Results 31 to 40 of about 33,126 (285)

Posttranslational modifications of Gcn5-like acetyltransferases in yeast and mammalian cells.

, 2022
Posttranslational modifications of Gcn5-like acetyltransferases in yeast and mammalian cells.
Michael Downey (6838643), Onyekachi E. Ononye (13803922)   +1 more
core   +1 more source

MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins

Nature Communications, 2023
Altered transcriptional machinery promotes aberrant self-renewal of non-stem hematopoietic progenitors. Here the authors show that AF10 fusion proteins cause aberrant self-renewal via ENL, which promotes leukemic transformation by binding to MOZ/MORF ...
Yosuke Komata, Akinori Kanai, Takahiro Maeda, Toshiya Inaba, Akihiko Yokoyama   +4 more
doaj   +1 more source

A Yeast Polyamine Acetyltransferase [PDF]

Journal of Biological Chemistry, 2005
An uncharacterized yeast gene has been shown to encode a polyamine acetyltransferase and named PAA1. The recombinant Paa1 protein readily acetylates various polyamines such as putrescine, spermidine, and spermine. paa1 mutants are viable and grow normally under standard conditions.
Bingsheng, Liu, Ann, Sutton, Rolf, Sternglanz   +2 more
openaire   +2 more sources

Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases

, 2022
Histone lysine methyltransferases and acetyltransferases are two classes of epigenetic enzymes that play pivotal roles in human gene regulation. Although they both recognise and posttranslationally modify lysine residues in histone proteins, their ...
Boltje, Thomas J., Hintzen, Jordi C. J., Langens, Sabine G. H. A., White, Paul B., Maas, Marijn N., Merx, Jona, Mecinović, Jasmin; id_orcid   +6 more
core   +1 more source

Transcription Factor Acetylation and Cell Fate Control: A Molecular Switch in Hematopoiesis and Myogenesis

Frontiers in Bioscience-Landmark
Transcription factor acetylation is a critical yet often overlooked regulator of cell fate. Although traditionally studied in the context of histone modifications, many acetyltransferases and deacetylases also modify transcription factors directly ...
Pegah Ghavidel, Yassine Abdelmalki, Marie-Claude Sincennes   +2 more
doaj   +1 more source

Polyglutamine Disease: Acetyltransferases Awry

, 2002
Recent evidence indicates that inhibition of histone acetyltransferases may be a primary cause of cellular pathogenesis in polyglutamine diseases such as Huntington disease; the results raise the possibility that pharmacologic manipulation of protein ...
Hughes, Robert E., Robert E. Hughes
core   +1 more source

Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)

, 2014
Histone acetyltransferases (HATs) are interesting targets for the treatment of cancer and HIV infections but reports on selective inhibitors are very limited.
Robaa, Dina, Jung, Manfred, Hoffmann, Inga, Furdas, Silviya Dimitrova   +3 more
core   +2 more sources

Phenotypic Differentiation Within the aac(6′) Aminoglycoside Resistance Gene Family Suggests a Novel Subtype IV of Contemporary Clinical Relevance

Antibiotics
Background: Whole genome sequencing of clinical bacterial isolates holds promise in predicting their susceptibility to antibiotic therapy, based on a detailed understanding of the phenotypic manifestation of genotypic variation.
Michel Plattner, Maurizio Catelani, Sarah-Lisa Gmür, Maximilian Hartmann, Fatmanur Kiliç, Klara Haldimann, David Crich, Sven N. Hobbie   +7 more
doaj   +1 more source

Investigations of N-acetyltransferases in human hepatocytes and rat models.

, 2005
This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V).
Walraven, Jason Matthew
core   +1 more source

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

Stem Cells International, 2018
Protein acetylation is one of the most important posttranslational modifications catalyzed by acetyltransferases and deacetylases, through the addition and removal of acetyl groups to lysine residues. Lysine acetylation can affect protein-nucleic acid or
Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo   +2 more
doaj   +1 more source