A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity [PDF]
Acta Pharmaceutica Sinica B, 2018 Arylamine N-acetyltransferase (NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation.
Eneida Turiján-Espinoza +6 more
doaj +4 more sources
Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population [PDF]
Annals of Human Biology, 2017 Background: The arylamine N-acetyltransferase 2 (NAT2) is a key enzyme in the biotransformation of xenobiotics. NAT2 gene polymorphisms have been associated with the risk of isoniazid hepatotoxicity and these polymorphisms change among different ...
Malika Khelil
exaly +3 more sources
Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism [PDF]
BMC Cancer, 2017 Background Recent investigations suggest role(s) of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer. Rat NAT2 is orthologous to human NAT1 and the gene products are functional homologs. We conducted in vivo studies using F344.WKY-Nat2 rapid/
Marcus W. Stepp +5 more
doaj +4 more sources
Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes [PDF]
Acta Pharmaceutica Sinica B, 2017 Cryopreserved human hepatocytes were used to investigate the role of arylamine N-acetyltransferase 2 (NAT2; EC 2.3.1.5) polymorphism on the N-acetylation of isoniazid (INH).
Mark A. Doll +3 more
doaj +4 more sources
From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. [PDF]
PLoS ONE, 2014 Acetyl Coenzyme A-dependent N-, O- and N,O-acetylation of aromatic amines and hydrazines by arylamine N-acetyltransferases is well characterised. Here, we describe experiments demonstrating that human arylamine N-acetyltransferase Type 1 and its murine ...
Nicola Laurieri +7 more
doaj +3 more sources
Exploration of Piperidinols as Potential Antitubercular Agents [PDF]
Molecules, 2014 Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N ...
Areej Abuhammad +6 more
doaj +3 more sources
NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD +3 more
openaire +4 more sources
Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. [PDF]
PLoS ONE, 2012 Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection.
Areej Abuhammad +13 more
doaj +4 more sources
Carcinogenic potential of arylamine N-acetyltransferase in Asian populations [PDF]
Journal of Cancer Research and Practice, 2018 Arylamine N-acetyltransferase (NAT) is a phase II metabolizing enzyme, which belongs to the transferase family; specifically those acyltransferases which transfer various groups except aminoacyl. NATs are found in both prokaryotes and eukaryotes.
Saba Kabir, Abdul Rehman
doaj +2 more sources
3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine N-acetyltransferase, in Mycobacteria [PDF]
Antibiotics, 2020 In this study, the inhibitory potential of 3-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives was evaluated against a panel of bacteria, as well as mammalian cell lines to determine their therapeutic index.
Neha Agre +6 more
doaj +2 more sources