Results 21 to 30 of about 24,866 (282)

Inhibition of histone acetyltransferase by glycosaminoglycans [PDF]

Journal of Cellular Biochemistry, 2008
AbstractHistone acetyltransferases (HATs) are a class of enzymes that participate in modulating chromatin structure and gene expression. Altered HAT activity has been implicated in a number of diseases, yet little is known about the regulation of HATs.
Jo Ann, Buczek-Thomas, Edward, Hsia, Celeste B, Rich, Judith A, Foster, Matthew A, Nugent   +4 more
openaire   +2 more sources

Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton, Becker, Peter, Ferreira, Roger   +2 more
core   +1 more source

Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases

, 2022
Histone lysine methyltransferases and acetyltransferases are two classes of epigenetic enzymes that play pivotal roles in human gene regulation. Although they both recognise and posttranslationally modify lysine residues in histone proteins, their ...
Boltje, Thomas J., Hintzen, Jordi C. J., Langens, Sabine G. H. A., White, Paul B., Maas, Marijn N., Merx, Jona, Mecinović, Jasmin; id_orcid   +6 more
core   +1 more source

Autoacetylation of the Histone Acetyltransferase Rtt109 [PDF]

Journal of Biological Chemistry, 2011
Rtt109 is a yeast histone acetyltransferase (HAT) that associates with histone chaperones Asf1 and Vps75 to acetylate H3K56, H3K9, and H3K27 and is important in DNA replication and maintaining genomic integrity. Recently, mass spectrometry and structural studies of Rtt109 have shown that active site residue Lys-290 is acetylated.
Brittany N, Albaugh, Kevin M, Arnold, Susan, Lee, John M, Denu   +3 more
openaire   +2 more sources

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer

, 2023
KAT6A, and its paralog KAT6B, are histone lysine acetyltransferases (HAT) that acetylate histone H3K23 and exert an oncogenic role in several tumor types including breast cancer where KAT6A is frequently amplified/overexpressed.
Khan, S, Chung, CY, Wang, Z, Zhang, Y, Tsaparikos, K, Brodsky, O, Johnson, E, Wang, H, Nady, N, Rickard, A, Greasley, S, Cao, J, Petrovic, J, Sharma, S, et al., Uryu, S   +15 more
core   +1 more source

The Sas3p and Gcn5p histone acetyltransferases are recruited to similar genes. [PDF]

, 2007
Background Specific histone modifications can perform several cellular functions, for example, as signals to recruit trans-acting factors and as modulators of chromatin structure.
Lorena E Rosaleny, Tordera Donderis, Vicente, García Martínez, José, Ana B Ruiz-García, Vicente Tordera, Pérez Ortín, José Enrique, Lorena E Rosaleny, Ruiz García, Ana Belén, José García-Martínez, Rosaleny Peralvo, Lorena Estefanía, José E Pérez-Ortín   +10 more
core   +1 more source

Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)

, 2014
Histone acetyltransferases (HATs) are interesting targets for the treatment of cancer and HIV infections but reports on selective inhibitors are very limited.
Robaa, Dina, Jung, Manfred, Hoffmann, Inga, Furdas, Silviya Dimitrova   +3 more
core   +2 more sources

Plant Responses to Abiotic Stress Regulated by Histone Deacetylases

Frontiers in Plant Science, 2017
In eukaryotic cells, histone acetylation and deacetylation play an important role in the regulation of gene expression. Histone acetylation levels are modulated by histone acetyltransferases and histone deacetylases (HDACs).
Ming Luo, Kai Cheng, Yingchao Xu, Songguang Yang, Songguang Yang, Keqiang Wu   +5 more
doaj   +1 more source