Results 11 to 20 of about 37,852 (313)

Dysregulation of the p300/CBP histone acetyltransferases in human cancer. [PDF]

Epigenomics
Xu L, Xuan H, Shi X.
europepmc   +3 more sources

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity. [PDF]

Circulation, 2022
Chakraborty R, Ostriker AC, Xie Y, Dave JM, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, Schulz VP, Gallagher PG, Sessa WC, Hwa J, Martin KA.   +14 more
europepmc   +2 more sources

A Review of the Effects of Curcumin on Histone Acetyltransferase Activity in the Prevention of Cardiac Hypertrophy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: Curcumin, a natural polyphenolic compound derived from the rhizome of turmeric, has a cardiovascular protective effects. Histone acetyltransferase (HAT) is a consequential enzyme in processes of cardiac hypertrophy (cardiomegaly)
E Habibi, H Esmaeeli
doaj   +1 more source

Posttranslational regulation of the GCN5 and PCAF acetyltransferases

PLoS Genetics, 2022
General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate.
Onyekachi E. Ononye, Michael Downey
doaj   +2 more sources

Roles of histone acetylation sites in cardiac hypertrophy and heart failure

Frontiers in Cardiovascular Medicine, 2023
Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure.
Masafumi Funamoto, Masaki Imanishi, Koichiro Tsuchiya, Yasumasa Ikeda   +3 more
doaj   +1 more source

Transcription shapes genome-wide histone acetylation patterns

Nature Communications, 2021
Histone acetylation is a ubiquitous hallmark of transcription. Here the authors provide evidence that the majority of histone acetylation is dependent on transcription, specifically due to the requirement of RNAPII for the recruitment and activity of ...
Benjamin J. E. Martin, Julie Brind’Amour, Anastasia Kuzmin, Kristoffer N. Jensen, Zhen Cheng Liu, Matthew Lorincz, LeAnn J. Howe   +6 more
doaj   +1 more source

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Nature Communications, 2022
Here the authors show phosphorylation of heat shock factor 1 (HSF1) at S419 via the chromatin-bound kinase PLK1, promotes HSF1 recruitment of histone acetyltransferases and histone acetylation reader proteins TRIM33 and TRIM24, which actually also ...
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai   +8 more
doaj   +1 more source

Expression of cPLAγ mRNA and protein differs the response of PBMC from severe and non-severe asthmatics to bacterial lipopolysaccharide and house dust mite allergen

International Journal of Immunopathology and Pharmacology, 2021
Chronic inflammation in asthmatics is initiated/exacerbated by many environmental factors, such as bacterial lipopolysaccharide and allergens. Phospholipase A 2 and histone acetyltransferase/deacetylases are enzymes involved in inflammatory process ...
Ewa Pniewska-Dawidczyk, Izabela Kupryś-Lipińska, Gabriela Turek, Dorota Kacprzak, Joanna Wieczfinska, Paulina Kleniewska, Piotr Kuna, Rafal Pawliczak   +7 more
doaj   +1 more source

Biological functions and therapeutic potential of acylation by histone acetyltransferases

Acta Materia Medica, 2023
Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression.
Nan Li, Clark Hamor, Yahang An, Licheng Zhu, Yusheng Gong, Yukimatsu Toh, Yusong R. Guo   +6 more
doaj   +1 more source

Different adaptation strategies of two citrus scion/rootstock combinations in response to drought stress [PDF]

, 2017
Scion/rootstock interaction is important for plant development and for breeding programs. In this context, polyploid rootstocks presented several advantages, mainly in relation to biotic and abiotic stresses.
Bonatto, Diego, Coelho Filho, Mauricio Antonio, Da Silva Gesteira, Abelmon, De Andrade Silva, Edson Mario, de Souza, Joadson Dutra, Micheli, Fabienne, Morillon, Raphaël   +6 more
core   +8 more sources