Results 31 to 40 of about 140,296 (249)

Characterisation of Sulfolobus solfataricus Ard1, a promiscuous N-acetyltransferase [PDF]

, 2008
Compaction of DNA into chromatin is an important feature of every living cell. This compaction phenomenon is brought about and maintained by a variety of DNA binding proteins, which have evolved to suit the specific needs of the different cell types ...
Mackay, Dale Tara
core   +2 more sources

Plant Responses to Abiotic Stress Regulated by Histone Deacetylases

Frontiers in Plant Science, 2017
In eukaryotic cells, histone acetylation and deacetylation play an important role in the regulation of gene expression. Histone acetylation levels are modulated by histone acetyltransferases and histone deacetylases (HDACs).
Ming Luo, Kai Cheng, Yingchao Xu, Songguang Yang, Songguang Yang, Keqiang Wu   +5 more
doaj   +1 more source

Histone Acetylation and Modifiers in Renal Fibrosis

Frontiers in Pharmacology, 2022
Histones are the most abundant proteins bound to DNA in eukaryotic cells and frequently subjected to post-modifications such as acetylation, methylation, phosphorylation and ubiquitination.
Fengchen Shen, Shougang Zhuang, Shougang Zhuang   +2 more
doaj   +1 more source

The Sas3p and Gcn5p histone acetyltransferases are recruited to similar genes. [PDF]

, 2007
Background Specific histone modifications can perform several cellular functions, for example, as signals to recruit trans-acting factors and as modulators of chromatin structure.
Lorena E Rosaleny, Tordera Donderis, Vicente, García Martínez, José, Ana B Ruiz-García, Vicente Tordera, Pérez Ortín, José Enrique, Lorena E Rosaleny, Ruiz García, Ana Belén, José García-Martínez, Rosaleny Peralvo, Lorena Estefanía, José E Pérez-Ortín   +10 more
core   +1 more source

ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation

Nature Communications, 2023
Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes acetyl-CoA production for histone acetylation remains unclear.
Qiutao Xu, Yaping Yue, Biao Liu, Zhengting Chen, Xuan Ma, Jing Wang, Yu Zhao, Dao-Xiu Zhou   +7 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

TACC3 mediates the association of MBD2 with histone acetyltransferases: a novel mechanism for reactivation of methylated promoters [PDF]

, 2006
We have recently reported that a novel MBD2 interactor (MBDin) has the capacity to reactivate transcription from MBD2-repressed methylated promoters even in the absence of demethylation events. Here we show that another unrelated protein, TACC3, displays
Angrisano, Tiziana
core   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

How do histone acetyltransferases select lysine residues in core histones? [PDF]

, 1998
Acetylation of specific lysines of core histone N-terminal tails correlates with chromatin assembly and specific regulation of gene expression. Core histones acetylated at particular lysines mediate effects on chromatin function; however, the manner in ...
Kimura, Akatsuki, Masami Horikoshi, Akatsuki Kimura, Horikoshi, Masami   +3 more
core   +1 more source

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer

, 2023
KAT6A, and its paralog KAT6B, are histone lysine acetyltransferases (HAT) that acetylate histone H3K23 and exert an oncogenic role in several tumor types including breast cancer where KAT6A is frequently amplified/overexpressed.
Khan, S, Chung, CY, Wang, Z, Zhang, Y, Tsaparikos, K, Brodsky, O, Johnson, E, Wang, H, Nady, N, Rickard, A, Greasley, S, Cao, J, Petrovic, J, Sharma, S, et al., Uryu, S   +15 more
core   +1 more source