Results 1 to 10 of about 7,698 (108)

Analysis of ligand recognition by choline O-acetyltransferase reveals thiol-reactive assay interference and weak ligand affinity in solution. [PDF]

J Biol Chem
Choline O-acetyltransferase (ChAT) catalyzes the biosynthesis of acetylcholine and is a cysteine-rich enzyme that has been investigated using a range of biochemical, biophysical and structural approaches. Existing ChAT ligands rely on electrophilic or unstable scaffolds that limit their suitability for biological systems.
Forsgren N, Jonsson F, Carlsson M, Sander RA, Larsson A, Lindén P, Linusson A, Engdahl CS, Wiktelius D, Ekström F.   +9 more
europepmc   +3 more sources

Walnut Prevents Cognitive Impairment by Regulating the Synaptic and Mitochondrial Dysfunction via JNK Signaling and Apoptosis Pathway in High-Fat Diet-Induced C57BL/6 Mice

Molecules, 2022
This study was conducted to evaluate the protective effect of Juglans regia (walnut, Gimcheon 1ho cultivar, GC) on high-fat diet (HFD)-induced cognitive dysfunction in C57BL/6 mice.
Jong Hyun Moon, Jong Min Kim, Uk Lee, Jin Yong Kang, Min Ji Kim, Hyo Lim Lee, Hye Rin Jeong, Min Ji Go, Hyun-Jin Kim, Hye Won Park, Chul-Woo Kim, Sung Jin Park, Ho Jin Heo   +12 more
doaj   +1 more source

Ocimum sanctum Linn. stimulate the expression of choline acetyltransferase on the human cerebral microvascular endothelial cells [PDF]

Veterinary World, 2016
Aim: This research was conducted to identify the expression of choline acetyltransferase (ChAT) in human cerebral microvascular endothelial cells (HCMECs) and to clarify the capability of Ocimum sanctum Linn.
Dwi Liliek Kusindarta, Hevi Wihadmadyatami, Aris Haryanto   +2 more
doaj   +1 more source

Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns

Cellular & Molecular Biology Letters, 2021
Background The synaptic vesicle glycoprotein 2 (SV2) family is essential to the synaptic machinery involved in neurotransmission and vesicle recycling. The isoforms SV2A, SV2B and SV2C are implicated in neurological diseases such as epilepsy, Alzheimer’s
Emilia Lekholm, Mikaela M. Ceder, Erica C. Forsberg, Helgi B. Schiöth, Robert Fredriksson   +4 more
doaj   +1 more source

Exploring the neurogenic differentiation of human dental pulp stem cells.

PLoS ONE, 2022
Human dental pulp stem cells (hDPSCs) have increasingly gained interest as a potential therapy for nerve regeneration in medicine and dentistry, however their neurogenic potential remains a matter of debate.
Arwa A Al-Maswary, Molly O'Reilly, Andrew P Holmes, A Damien Walmsley, Paul R Cooper, Ben A Scheven   +5 more
doaj   +1 more source

Integrating precision medicine in the study and clinical treatment of a severely mentally ill person [PDF]

PeerJ, 2013
Background. In recent years, there has been an explosion in the number of technical and medical diagnostic platforms being developed. This has greatly improved our ability to more accurately, and more comprehensively, explore and characterize human ...
Jason A. O’Rawe, Han Fang, Shawn Rynearson, Reid Robison, Edward S. Kiruluta, Gerald Higgins, Karen Eilbeck, Martin G. Reese, Gholson J. Lyon   +8 more
doaj   +2 more sources

Molecular weight determinations of soluble and membrane-bound fractions of choline O-acetyltransferase in rat brain [PDF]

The Journal of Neuroscience, 1985
Three fractions of choline O-acetyltransferase (ChAT) (EC 2.3.1.6) were solubilized from a nerve ending fraction of rat forebrain using three sequential washes of an increasingly chaotrophic nature (100 mM sodium phosphate, pH 7.4; 500 mM NaCl; 2% Triton DN-65) as previously described (Benishin, C.G., and P.T. Carroll (1983) J. Neurochem. 41: 1030–1039)
M, Badamchian, P T, Carroll
openaire   +2 more sources

Diabetes-Induced Central Cholinergic Neuronal Loss and Cognitive Deficit Are Attenuated by Tacrine and a Chinese Herbal Prescription, Kangen-Karyu: Elucidation in Type 2 Diabetes db/db Mice

Journal of Pharmacological Sciences, 2011
.: We investigated the effect of kangen-karyu (KK), a Chinese herbal prescription, on cognitive deficits and central cholinergic systems of type 2 diabetic db/db mice. Seven-week-old db/db (Y-db/db) mice received daily administration of test drugs during
Qi Zhao, Kinzo Matsumoto, Koichi Tsuneyama, Ken Tanaka, Feng Li, Naotoshi Shibahara, Takeshi Miyata, Takako Yokozawa   +7 more
doaj   +1 more source

The Cholinergic and Adrenergic Autocrine Signaling Pathway Mediates Immunomodulation in Oyster Crassostrea gigas

Frontiers in Immunology, 2018
It is becoming increasingly clear that neurotransmitters impose direct influence on regulation of the immune process. Recently, a simple but sophisticated neuroendocrine–immune (NEI) system was identified in oyster, which modulated neural immune response
Zhaoqun Liu, Zhaoqun Liu, Zhaoqun Liu, Lingling Wang, Lingling Wang, Zhao Lv, Zhao Lv, Zhi Zhou, Weilin Wang, Meijia Li, Meijia Li, Qilin Yi, Limei Qiu, Linsheng Song, Linsheng Song   +14 more
doaj   +1 more source

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

Frontiers in Neuroanatomy, 2019
Relaxin-3 is a highly conserved neuropeptide abundantly expressed in neurons of the nucleus incertus (NI), which project to nodes of the septohippocampal system (SHS) including the medial septum/diagonal band of Broca (MS/DB) and dorsal hippocampus, as ...
Mouna Haidar, Mouna Haidar, Kimberly Tin, Kimberly Tin, Cary Zhang, Mohsen Nategh, João Covita, João Covita, Alexander D. Wykes, Alexander D. Wykes, Jake Rogers, Jake Rogers, Andrew L. Gundlach, Andrew L. Gundlach, Andrew L. Gundlach   +14 more
doaj   +1 more source