Results 61 to 70 of about 35,074 (278)

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes

JCI Insight, 2022
While current thinking posits that insulin signaling to glucose transporter 4 (GLUT4) exocytic translocation and glucose uptake in skeletal muscle and adipocytes is controlled by phosphorylation-based signaling, many proteins in this pathway are ...
Vitor F. Martins, Samuel A. LaBarge, Alexandra Stanley, Kristoffer Svensson, Chao-Wei Hung, Omer Keinan, Theodore P. Ciaraldi, Dion Banoian, Ji E. Park, Christina Ha, Byron Hetrick, Gretchen A. Meyer, Andrew Philp, Larry L. David, Robert R. Henry, Joseph E. Aslan, Alan R. Saltiel, Carrie. E. McCurdy, Simon Schenk   +18 more
doaj   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

EXPRESSION OF GENES OF IODOTHYRONINE DEIODINASES TYPES 1, 2 AND 3, IODOTYROSINE DEIODINASE, THYROID HORMONE RECEPTOR ALPHA AND BETA AND ACETYLTRANSFERASES TYPES 1 AND 2 IN PATIENTS WITH EUTHYROID AND TOXIC GOITER IN THE IRKUTSK REGION

Байкальский медицинский журнал
Background. Thyroid gland pathology is the leading endocrine disease. According to modern requirements of a personalized approach to medicine, there is a need to study the expression of genes involved in immunoregulation and biosynthesis of thyroid ...
Elena A. Ilyicheva, Lyubov V. Rodionova, Liliya G. Samoilova, Tatiana A. Roy, Gleb A. Bersenev   +4 more
doaj   +1 more source

N-Alpha-Acetyltransferases and Regulation of CFTR Expression.

PLoS ONE, 2016
The majority of cystic fibrosis (CF)-causing mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to the misfolding, mistrafficking, and degradation of the mutant protein.
Ali J Vetter, Andrey L Karamyshev, Anna E Patrick, Henry Hudson, Philip J Thomas   +4 more
doaj   +1 more source

Acetylation of general transcription factors by histone acetyltransferases [PDF]

, 1997
The acetylation of histones increases the accessibility of nucleosomal DNA to transcription factors [1,2], relieving transcriptional repression [3] and correlating with the potential for transcriptional activity in vivo[4–7].
Ogryzko, Vasily V, Imhof, Axel, Wolffe, Alan P, Ge, Hui, Yang, Xiang-Jiao, Nakatani, Yoshihiro   +5 more
core   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype

Life Science Alliance
This study shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway causing a progeria-like phenotype.
Tzu-Lin Cheng, Feixuan Wu, Md Ezazul Haque, Abigail R Thiel, Danqing Wang, Jeffrey J Helgager, Lingjun Li, Luigi Puglielli   +7 more
doaj   +1 more source

O-acetylated Gangliosides as Targets for Cancer Immunotherapy

Cells, 2020
O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli, Philippe Delannoy, Sophie Groux-Degroote   +2 more
doaj   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source