Results 31 to 40 of about 241,476 (303)

The BRCA2 is a histone acetyltransferase [PDF]

Oncogene, 1998
Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
H, Siddique, J P, Zou, V N, Rao, E S, Reddy   +3 more
openaire   +2 more sources

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer [PDF]

, 2023
KAT6A, and its paralog KAT6B, are histone lysine acetyltransferases (HAT) that acetylate histone H3K23 and exert an oncogenic role in several tumor types including breast cancer where KAT6A is frequently amplified/overexpressed.
Khan, S, Chung, CY, Wang, Z, Zhang, Y, Tsaparikos, K, Brodsky, O, Johnson, E, Wang, H, Nady, N, Rickard, A, Greasley, S, Cao, J, Petrovic, J, Sharma, S, et al., Uryu, S   +15 more
core   +1 more source

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Nature Communications, 2022
Here the authors show phosphorylation of heat shock factor 1 (HSF1) at S419 via the chromatin-bound kinase PLK1, promotes HSF1 recruitment of histone acetyltransferases and histone acetylation reader proteins TRIM33 and TRIM24, which actually also ...
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai   +8 more
doaj   +1 more source

Inhibition of histone acetyltransferase by glycosaminoglycans [PDF]

Journal of Cellular Biochemistry, 2008
AbstractHistone acetyltransferases (HATs) are a class of enzymes that participate in modulating chromatin structure and gene expression. Altered HAT activity has been implicated in a number of diseases, yet little is known about the regulation of HATs.
Jo Ann, Buczek-Thomas, Edward, Hsia, Celeste B, Rich, Judith A, Foster, Matthew A, Nugent   +4 more
openaire   +2 more sources

Expression of cPLAγ mRNA and protein differs the response of PBMC from severe and non-severe asthmatics to bacterial lipopolysaccharide and house dust mite allergen

International Journal of Immunopathology and Pharmacology, 2021
Chronic inflammation in asthmatics is initiated/exacerbated by many environmental factors, such as bacterial lipopolysaccharide and allergens. Phospholipase A 2 and histone acetyltransferase/deacetylases are enzymes involved in inflammatory process ...
Ewa Pniewska-Dawidczyk, Izabela Kupryś-Lipińska, Gabriela Turek, Dorota Kacprzak, Joanna Wieczfinska, Paulina Kleniewska, Piotr Kuna, Rafal Pawliczak   +7 more
doaj   +1 more source

Biological functions and therapeutic potential of acylation by histone acetyltransferases

Acta Materia Medica, 2023
Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression.
Nan Li, Clark Hamor, Yahang An, Licheng Zhu, Yusheng Gong, Yukimatsu Toh, Yusong R. Guo   +6 more
doaj   +1 more source

Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton, Becker, Peter, Ferreira, Roger   +2 more
core   +1 more source

Autoacetylation of the Histone Acetyltransferase Rtt109 [PDF]

Journal of Biological Chemistry, 2011
Rtt109 is a yeast histone acetyltransferase (HAT) that associates with histone chaperones Asf1 and Vps75 to acetylate H3K56, H3K9, and H3K27 and is important in DNA replication and maintaining genomic integrity. Recently, mass spectrometry and structural studies of Rtt109 have shown that active site residue Lys-290 is acetylated.
Brittany N, Albaugh, Kevin M, Arnold, Susan, Lee, John M, Denu   +3 more
openaire   +2 more sources

Acetylation of general transcription factors by histone acetyltransferases. [PDF]

Current Biology, 1997
The acetylation of histones increases the accessibility of nucleosomal DNA to transcription factors [1,2], relieving transcriptional repression [3] and correlating with the potential for transcriptional activity in vivo[4–7].
A. Imhof, Xiang-Jiao Yang, V. Ogryzko, Y. Nakatani, A. Wolffe, H. Ge   +5 more
semanticscholar   +2 more sources

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source