Results 11 to 20 of about 24,866 (282)
Histone Acetyltransferases and Stem Cell Identity. [PDF]
Cancers (Basel), 2021 Acetylation of histones is a key epigenetic modification involved in transcriptional regulation. The addition of acetyl groups to histone tails generally reduces histone-DNA interactions in the nucleosome leading to increased accessibility for transcription factors and core transcriptional machinery to bind their target sequences.
He R, Dantas A, Riabowol K.
europepmc +5 more sources
Regulating histone acetyltransferases and deacetylases [PDF]
EMBO reports, 2003 Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with ...
Gaëlle, Legube, Didier, Trouche
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Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
BioEssays, 2018 Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general ...
Voss, AK, Thomas, T
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A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases
Cell ReportsSummary: Histone acetylation is a critical modification that regulates gene expression by modulating chromatin structure and function. Histone acetyltransferases are essential for maintaining acetylation homeostasis, and the disruption of this balance ...
Xuekun Fu +5 more
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The BRCA2 is a histone acetyltransferase [PDF]
Oncogene, 1998 Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
H, Siddique +3 more
openaire +2 more sources
Nature Communications, 2022 Here the authors show phosphorylation of heat shock factor 1 (HSF1) at S419 via the chromatin-bound kinase PLK1, promotes HSF1 recruitment of histone acetyltransferases and histone acetylation reader proteins TRIM33 and TRIM24, which actually also ...
Mitsuaki Fujimoto +8 more
doaj +1 more source
, 2020 p300 and CREB-binding protein (CBP) are ubiquitously expressed pleiotropic lysine acetyltransferases and play a key role as transcriptional co-activators that are essential for a multitude of cellular processes.
Zhifeng Chen (2340808) +13 more
core +7 more sources
Histone acetyltransferases: Rising ancient counterparts to protein kinases [PDF]
Biopolymers, 2013 Ronen Marmorstein
exaly +2 more sources
International Journal of Immunopathology and Pharmacology, 2021 Chronic inflammation in asthmatics is initiated/exacerbated by many environmental factors, such as bacterial lipopolysaccharide and allergens. Phospholipase A 2 and histone acetyltransferase/deacetylases are enzymes involved in inflammatory process ...
Ewa Pniewska-Dawidczyk +7 more
doaj +1 more source
Biological functions and therapeutic potential of acylation by histone acetyltransferases
Acta Materia Medica, 2023 Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression.
Nan Li +6 more
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