Results 1 to 10 of about 162,626 (165)

Surface Solid Dispersion and Solid Dispersion of Meloxicam: Comparison and Product Development [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible ...
Mayank Chaturvedi, Manish Kumar, Kamla Pathak, Shailendra Bhatt, Vipin Saini   +4 more
doaj   +4 more sources

Green Approach to Enhance Dissolution of Gliclazide: Thermoresponsive Solid Dispersion Based on Poloxamer 188/Propylene Glycol/Labrasol Ternary System [PDF]

Pharmaceutics
Background/Objectives: Gliclazide’s limited water solubility restricts its absorption across the gastrointestinal tract and compromises its therapeutic performance.
Abdelrahman Y. Sherif, Mohamed A. Ibrahim   +1 more
doaj   +2 more sources

Enhancement of dissolution of Telmisartan through use of solid dispersion technique surface solid dispersion

Journal of Pharmacy and Bioallied Sciences, 2012
The present study was aimed to increase the solubility of the poorly water soluble drug Telmisartan by using Surface solid dispersion (SSD) made of polymers like Poloxamer 407, PEG 6000 by Solvent evaporation method.
Bhumika Patel, R H Parikh, Deepali Swarnkar   +2 more
doaj   +3 more sources

Fundamental aspects of solid dispersion technology for poorly soluble drugs

Acta Pharmaceutica Sinica B, 2014
The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug–polymer two-component system, the drug–polymer interaction is the determining factor in its design and ...
Yanbin Huang, Wei-Guo Dai
doaj   +3 more sources

Solubility Enhancement of Carvedilol by Solid Dispersion Technique Using Sodium Alginate, Guar Gum, Xanthan Gum, and Locust Bean Gum as Polymers

Indonesian Journal of Chemistry, 2023
Carvedilol (CVD) is a non-selective β-blocker. CVD is included in BCS class II. It has low water solubility. In this research, solid dispersion was used to increase the solubility and dissolution profile of CVD.
Iyan Sopyan, Nurdiani Adiningsih, Sandra Megantara, Siska Sari Marvita   +3 more
doaj   +1 more source

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Preparation and Characterization of Carvedilol Solid Dispersion by Kneading Method

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Solid dispersion using hydrophilic carrier is one of the approaches that has a potential to increase solubility, dissolution rate and consequently the oral bioavailability of poorly-water soluble drugs.
Ali Q. Hatem, Wedad K. Ali
doaj   +1 more source

Formulation and evaluation of fast dissolving tablets of haloperidol solid dispersion

Saudi Pharmaceutical Journal, 2022
Purpose: The aim of this study was to design fast dissolving tablets (FDT) of the anti –psychiatric drug haloperidol in solid dispersion forms as a way to enhance its dissolution profile and anti-psychiatric effect.
Aya M. Eisa, Nagia A. El-Megrab, Hanan M. El-Nahas   +2 more
doaj   +1 more source

Current Trends on Solid Dispersions: Past, Present, and Future

Advances in Pharmacological and Pharmaceutical Sciences, 2022
Solid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bioavailability of a range of weakly water-soluble drugs.
Ruba Malkawi, Walla I. Malkawi, Yahia Al-Mahmoud, Jawad Tawalbeh   +3 more
doaj   +1 more source

Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets

Asian Journal of Pharmaceutical Sciences, 2019
The objective of this study is to evaluate the feasibility of obtaining extended release of tacrolimus by a novel combination of lipid-based solid dispersion and matrix-type extended release tablet techniques.
Hui Xu, Li Liu, Xuehui Li, Junyuan Ma, Rui Liu, Shaoning Wang   +5 more
doaj   +1 more source