Results 21 to 30 of about 591,880 (308)

Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [PDF]

, 2010
Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).
Estime, Nicolas, Biscans, Béatrice, Teychené, Sébastien, Autret, Jean Marie   +3 more
core   +1 more source

Development and Characterization of a Novel Spray-Dried Powder for Inhalation of Cinacalcet HCl Nanoparticles [PDF]

Pharmaceutical Sciences
Background: Administering Cinacalcet HCl (CINA) can be challenging because of its low oral bioavailability (20 to 25%) due mainly to its high first-pass metabolism and poor aqueous solubility.
Katayoon Mireskandari, Mostafa Rostamnezhad, Majid Darabi, Mohammadreza Rouini, Alireza Vatanara   +4 more
doaj   +1 more source

Water solubility in aluminosilicate melts of haplogranite composition at 2 kbar [PDF]

, 1992
The compositional dependence of H2O solubility was investigated at 2 kbar and 800°C in haplogranite melts (system SiO2---1bNaAlSi3O8---1bKAlSi3O8 or Qz---1bAb---1bOr).
Taylor, Richard P., Holtz, François, Behrens, Harald, Dingwell, Donald B.   +3 more
core   +1 more source

The boehmite ‘solubility gap’ [PDF]

, 2010
Boehmite, rather than gibbsite, precipitation has been proposed in the literature as a potential energy-saving modification of the Bayer process for the production of alumina. Previous experimental studies have reported that true equilibrium solubilities
Erich Königsberger, Ilievski, D., Königsberger, L.C., Königsberger, E., LanChi Königsberger, Dean Ilievski   +5 more
core   +1 more source

Solubility Products and Solubility Concepts

, 2017
The chapter refers to a general concept of solubility product Ksp of sparingly soluble hydroxides and different salts and calculation of solubility of some hydroxides, oxides, and different salts in aqueous media. A (criticized) conventional approach, based on stoichiometry of a reaction notation and the solubility product of a precipitate, is compared
Anna Maria Michałowska-Kaczmarczyk, Aneta Spórna-Kucab, Tadeusz Michałowski   +2 more
openaire   +3 more sources

Theoretically Guided Analytical Method Development and Validation for the Estimation of Rifampicin in a Mixture of Isoniazid and Pyrazinamide by UV Spectrophotometer

Frontiers in Chemistry, 2017
A simple, rapid, economic, accurate, and precise method for the estimation of rifampicin in a mixture of isoniazid and pyrazinamide by UV spectrophotometeric technique (guided by the theoretical investigation of physicochemical properties) was developed ...
Mohammad F. Khan, Shamima A. Rita, Md. Shahidulla Kayser, Md. Shariful Islam, Sharmeen Asad, Ridwan Bin Rashid, Md. Abdul Bari, Muhammed M. Rahman, D. A. Anwar Al Aman, Nurul I. Setu, Rebecca Banoo, Mohammad A. Rashid   +11 more
doaj   +1 more source

THE SOLUBILITY OF GYPSUM. [PDF]

Journal of the American Chemical Society, 1902
n ...
Hulett, George A., Allen, Lucius E.
openaire   +2 more sources

Decision trees to characterise the roles of permeability and solubility on the prediction of oral absorption. [PDF]

, 2015
Oral absorption depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal absorption ...
Newby, Danielle, Ghafourian, Taravat, Freitas, Alex. A., Danielle Newby (1695076), Alex A Freitas (16236734), Taravat Ghafourian (4466557), Freitas, Alex A.   +6 more
core   +1 more source

An evaluation of thermodynamic models for the prediction of drug and drug-like molecule solubility in organic solvents [PDF]

, 2011
Prediction of solubility of active pharmaceutical ingredients (API) in different solvents is one of the main issue for crystallization process design. Experimental determination is not always possible because of the small amount of product available in ...
Béatrice Biscans, Biscans, Béatrice, Sébastien Teychené, Baptiste Bouillot, Bouillot, Baptiste, Teychené, Sébastien   +5 more
core   +1 more source

Thymoquinone-Loaded Soluplus^®-Solutol^® HS15 Mixed Micelles: Preparation, In Vitro Characterization, and Effect on the SH-SY5Y Cell Migration

Molecules, 2020
Thymoquinone (TQ) is the main active ingredient of Nigella sativa essential oil, with remarkable anti-neoplastic activities with anti-invasive and anti-migratory abilities on a variety of cancer cell lines.
Maria Camilla Bergonzi, Marzia Vasarri, Giulia Marroncini, Emanuela Barletta, Donatella Degl’Innocenti   +4 more
doaj   +1 more source