Results 11 to 20 of about 162,725 (264)

Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement

ADMET and DMPK, 2023
Introduction: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability.
Leena Patil, Umakant Verma, Rahul Rajput, Pritam Patil, Anniruddha Chaterjee, Jitendra B. Naik   +5 more
doaj   +1 more source

DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN

Journal of Fundamental and Applied Sciences, 2015
Sustained release tablets containing solid dispersions granules of a poorly water soluble drug were prepared to investigate the controlled release of the drug.
K. H. Janardhana, R. Deveswaran, S. Bharath, B. V. Basavaraj, V. Madhavan   +4 more
doaj   +1 more source

The characterization and dissolution performances of spray dried solid dispersion of ketoprofen in hydrophilic carriers

Asian Journal of Pharmaceutical Sciences, 2015
Solid dispersion is one of the most promising strategies to improve oral bioavailability of poorly soluble API. However, there are inconsistent dissolution performances of solid dispersion reported which entails further investigation.
Siok-Yee Chan, Yin-Ying Chung, Xin-Zi Cheah, Eryn Yen-Ling Tan, Joan Quah   +4 more
doaj   +1 more source

Most promising solid dispersion technique of oral dispersible tablet

Beni-Suef University Journal of Basic and Applied Sciences, 2020
Background The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet.
Vikrant K. Nikam, Shubham K. Shete, Jyoti P. Khapare   +2 more
doaj   +1 more source

Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs

Pharmaceutical Sciences and Research, 2023
Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses.
Maria Elvina Tresia Butar-Butar, Nasrul Wathoni, Hestiary Ratih, Yoga Windhu Wardhana   +3 more
doaj   +1 more source

A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique

Bulletin of Faculty of Pharmacy Cairo University, 2012
The solid dispersion method was originally used to improve the dissolution properties and the bioavailability of poorly water soluble drugs by dispersing them into water soluble carriers.
Tapan Kumar Giri, Kulesh Kumar, Amit Alexander, Ajazuddin, Hemant Badwaik, Dulal Krishna Tripathi   +5 more
doaj   +1 more source

Sustained-Release Solid Dispersion of High-Melting-Point and Insoluble Resveratrol Prepared through Hot Melt Extrusion to Improve Its Solubility and Bioavailability

Molecules, 2021
This study aimed to prepare a sustained-release solid dispersion of poorly water-soluble resveratrol (RES) with high melting point in a single hot melt extrusion step.
Wenjing Zhu, Wenling Fan, Xiaotong Zhang, Meiqi Gao   +3 more
doaj   +1 more source

The Amorphous Solid Dispersion of Chrysin in Plasdone^® S630 Demonstrates Improved Oral Bioavailability and Antihyperlipidemic Performance in Rats

Pharmaceutics, 2023
Chrysin is a flavonoid with various biological activities. However, its low water solubility and strong metabolism render its oral bioavailability rather poor.
Chenhui Wang, Xiaowei Liu, Ruihan Zhao, Meiqing Yang, Wenqian Liu, Qiuyang Dai, Xiaofeng Bao, Yong Chen, Jun Ma   +8 more
doaj   +1 more source

DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN [PDF]

Journal of Fundamental and Applied Sciences, 2013
Sustained release tablets containing solid dispersions granules of a poorly water soluble drug were prepared to investigate the controlled release of the drug.
K. H. Janardhana, R. Deveswaran, S. Bharath, B.V. Basavaraj, V. Madhavan   +4 more
doaj  

ENHANCEMENT OF DISSOLUTION AND ANALGESIC ACTIVITY OF CELECOXIB USING TERNARY SYSTEM [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2009
The purpose of the present study is to investigate the drugloaded solid dispersion system consisting of a drug, a carrier and asurfactant. Solid dispersions of a water insoluble drug celecoxib(CX) with PVP 40000, namely binary solid dispersion systems ...
Mohamed Amin
doaj   +1 more source