The role of histone acetyltransferases in normal and malignant hematopoiesis [PDF]
Frontiers in Oncology, 2015 Histone or non-histone protein acetylation plays important roles in all kinds of cellular events, including the normal and abnormal development of blood cells, through changing the epigenetic status of chromatin and regulating non-histone protein’s ...
Xiao-Jian eSun +4 more
doaj +7 more sources
Histone Acetyltransferases and Stem Cell Identity [PDF]
Cancers, 2021 Simple Summary Gene regulation is the major mechanism that allows us to develop from a single cell to a fully formed adult body containing numerous organs and tissues, >200 cell types and a total of about 50 trillion cells. One of the ways our cells turn
Ruicen He, Arthur Dantas, K. Riabowol
semanticscholar +6 more sources
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
BioEssays, 2018 Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair.
A. Voss, T. Thomas
semanticscholar +6 more sources
Garcinol and Anacardic Acid, Natural Inhibitors of Histone Acetyltransferases, Inhibit Rhabdomyosarcoma Growth and Proliferation [PDF]
Molecules, 2023 Rhabdomyosarcoma (RMS) is a malignant tumour of the soft tissues. There are two main histopathological types: alveolar and embryonal. RMS occurs mainly in childhood and is a result of the deregulation of growth and differentiation of muscle cell ...
Patrycja Tomasiak +5 more
doaj +4 more sources
HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis [PDF]
Frontiers in Plant Science, 2017 Arabidopsis has 12 histone acetyltransferases grouped in four families: the GNAT/HAG, the MYST/HAM, the p300/CBP/HAC and the TAFII250/HAF families. We previously showed that ham1 and ham2 mutants accumulated higher damaged DNA after UV-B exposure than WT
Julieta P. Fina +4 more
doaj +7 more sources
Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease. [PDF]
Current Medicinal Chemistry, 2017 Histone acetyltransferases (HATs) are epigenetic drivers that catalyze the acetyl transfer from acetyl-CoA to lysines of both histone and non-histone substrates and thereby induce transcription either by chromatin remodeling or direct transcription ...
A. Richters, A. Koehler
semanticscholar +4 more sources
Histone acetyltransferases: challenges in targeting bi-substrate enzymes [PDF]
Clin Epigenetics, 2016 Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging
H. Wapenaar, F. Dekker
semanticscholar +5 more sources
Histone Acetyltransferases: Rising Ancient Counterparts to Protein Kinases [PDF]
Biopolymers, 2013 Protein kinases catalyze phosphorylation, a posttranslational modification widely utilized in cell signaling. Histone acetyltransferases (HATs) catalyze a counterpart posttranslational modification of acetylation which marks histones for epigenetic ...
H. Yuan, R. Marmorstein
semanticscholar +4 more sources
Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents [PDF]
Theranostics, 2022 The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their sequence homology and functional overlap and co-operation, are emerging as critical drivers of oncogenesis in the past several years.
Qingjuan Chen +5 more
semanticscholar +2 more sources
Molecular characterization and modulated expression of histone acetyltransferases during cold response of the tick Dermacentor silvarum (Acari: Ixodidae) [PDF]
Parasites & Vectors, 2023 Background Histone acetylation is involved in the regulation of stress responses in multiple organisms. Dermacentor silvarum is an important vector tick species widely distributed in China, and low temperature is a crucial factor restricting the ...
Tingwei Pei +8 more
doaj +2 more sources