Results 51 to 60 of about 241,476 (303)

H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation [PDF]

, 2011
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied.
Richard J. Festenstein, Bonneil, Eric, Guillemette Benoit, Festenstein Richard J., Armstrong Harry, Festenstein, Richard J., Harry Armstrong, Imhof Axel, Armstrong, Harry, Richard J Festenstein, Drogaris, Paul, Axel Imhof, Verreault Alain, Kyoko Hiragami-Hamada, Drogaris Paul, Verreault, Alain, Benoit Guillemette, Thibault Pierre, Pierre Thibault, Lin Hsiu-Hsu Sophia, Hiragami-Hamada, Kyoko, Alain Verreault, Imhof, Axel, Paul Drogaris, Hsiu-Hsu Sophia Lin, Bonneil Éric, Eric Bonneil, Festenstein, Richard J, Hiragami-Hamada Kyoko, Guillemette, Benoit, Lin, Hsiu-Hsu Sophia, Thibault, Pierre   +31 more
core   +1 more source

Dissecting the roles of histone deacetylase 1 and 2 in the hematopoietic system [PDF]

, 2008
Reversible histone acetylation on lysine residues has been intensively studied as an epigenetic mark for gene activation in a variety of eukaryotes. Histone deacetylases (HDACs) act to repress gene expression by removing acetyl groups from histones and ...
Yamaguchi, Teppei
core   +1 more source

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

Molecular Neurodegeneration, 2017
Background The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer’s disease (AD). In addition to histone acetyltransferases (HATs) and histone deacetylases (HDACs), inhibitor of acetyltransferases (INHAT) can also ...
Gao-Shang Chai, Qiong Feng, Zhi-Hao Wang, Yu Hu, Dong-Sheng Sun, Xiao-Guang Li, Dan Ke, Hong-Lian Li, Gong-Ping Liu, Jian-Zhi Wang   +9 more
doaj   +1 more source

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Nature Communications, 2021
Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product.
Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner   +22 more
doaj   +1 more source

Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications

Research, 2023
Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA)
Sha Li, Nan Li, Jie He, Runxin Zhou, Zhimin Lu, Yizhi Jane Tao, Yusong R. Guo, Yugang Wang   +7 more
doaj   +1 more source

H3 K36 Methylation Helps Determine the Timing of Cdc45 Association with Replication Origins [PDF]

, 2009
BackgroundReplication origins fire at different times during S-phase. Such timing is determined by the chromosomal context, which includes the activity of nearby genes, telomeric position effects and chromatin structure, such as the acetylation state of ...
Mariotti, F.R., Maria Vogelauer, Francesca Romana Mariotti, Devanshi Jain, Pryde, F., Jain, D., Alastair Kerr, Kerr, A., Rebecca Curley, Curley, R., Vogelauer, M., Fiona Pryde   +11 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Identification of Long Chain Alkylidenemalonates as Novel Small Molecule Modulators of Histone Acetyltransferases [PDF]

, 2008
Pentadecylidenemalonate 1b, a simplified analogue of anacardic acid, was identified as the first mixed activator/inhibitor of histone acetyltransferases (HATs). It potentiates PCAF HAT activity while inhibiting those of p300/CBP and recombinant CBP.
Sabrina Castellano, MAI A., SBARDELLA, Gianluca, CASTELLANO S, ALTUCCI L, Angela Nebbioso, SBARDELLA G, MICELI M, VICIDOMINI C, Gianluca Sbardella, Caterina Vicidomini, NEBBIOSO, Angela, NEBBIOSO A, Marco Miceli, ROTILI, Dante, CASTELLANO, Sabrina, Lucia Altucci, ALTUCCI, Lucia, MAI, Antonello, ROTILI D   +19 more
core   +1 more source

Combinatorial H3K9acS10ph Histone Modification in IgH Locus S Regions Targets 14-3-3 Adaptors and AID to Specify Antibody Class-Switch DNA Recombination

Cell Reports, 2013
Class-switch DNA recombination (CSR) is central to the antibody response, in that it changes the immunoglobulin heavy chain (IgH) constant region, thereby diversifying biological effector functions of antibodies. The activation-induced cytidine deaminase
Guideng Li, Clayton A. White, Tonika Lam, Egest J. Pone, Daniel C. Tran, Ken L. Hayama, Hong Zan, Zhenming Xu, Paolo Casali   +8 more
doaj   +1 more source

Characterization of Histone Deacetylase Mechanisms in Cancer Development

Frontiers in Oncology, 2021
Over decades of studies, accumulating evidence has suggested that epigenetic dysregulation is a hallmark of tumours. Post-translational modifications of histones are involved in tumour pathogenesis and development mainly by influencing a broad range of ...
Rihan Hai, Rihan Hai, Liuer He, Liuer He, Guang Shu, Gang Yin   +5 more
doaj   +1 more source