The transcriptional coactivators p300 and CBP are histone acetyltransferases. [PDF]
Cell, 1996 p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the
Vasily Ogryzko +4 more
semanticscholar +4 more sources
Regulating histone acetyltransferases and deacetylases [PDF]
The EMBO Reports, 2003 Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with ...
Gaëlle, Legube, Didier, Trouche
openaire +5 more sources
Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs). [PDF]
Bioorganic and Medicinal Chemistry, 2011 A novel class of KAT modulators (long chain alkylidenemalonates, LoCAMs) has been identified. Variations of the alkyl chain length can change the activity profile from inhibition of both KAT3A/KAT2B (as derivative 2a) to the peculiar profile of ...
Ciro Milite +10 more
semanticscholar +4 more sources
Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs) [PDF]
, 2014 Histone acetyltransferases (HATs) are interesting targets for the treatment of cancer and HIV infections but reports on selective inhibitors are very limited.
Silviya D. Furdas +8 more
semanticscholar +5 more sources
Histone Acetyltransferases in Plant Development and Plasticity [PDF]
Curr Genomics, 2014 In eukaryotes, transcriptional regulation is determined by dynamic and reversible chromatin modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, that are essential for the processes of DNA replication, DNA ...
Irina Boycheva +2 more
semanticscholar +2 more sources
A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases [PDF]
Cell ReportsSummary: Histone acetylation is a critical modification that regulates gene expression by modulating chromatin structure and function. Histone acetyltransferases are essential for maintaining acetylation homeostasis, and the disruption of this balance ...
Xuekun Fu +5 more
doaj +2 more sources
Dysregulation of Histone Acetyltransferases and Deacetylases in Cardiovascular Diseases [PDF]
Oxid Med Cell Longev, 2014 Cardiovascular disease (CVD) remains a leading cause of mortality worldwide despite advances in its prevention and management. A comprehensive understanding of factors which contribute to CVD is required in order to develop more effective treatment ...
Yonggang Wang +6 more
semanticscholar +2 more sources
SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases [PDF]
DNA Repair, 2015 The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response.
Gwendolyn Bennett, C. Peterson
semanticscholar +2 more sources
Expression analysis of histone acetyltransferases in rice under drought stress. [PDF]
Biochemical and Biophysical Research Communications - BBRC, 2014 Histone acetylation is one of the vital reversible modifications of chromatin structure that regulates gene expression in eukaryotes. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) maintain the homeostasis of histone acetylation ...
Hui Fang +4 more
semanticscholar +2 more sources
Inhibition of Histone Lysine Acetyltransferases by Coenzyme A Analogs [PDF]
MoleculesHistone lysine acetylation is a widespread posttranslational modification, essential for vital functions in eukaryotic organisms. Histone lysine acetyltransferases (KATs) employ acetyl-coenzyme A as a universal acetyl donor for acetylation of lysine ...
Faidra Voukia +3 more
doaj +2 more sources