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Surface Solid Dispersion and Solid Dispersion of Meloxicam: Comparison and Product Development [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible ...
Mayank Chaturvedi, Manish Kumar, Kamla Pathak, Shailendra Bhatt, Vipin Saini   +4 more
doaj   +5 more sources

Solubility and Dissolution Enhancement of Ebastine by Surface Solid Dispersion Technique

Iraqi Journal of Pharmaceutical Sciences, 2021
Ebastine (EBS) is a non-sedating antihistamine with a long duration of action. This drug has predominantly hydrophobic property causing a low solubility and low bioavailability.
Lina S. Hussein, Eman B. H. Al-Khedairy
doaj   +3 more sources

Enhancement of dissolution of Telmisartan through use of solid dispersion technique surface solid dispersion

Journal of Pharmacy and Bioallied Sciences, 2012
The present study was aimed to increase the solubility of the poorly water soluble drug Telmisartan by using Surface solid dispersion (SSD) made of polymers like Poloxamer 407, PEG 6000 by Solvent evaporation method.
Bhumika Patel, R H Parikh, Deepali Swarnkar   +2 more
doaj   +3 more sources

Solubility and Dissolution Enhancement of Lornoxicam by Surface Solid Dispersion

Iraqi Journal of Pharmaceutical Sciences
Lornoxicam (LOX) is (NSAID); it is a crystalline powder that ranges in color from orange to yellow and is practically insoluble in water. The aim of this study is to increase the solubility and dissolution of LOX using the surface solid dispersions SSD ...
Riyam Sadiq Jafer , Hanan Jalal Kassab
doaj   +2 more sources

Development, evaluation and characterization of surface solid dispersion for solubility and dispersion enhancement of irbesartan

Journal of Pharmacy Research, 2013
Abstract Aim The present study is to prepare and assess Irbesartan loaded surface solid dispersions (SSD) for enhancing the solubility and bioavailability of poor soluble drug. Method Irbesartan loaded SSD were prepared by co-evaporation method by using five different super disintegrants like crospovidone, croscarmellose sodium, potato starch ...
Ramakrishna Dadigala, Madhusudhan Alle, G Veerabhadram   +2 more
exaly   +2 more sources

Development and characterization of surface solid dispersion of curcumin for solubility enhancement

Journal of Applied Pharmaceutical Research, 2014
Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose
Mahendra Vikram Singh, Divya Juyal, Vikram Singh, Geeta Rawat, Akhilesh Tiwari   +4 more
doaj   +2 more sources

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement

ADMET and DMPK, 2023
Introduction: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability.
Leena Patil, Umakant Verma, Rahul Rajput, Pritam Patil, Anniruddha Chaterjee, Jitendra B. Naik   +5 more
doaj   +1 more source

Sustained-Release Solid Dispersion of High-Melting-Point and Insoluble Resveratrol Prepared through Hot Melt Extrusion to Improve Its Solubility and Bioavailability

Molecules, 2021
This study aimed to prepare a sustained-release solid dispersion of poorly water-soluble resveratrol (RES) with high melting point in a single hot melt extrusion step.
Wenjing Zhu, Wenling Fan, Xiaotong Zhang, Meiqi Gao   +3 more
doaj   +1 more source

Wave Dispersion Behavior in Quasi-Solid State Concrete Hydration

Sensors, 2023
This paper aims to investigate wave dispersion behavior in the quasi-solid state of concrete to better understand microstructure hydration interactions. The quasi-solid state refers to the consistency of the mixture between the initial liquid–solid stage
Yin Chao Wu, Sanggoo Kang, Yeongseok Jeong, Dafnik Saril Kumar David, Suyun Ham   +4 more
doaj   +1 more source