Histone Acetylation and Modifiers in Renal Fibrosis
Frontiers in Pharmacology, 2022 Histones are the most abundant proteins bound to DNA in eukaryotic cells and frequently subjected to post-modifications such as acetylation, methylation, phosphorylation and ubiquitination.
Fengchen Shen +2 more
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ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation
Nature Communications, 2023 Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes acetyl-CoA production for histone acetylation remains unclear.
Qiutao Xu +7 more
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Temporal and spatial distribution of histone acetylation in mouse molar development [PDF]
PeerJHistone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Wen Du +4 more
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Nature Communications, 2021 Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product.
Manish Kumar +22 more
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Roles and regulation of histone acetylation in hepatocellular carcinoma
Frontiers in Genetics, 2022 Hepatocellular Carcinoma (HCC) is the most frequent malignant tumor of the liver, but its prognosis is poor. Histone acetylation is an important epigenetic regulatory mode that modulates chromatin structure and transcriptional status to control gene ...
Jin-kun Xia +8 more
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H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation [PDF]
, 2011 Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied.
Richard J. Festenstein +31 more
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Dissecting the roles of histone deacetylase 1 and 2 in the hematopoietic system [PDF]
, 2008 Reversible histone acetylation on lysine residues has been intensively studied as an epigenetic mark for gene activation in a variety of eukaryotes. Histone deacetylases (HDACs) act to repress gene expression by removing acetyl groups from histones and ...
Yamaguchi, Teppei
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Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model
Molecular Neurodegeneration, 2017 Background The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer’s disease (AD). In addition to histone acetyltransferases (HATs) and histone deacetylases (HDACs), inhibitor of acetyltransferases (INHAT) can also ...
Gao-Shang Chai +9 more
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Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications
Research, 2023 Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA)
Sha Li +7 more
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Histone acetyltransferases: challenges in targeting bi-substrate enzymes. [PDF]
Clin Epigenetics, 2016 Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging
Wapenaar H, Dekker FJ.
europepmc +2 more sources