 40 of about 2,402 (195)

Effect of a hyaluronic acid‐based mesotherapeutic injectable on the gene expression of CLOCK and Klotho proteins, and environmentally induced oxidative stress in human skin cells

Journal of Cosmetic Dermatology, Volume 22, Issue 1, Page 156-172, January 2023., 2023
Abstract Objective Normal circadian rhythms are essential to the repair mechanisms of oxidative stress implicated in skin aging. Given reports that hyaluronic acid (HA) homeostasis exhibits a different profile in chronological skin aging, as compared to environmental or extrinsic aging, an improved understanding of the way HA interacts with its ...
Aleksei Prokopov, Anna Drobintseva, Igor Kvetnoy, Zarema Gazitaeva, Anna Sidorina   +4 more
wiley   +1 more source

Air pollution induces Staphylococcus aureus USA300 respiratory tract colonization mediated by specific bacterial genetic responses involving the global virulence gene regulators Agr and Sae

Environmental Microbiology, Volume 24, Issue 9, Page 4449-4465, September 2022., 2022
Summary Exposure to particulate matter (PM), a major component of air pollution, is associated with exacerbation of chronic respiratory disease, and infectious diseases such as community‐acquired pneumonia. Although PM can cause adverse health effects through direct damage to host cells, our previous study showed that PM can also impact bacterial ...
Jo Purves, Shane J. K. Hussey, Louise Corscadden, Lillie Purser, Andie Hall, Raju Misra, Liza Selley, Paul S. Monks, Julian M. Ketley, Peter W. Andrew, Julie A. Morrissey   +10 more
wiley   +1 more source

NAT2 and CYP2E1 polymorphisms and antituberculosis drug‐induced hepatotoxicity in Peruvian patients

Molecular Genetics &Genomic Medicine, Volume 10, Issue 8, August 2022., 2022
According to our results, the combination of the NAT2 polymorphism associated with the intermediate phenotype and the CYP2E1 C1/C1 genotype associated with the slow phenotype does not affect the therapeutic response and is suspected to be a protective factor against INH‐induced hepatotoxicity in Peruvian tuberculosis patients.
Luis Jaramillo‐Valverde, Kelly S. Levano, David D. Tarazona, Silvia Capristano, Roberto Zegarra‐Chapoñan, Cesar Sanchez, Velia M. Yufra‐Picardo, Eduardo Tarazona‐Santos, Cesar Ugarte‐Gil, Heinner Guio   +9 more
wiley   +1 more source

RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition. [PDF]

PLoS ONE, 2011
Arylamine N-acetyltransferase-1 (NAT1) is an enzyme that catalyzes the biotransformation of arylamine and hydrazine substrates. It also has a role in the catabolism of the folate metabolite p-aminobenzoyl glutamate.
Jacky M Tiang, Neville J Butcher, Carleen Cullinane, Patrick O Humbert, Rodney F Minchin   +4 more
doaj   +1 more source

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Clinical Pharmacology &Therapeutics, Volume 111, Issue 5, Page 1142-1154, May 2022., 2022
Mathematical models, such as physiologically‐based pharmacokinetic models, are used to predict, for example, drug disposition and toxicity. However, populations differ in the abundance of proteins involved in these processes. To improve the building and refinement of such models, they must take into account these interindividual variabilities.
Christine Wegler, Jacek R. Wiśniewski, Ida Robertsen, Hege Christensen, Jens Kristoffer Hertel, Jøran Hjelmesæth, Rasmus Jansson‐Löfmark, Anders Åsberg, Tommy B. Andersson, Per Artursson   +9 more
wiley   +1 more source

Colorectal cancer risk susceptibility loci in a Swedish population

Molecular Carcinogenesis, Volume 61, Issue 3, Page 288-300, March 2022., 2022
Abstract To search for colorectal cancer (CRC) risk loci, Swedish samples were used for a genome‐wide haplotype analysis. A logistic regression model was employed in 2663 CRC cases and 1642 controls in the discovery analysis. Three analyses were done, on all, familial‐, and nonfamilial CRC samples and only results with odds ratio (OR) > 1 were analyzed.
Wen Liu, Hovsep Mahdessian, Hafdis Helgadottir, Xingwu Zhou, Jessada Thutkawkorapin, Xiang Jiao, The Swedish Low‐risk Colorectal Cancer Study Group, Alicja Wolk, Annika Lindblom   +8 more
wiley   +1 more source

Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey. [PDF]

PLoS ONE, 2011
Arylamine N-acetyltransferase 2 (NAT2) is involved in human physiological responses to a variety of xenobiotic compounds, including common therapeutic drugs and exogenous chemicals present in the diet and the environment.
Audrey Sabbagh, Pierre Darlu, Brigitte Crouau-Roy, Estella S Poloni   +3 more
doaj   +1 more source

Anisi Stellati Fructus, a Significant Traditional Chinese Medicine (TCM) Herb and Its Bioactivity against Gastric Cancer

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Anisi stellati fructus (ASF) is the fruit of Illicium verum Hook F. (Chinese star anise), which is native to many countries, and is a significant Chinese medicinal herb. Gastric cancer (GC) is one of the major fatal types of cancers with multiple stages and a poor prognosis.
Maryam Khan, Saba Shamim, Qing Li
wiley   +1 more source

Structure and Mechanism of Arylamine N-Acetyltransferases

Current Topics in Medicinal Chemistry, 2006
Arylamine N-acetyltransferases (NATs) are a family of phase II drug-metabolising enzymes which are important in the biotransformation of various aromatic and heterocyclic amines and hydroxylamines, arylhydrazines and arylhydrazides. NATs are present in a wide range of eukaryotes and prokaryotes.
Westwood, I, Kawamura, A, Fullam, E, Russell, A, Davies, S, Sim, E   +5 more
openaire   +3 more sources

Human Arylamine N-Acetyltransferase Type 1 [PDF]

, 2018
Human arylamine N-acetyltransferase 1 (NAT1) is one of the two functional NATs in humans that acetylate primary arylamine and hydrazine xenobiotics. There is a growing body of evidence that suggests NAT1 may have an important physiological role in the ...
Rodney F. Minchin, Wang, Lili, Li, Pengcheng, Minchin, Rodney F., Neville J. Butcher, Pengcheng Li, Butcher, Neville J., Lili Wang   +7 more
core   +1 more source