Results 21 to 30 of about 140,296 (249)

How Histone Acetyltransferases Shape Plant Photomorphogenesis and UV Response [PDF]

International Journal of Molecular Sciences
Irina Boycheva, Georgi Bonchev, Valya Vassileva   +2 more
exaly   +2 more sources

Transcription shapes genome-wide histone acetylation patterns

Nature Communications, 2021
Histone acetylation is a ubiquitous hallmark of transcription. Here the authors provide evidence that the majority of histone acetylation is dependent on transcription, specifically due to the requirement of RNAPII for the recruitment and activity of ...
Benjamin J. E. Martin, Julie Brind’Amour, Anastasia Kuzmin, Kristoffer N. Jensen, Zhen Cheng Liu, Matthew Lorincz, LeAnn J. Howe   +6 more
doaj   +1 more source

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Nature Communications, 2022
Here the authors show phosphorylation of heat shock factor 1 (HSF1) at S419 via the chromatin-bound kinase PLK1, promotes HSF1 recruitment of histone acetyltransferases and histone acetylation reader proteins TRIM33 and TRIM24, which actually also ...
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai   +8 more
doaj   +1 more source

Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs) [PDF]

, 2014
Histone acetyltransferases (HATs) are interesting targets for the treatment of cancer and HIV infections but reports on selective inhibitors are very limited.
Robaa, Dina, Jung, Manfred, Hoffmann, Inga, Furdas, Silviya Dimitrova   +3 more
core   +2 more sources

Expression of cPLAγ mRNA and protein differs the response of PBMC from severe and non-severe asthmatics to bacterial lipopolysaccharide and house dust mite allergen

International Journal of Immunopathology and Pharmacology, 2021
Chronic inflammation in asthmatics is initiated/exacerbated by many environmental factors, such as bacterial lipopolysaccharide and allergens. Phospholipase A 2 and histone acetyltransferase/deacetylases are enzymes involved in inflammatory process ...
Ewa Pniewska-Dawidczyk, Izabela Kupryś-Lipińska, Gabriela Turek, Dorota Kacprzak, Joanna Wieczfinska, Paulina Kleniewska, Piotr Kuna, Rafal Pawliczak   +7 more
doaj   +1 more source

Biological functions and therapeutic potential of acylation by histone acetyltransferases

Acta Materia Medica, 2023
Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression.
Nan Li, Clark Hamor, Yahang An, Licheng Zhu, Yusheng Gong, Yukimatsu Toh, Yusong R. Guo   +6 more
doaj   +1 more source

Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton, Becker, Peter, Ferreira, Roger   +2 more
core   +1 more source

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]

, 2018
Histone acetylation has been recognized as an important post-translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair.
Thomas, T, Voss, AK
core   +1 more source

Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases

, 2022
Histone lysine methyltransferases and acetyltransferases are two classes of epigenetic enzymes that play pivotal roles in human gene regulation. Although they both recognise and posttranslationally modify lysine residues in histone proteins, their ...
Boltje, Thomas J., Hintzen, Jordi C. J., Langens, Sabine G. H. A., White, Paul B., Maas, Marijn N., Merx, Jona, Mecinović, Jasmin; id_orcid   +6 more
core   +1 more source

Regulating histone acetyltransferases and deacetylases [PDF]

, 2003
Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated
Trouche, Didier, Gaëlle Legube, Didier Trouche, Legube, Gaëlle   +3 more
core   +1 more source