Results 61 to 70 of about 33,126 (285)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

N-Alpha-Acetyltransferases and Regulation of CFTR Expression.

PLoS ONE, 2016
The majority of cystic fibrosis (CF)-causing mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to the misfolding, mistrafficking, and degradation of the mutant protein.
Ali J Vetter, Andrey L Karamyshev, Anna E Patrick, Henry Hudson, Philip J Thomas   +4 more
doaj   +1 more source

Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype

Life Science Alliance
This study shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway causing a progeria-like phenotype.
Tzu-Lin Cheng, Feixuan Wu, Md Ezazul Haque, Abigail R Thiel, Danqing Wang, Jeffrey J Helgager, Lingjun Li, Luigi Puglielli   +7 more
doaj   +1 more source

Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism

Communications Biology, 2021
Rigby et al. use transgenic mice that are deficient in the endoplasmic reticulum acetyltransferases Atase1 or Atase2 to demonstrate the differential role of these enzymes in the regulation of reticulophagy and macroautophagy.
Michael J. Rigby, Alexis J. Lawton, Gulpreet Kaur, Varuna C. Banduseela, William E. Kamm, Aparna Lakkaraju, John M. Denu, Luigi Puglielli   +7 more
doaj   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages [PDF]

, 2012
Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection.
Russell, AJ, Edith Sim, Staunton, D, Angela J Russell, Staunton David, Russell Angela J., Areej Abuhammad (106459), Staunton, David, Westwood, IM, Stephen G Davies, Seden Peter T., Elizabeth Fullam (106463), Davies, Stephen G, Bhakta, Sanjib, Lowe, Edward D., Sim, Edith, David Staunton, Edward D. Lowe (106466), Akane Kawamura (50084), Seden, PT, Lowe, ED, Sim, E, Fullam Elizabeth, Fullam, Elizabeth, Garman, Elspeth F., Abuhammad Areej, Russell, Angela J, David L Wilson, Westwood Isaac M., Elspeth F Garman, Abuhammad, Areej, Davies, Stephen G., Davies, Stephen, Garman Elspeth F., Garman, Elspeth, Seden, Peter T, Kawamura, A, Sanjib Bhakta (106475), Elspeth F. Garman (106483), Fullam, E, Bhakta, S, Westwood, Isaac M, Garner, Alun Christopher, Russell, Angela J., Lowe Edward D., Garner, AC, Isaac M Westwood, Kawamura Akane, Bhakta Sanjib, Westwood, Isaac, Garner Alun Christopher, Akane Kawamura, Alun Christopher Garner (106477), Seden, Peter T., Alun Christopher Garner, Kawamura, Akane, Abuhammad, A, Elizabeth Fullam, Lowe, Edward D, Isaac M. Westwood (106473), David L. Wilson (74373), Angela J. Russell (106482), Wilson, DL, Davies, SG, Edward D Lowe, Wilson, David L., Peter T. Seden (106479), Wilson, David L, Sanjib Bhakta, Peter T Seden, Davies Stephen G., Garman, EF, Edith Sim (50087), Wilson David L., Stephen G. Davies (106481), Areej Abuhammad, David Staunton (106470), Garman, Elspeth F, Sim Edith   +78 more
core   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Nature Communications, 2021
Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product.
Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner   +22 more
doaj   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Illuminating the impact of N-terminal acetylation: from protein to physiology

Nature Communications
N-terminal acetylation is a highly abundant protein modification in eukaryotic cells. This modification is catalysed by N-terminal acetyltransferases acting co- or post-translationally. Here, we review the eukaryotic N-terminal acetylation machinery: the
Nina McTiernan, Ine Kjosås, Thomas Arnesen   +2 more
doaj   +1 more source