Results 81 to 90 of about 47,710 (299)

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Development of a High Throughput Screen for the Identification of Inhibitors of Peptidoglycan O-Acetyltransferases, New Potential Antibacterial Targets

Antibiotics, 2019
The O-acetylation of peptidoglycan occurs in many Gram-negative and most Gram-positive pathogens and this modification to the essential wall polymer controls the lytic activity of the autolysins, particularly the lytic transglycosylases, and inhibits ...
Ashley S. Brott, Carys S. Jones, Anthony J. Clarke   +2 more
doaj   +1 more source

Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. [PDF]

, 2018
Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the ...
McKinsey, Timothy A, Vondriska, Thomas M, Wang, Yibin   +2 more
core  

Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening [PDF]

, 2015
Background: The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei.
Bernard A. M. Fang, FengDi Li, GangDe Zhao, HaiQing Wu, Hui Wang, KeHui Liu, LanYi Lin, Qing Xie, Shisan Bao, WeiLiang Tang, XiaoGang Xiang   +10 more
core   +3 more sources

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases

Computational and Structural Biotechnology Journal, 2020
N-terminal acetyltransferases (NATs) belong to the superfamily of acetyltransferases. They are enzymes catalysing the transfer of an acetyl group from acetyl coenzyme A to the N-terminus of polypeptide chains.
Angèle Abboud, Pierre Bédoucha, Jan Byška, Thomas Arnesen, Nathalie Reuter   +4 more
doaj   +1 more source

Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms [PDF]

, 2016
Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs).
A Ametzazurra, A Ben-Bassat, A Hershko, A Marintchev, A Murthi, A Pimenta-Marques, A Shemorry, A Staes, A Yoshikawa, AF Rope, AI Saeed, AL Pang, AO Helbig, B Polevoda, B Polevoda, B Polevoda, B Polevoda, B Polevoda, B Zybailov, BC Williams, CS Hwang, D Lang, D Zattas, DC Scott, EC Park, EV Koonin, G Liszczak, G Liszczak, G Liszczak, G Talavera, G Zhang, GM Forte, H Aksnes, HS Yoon, HY Zhu, I Dikiy, I Hofmann, J Sanchez, JD Jones, JL Brown, JM Singer, JP Casey, JR Mullen, K Hole, KK Starheim, KK Starheim, KK Starheim, LG Guilgur, LM Myklebust, M Gautschi, MA Larkin, MD Katinka, ML Angus-Hill, N Arnaudo, OK Song, P Van Damme, P Van Damme, P Van Damme, P Van Damme, P Van Damme, P Van Damme, R Behnia, R Evjenth, R Shemesh, RD Finn, RD Silva, RP Moerschell, S Capella-Gutierrez, S Goetze, S Hoshiyasu, S Tanaka, SF Altschul, SR Setty, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Esmailpour, T van Welsem, TB Chou, TV Dinh, TV Kalvik, TY James, WV Bienvenut, WV Bienvenut, Y Wang, YY Chang   +88 more
core   +2 more sources

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Exploring the Complexity of Protein-Level Dosage Compensation that Fine-Tunes Stoichiometry of Multiprotein Complexes.

PLoS Genetics, 2020
Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated ...
Koji Ishikawa, Akari Ishihara, Hisao Moriya   +2 more
doaj   +1 more source

Acetylation Unleashes Protein Demons of Dementia [PDF]

, 2007
Aberrant posttranslational modifications of proteins can impair synaptic plasticity and may render neurons vulnerable to degeneration during aging. In this issue of Neuron, Min et al.
Atsuko Nagai, Mika Miyazono, Ryuhei Takahashi, Takehiko Ohashi, Tomonobu Jiku, Yohei Ozoe, Yuya Hata, 大橋 毅彦, 宮薗 美佳, 尾添 陽平, 永井 敦子, 畑 裕哉, 竺 友信, 高橋 隆平   +13 more
core   +3 more sources