Results 11 to 20 of about 140,246 (282)
Regulating histone acetyltransferases and deacetylases [PDF]
The EMBO Reports, 2003 Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with ...
Gaëlle, Legube, Didier, Trouche
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Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
BioEssays, 2018 Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general ...
Voss, AK, Thomas, T
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A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases
Cell ReportsSummary: Histone acetylation is a critical modification that regulates gene expression by modulating chromatin structure and function. Histone acetyltransferases are essential for maintaining acetylation homeostasis, and the disruption of this balance ...
Xuekun Fu +5 more
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Histone Acetyltransferases and Stem Cell Identity. [PDF]
Cancers (Basel), 2021 Acetylation of histones is a key epigenetic modification involved in transcriptional regulation. The addition of acetyl groups to histone tails generally reduces histone-DNA interactions in the nucleosome leading to increased accessibility for ...
He R, Dantas A, Riabowol K.
europepmc +2 more sources
Transcription shapes genome-wide histone acetylation patterns
Nature Communications, 2021 Histone acetylation is a ubiquitous hallmark of transcription. Here the authors provide evidence that the majority of histone acetylation is dependent on transcription, specifically due to the requirement of RNAPII for the recruitment and activity of ...
Benjamin J. E. Martin +6 more
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The BRCA2 is a histone acetyltransferase [PDF]
Oncogene, 1998 Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
H, Siddique +3 more
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Nature Communications, 2022 Here the authors show phosphorylation of heat shock factor 1 (HSF1) at S419 via the chromatin-bound kinase PLK1, promotes HSF1 recruitment of histone acetyltransferases and histone acetylation reader proteins TRIM33 and TRIM24, which actually also ...
Mitsuaki Fujimoto +8 more
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Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs) [PDF]
, 2014 Histone acetyltransferases (HATs) are interesting targets for the treatment of cancer and HIV infections but reports on selective inhibitors are very limited.
Robaa, Dina +3 more
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Inhibition of histone acetyltransferase by glycosaminoglycans [PDF]
Journal of Cellular Biochemistry, 2008 AbstractHistone acetyltransferases (HATs) are a class of enzymes that participate in modulating chromatin structure and gene expression. Altered HAT activity has been implicated in a number of diseases, yet little is known about the regulation of HATs.
Jo Ann, Buczek-Thomas +4 more
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International Journal of Immunopathology and Pharmacology, 2021 Chronic inflammation in asthmatics is initiated/exacerbated by many environmental factors, such as bacterial lipopolysaccharide and allergens. Phospholipase A 2 and histone acetyltransferase/deacetylases are enzymes involved in inflammatory process ...
Ewa Pniewska-Dawidczyk +7 more
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