The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis [PDF]
Frontiers in Oncology, 2015 Histone or non-histone protein acetylation plays important roles in all kinds of cellular events, including the normal and abnormal development of blood cells, through changing the epigenetic status of chromatin and regulating non-histone protein’s ...
Xiao-Jian Sun, Na Man, Stephen Nimer
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Garcinol and Anacardic Acid, Natural Inhibitors of Histone Acetyltransferases, Inhibit Rhabdomyosarcoma Growth and Proliferation [PDF]
Molecules, 2023 Rhabdomyosarcoma (RMS) is a malignant tumour of the soft tissues. There are two main histopathological types: alveolar and embryonal. RMS occurs mainly in childhood and is a result of the deregulation of growth and differentiation of muscle cell ...
Dorota Roginska +2 more
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HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis [PDF]
Frontiers in Plant Science, 2017 Arabidopsis has 12 histone acetyltransferases grouped in four families: the GNAT/HAG, the MYST/HAM, the p300/CBP/HAC and the TAFII250/HAF families. We previously showed that ham1 and ham2 mutants accumulated higher damaged DNA after UV-B exposure than WT
Sebastian Pablo Rius, Paula Casati
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Molecular characterization and modulated expression of histone acetyltransferases during cold response of the tick Dermacentor silvarum (Acari: Ixodidae) [PDF]
Parasites & Vectors, 2023 Background Histone acetylation is involved in the regulation of stress responses in multiple organisms. Dermacentor silvarum is an important vector tick species widely distributed in China, and low temperature is a crucial factor restricting the ...
Tingwei Pei +8 more
doaj +2 more sources
Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity [PDF]
Circulation, 2022 William Sessa +2 more
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Histone acetyltransferases in plant development and plasticity. [PDF]
Curr Genomics, 2014 In eukaryotes, transcriptional regulation is determined by dynamic and reversible chromatin modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, that are essential for the processes of DNA replication, DNA-repair, recombination and gene transcription.
Boycheva I, Vassileva V, Iantcheva A.
europepmc +4 more sources
Metformin Induces Apoptosis in Human Pancreatic Cancer (PC) Cells Accompanied by Changes in the Levels of Histone Acetyltransferases (Particularly, p300/CBP-Associated Factor (PCAF) Protein Levels) [PDF]
Pharmaceuticals, 2023 Józef Drzewoski +2 more
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Posttranslational regulation of the GCN5 and PCAF acetyltransferases
PLoS Genetics, 2022 General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate.
Onyekachi E. Ononye, Michael Downey
doaj +2 more sources
How Histone Acetyltransferases Shape Plant Photomorphogenesis and UV Response [PDF]
International Journal of Molecular SciencesIrina Boycheva +2 more
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Roles of histone acetylation sites in cardiac hypertrophy and heart failure
Frontiers in Cardiovascular Medicine, 2023 Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure.
Masafumi Funamoto +3 more
doaj +1 more source