Results 1 to 10 of about 379,425 (268)

Glasdegib Dimaleate: Synthesis, Characterization and Comparison of Its Properties with Monomaleate Analogue

Pharmaceutics, 2022
Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is formulated and marketed in monomaleate salt form. In our investigation, we were able to prepare a glasdegib dimaleate form, which could, in theory, exist in double ...
Boris Peklar, Franc Perdih, Damjan Makuc, Janez Plavec, Jérôme Cluzeau, Zoran Kitanovski, Zdenko Časar   +6 more
doaj   +1 more source

Image-based dissolution analysis for tracking the surface stability of amorphous powders

ADMET and DMPK, 2020
Poor solubility of crystalline drugs can be overcome by amorphization – the production of high-energy disordered solid with improved solubility.
Jernej Štukelj, Mikael Agopov, Jouko Yliruusi, Clare J. Strachan, Sami Svanbäck   +4 more
doaj   +1 more source

Solids, colloids, and the hydrolysis of tetravalent uranium in chloride media

Frontiers in Nuclear Engineering, 2023
Understanding of the properties of dissolution and precipitation of Uranium under reducing geochemical conditions is important in radioactive waste management and assessments of natural uranium deposits. The mechanism of forming UO2+y from U(VI) and U(IV)
B. Grambow, B. Grambow, R. Müller, D. Schild, X. Gaona   +4 more
doaj   +1 more source

A New Method for Studying the Kinetics of the Release of Poorly Soluble API from Solid Oral Dosage Forms on the Example of Quertin®

Журнал органічної та фармацевтичної хімії, 2023
In this paper, it is proposed to consider a new method developed for studying the kinetics of release of substances that are poorly soluble in aqueous media on the example of quercetin. The study object was the drug containing plant bioactive components –
Nataliia V. Khanina, Victoriya A. Georgiyants, Vadim A. Khanin, Igor A. Zupanetz   +3 more
doaj   +1 more source

Preparation and Characterisation of Zinc Diethyldithiocarbamate–Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment

Pharmaceutics, 2023
Zinc diethyldithiocarbamate (Zn (DDC)2), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism.
Ayşe Kaya, Basel Arafat, Havovi Chichger, Ibrahim Tolaymat, Barbara Pierscionek, Mouhamad Khoder, Mohammad Najlah   +6 more
doaj   +1 more source

Synthesis, Characterization, and Stability Assessment for the Benzoate, Hydrochloride, Malonate, and Nicotinate Salts of Bedaquiline

Pharmaceuticals, 2023
Bedaquiline has been approved as a combination therapy to treat multi-drug-resistant tuberculosis in adults ≥ 18 years old. The citrate, fumarate, phosphate, and tartrate salts have obtained patents, but the structures for these moieties have not been ...
Mercy A. Okezue, Stephen R. Byrn
doaj   +1 more source

Cyclodextrine Based Nanogels and Phase Solubility Studies of Flurbiprofen as a Chemopreventive Agent

Proceedings, 2017
: Flurbiprofen (FB) is one of the nonsteroidal anti-inflammatory drugs (NSAIDs) which has low water solubility (1). In recent studies it is shown that NSAIDs tend to demonstrate chemopreventive activity and chemoprotective agents frequently show low ...
Ayşe Nur Oktay, Sibel İlbasmiş Tamer, Nevin Çelebi   +2 more
doaj   +1 more source

Solubility of baclofen in 1-hexyl-4-methylpyridinium bromide + water binary mixtures [PDF]

شیمی کاربردی روز, 2017
In this paper, solubility of baclofen was studied by gravimetric method. The solubility of baclofen was measured in (water + 1-hexyl-4-methylpyridinium bromide) binary mixtures from 293.1 K to 313.1 K under atmosphere pressure.
Abbas Mehrdad, Sahar Ehsani-Tabar, Sara Taeb   +2 more
doaj   +1 more source

The Ethaline Effect on Feruloyl Esterase Activity

Proceedings, 2019
In recent years, extractions using natural deep eutectic. [...]
Ioana-Cristina Marinaș, Bogdan Trică, Carmen-Valentina Nicolae, Florin Oancea, Diana Constantinescu-Aruxandei   +4 more
doaj   +1 more source

Development and Characterization of a Novel Spray-Dried Powder for Inhalation of Cinacalcet HCl Nanoparticles [PDF]

Pharmaceutical Sciences
Background: Administering Cinacalcet HCl (CINA) can be challenging because of its low oral bioavailability (20 to 25%) due mainly to its high first-pass metabolism and poor aqueous solubility.
Katayoon Mireskandari, Mostafa Rostamnezhad, Majid Darabi, Mohammadreza Rouini, Alireza Vatanara   +4 more
doaj   +1 more source