Results 1 to 10 of about 130,252 (119)

Surface Solid Dispersion and Solid Dispersion of Meloxicam: Comparison and Product Development [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible ...
Mayank Chaturvedi, Manish Kumar, Kamla Pathak, Shailendra Bhatt, Vipin Saini   +4 more
doaj   +2 more sources

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement

ADMET and DMPK, 2023
Introduction: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability.
Leena Patil, Umakant Verma, Rahul Rajput, Pritam Patil, Anniruddha Chaterjee, Jitendra B. Naik   +5 more
doaj   +1 more source

Solubility and Dissolution Enhancement of Ebastine by Surface Solid Dispersion Technique

Iraqi Journal of Pharmaceutical Sciences, 2021
Ebastine (EBS) is a non-sedating antihistamine with a long duration of action. This drug has predominantly hydrophobic property causing a low solubility and low bioavailability.
Lina S. Hussein, Eman B. H. Al-Khedairy
doaj   +1 more source

Sustained-Release Solid Dispersion of High-Melting-Point and Insoluble Resveratrol Prepared through Hot Melt Extrusion to Improve Its Solubility and Bioavailability

Molecules, 2021
This study aimed to prepare a sustained-release solid dispersion of poorly water-soluble resveratrol (RES) with high melting point in a single hot melt extrusion step.
Wenjing Zhu, Wenling Fan, Xiaotong Zhang, Meiqi Gao   +3 more
doaj   +1 more source

Wave Dispersion Behavior in Quasi-Solid State Concrete Hydration

Sensors, 2023
This paper aims to investigate wave dispersion behavior in the quasi-solid state of concrete to better understand microstructure hydration interactions. The quasi-solid state refers to the consistency of the mixture between the initial liquid–solid stage
Yin Chao Wu, Sanggoo Kang, Yeongseok Jeong, Dafnik Saril Kumar David, Suyun Ham   +4 more
doaj   +1 more source

CFD simulation of gas-liquid floating particles mixing in an agitated vessel [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2017
Gas dispersion and floating particles suspension in an agitated vessel were studied numerically by using computational fluid dynamics (CFD). The Eulerian multi-fluid model along with standard k-ε turbulence model was used in the simulation.
Li Liangchao, Xu Bin
doaj   +1 more source

Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin

Science and Technology Indonesia, 2023
Research to increase the solubility of active pharmaceutical ingredients is usually conducted by reducing the particle size. This research is one side that used the solid dispersion systems to increase solubility, especially on macrolide antibiotics for ...
Mardiyanto, Budi Untari, Ady Mara, Diko Fahri Ferdiansyah   +3 more
doaj   +1 more source

Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification

Pharmaceutics, 2023
Particulate amorphous solid dispersions (ASDs) have been recognised for their potential to enhance the performance of various solid dose forms, especially oral bioavailability and macromolecule stability.
Danni Suhaidi, Yao-Da Dong, Paul Wynne, Karen P. Hapgood, David A. V. Morton   +4 more
doaj   +1 more source

Enhancement of dissolution of Telmisartan through use of solid dispersion technique surface solid dispersion

Journal of Pharmacy and Bioallied Sciences, 2012
The present study was aimed to increase the solubility of the poorly water soluble drug Telmisartan by using Surface solid dispersion (SSD) made of polymers like Poloxamer 407, PEG 6000 by Solvent evaporation method.
Bhumika Patel, R H Parikh, Deepali Swarnkar   +2 more
doaj   +1 more source