Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status [PDF]
Frontiers in Pharmacology, 2022 Arylamine N-acetyltransferase 1 (NAT1) is a drug metabolizing enzyme that influences cancer cell proliferation and survival, especially in breast cancer.
Raúl Salazar-Gonzalez +2 more
exaly +4 more sources
Human Arylamine N-Acetyltransferase 1 (NAT1) Knockout in MDA-MB-231 Breast Cancer Cell Lines Leads to Transcription of NAT2 [PDF]
Frontiers in Pharmacology, 2022 Many cancers, including breast cancer, have shown differential expression of human arylamine N-acetyltransferase 1 (NAT1). The exact effect this differential expression has on disease risk and progression remains unclear.
Patrick Trainor +2 more
exaly +4 more sources
Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
Annals of Human Biology, 2017 Background: The arylamine N-acetyltransferase 2 (NAT2) is a key enzyme in the biotransformation of xenobiotics. NAT2 gene polymorphisms have been associated with the risk of isoniazid hepatotoxicity and these polymorphisms change among different ...
Malika Khelil
exaly +3 more sources
A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity [PDF]
Acta Pharmaceutica Sinica B, 2018 Arylamine N-acetyltransferase (NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation.
Eneida Turiján-Espinoza +6 more
doaj +3 more sources
Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism [PDF]
BMC Cancer, 2017 Background Recent investigations suggest role(s) of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer. Rat NAT2 is orthologous to human NAT1 and the gene products are functional homologs. We conducted in vivo studies using F344.WKY-Nat2 rapid/
Marcus W. Stepp +5 more
doaj +3 more sources
560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment [PDF]
Frontiers in Pharmacology, 2022 Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). Genetic
Mark A. Doll, David W. Hein
doaj +2 more sources
From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. [PDF]
PLoS ONE, 2014 Acetyl Coenzyme A-dependent N-, O- and N,O-acetylation of aromatic amines and hydrazines by arylamine N-acetyltransferases is well characterised. Here, we describe experiments demonstrating that human arylamine N-acetyltransferase Type 1 and its murine ...
Nicola Laurieri +7 more
doaj +3 more sources
Exploration of Piperidinols as Potential Antitubercular Agents [PDF]
Molecules, 2014 Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N ...
Areej Abuhammad +6 more
doaj +2 more sources
Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population [PDF]
International Journal of Occupational Medicine and Environmental Health, 2023 Objectives Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC.
Monika Gogolewska +2 more
doaj +2 more sources
NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD +3 more
openaire +4 more sources