Results 31 to 40 of about 35,074 (278)
Transcription shapes genome-wide histone acetylation patterns
Nature Communications, 2021 Histone acetylation is a ubiquitous hallmark of transcription. Here the authors provide evidence that the majority of histone acetylation is dependent on transcription, specifically due to the requirement of RNAPII for the recruitment and activity of ...
Benjamin J. E. Martin +6 more
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Acetyltransferases and tumour suppression [PDF]
Breast Cancer Research, 2000 The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrating a role for p300 in human tumours was lacking until the recently publication by Gayther et al, which strongly supports a role for p300 as a ...
Phillips, A C, Vousden, Karen H
openaire +2 more sources
PanM, an Acetyl-Coenzyme A Sensor Required for Maturation of
mBio, 2012 Coenzyme A (CoA) is essential for cellular chemistry in all forms of life. The pantothenate moiety of CoA is generated from the condensation of pantoate and β-alanine.
Tara N. Stuecker +2 more
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A Yeast Polyamine Acetyltransferase [PDF]
Journal of Biological Chemistry, 2005 An uncharacterized yeast gene has been shown to encode a polyamine acetyltransferase and named PAA1. The recombinant Paa1 protein readily acetylates various polyamines such as putrescine, spermidine, and spermine. paa1 mutants are viable and grow normally under standard conditions.
Bingsheng, Liu +2 more
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, 2020 p300 and CREB-binding protein (CBP) are ubiquitously expressed pleiotropic lysine acetyltransferases and play a key role as transcriptional co-activators that are essential for a multitude of cellular processes.
Zhifeng Chen (2340808) +13 more
core +5 more sources
MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins
Nature Communications, 2023 Altered transcriptional machinery promotes aberrant self-renewal of non-stem hematopoietic progenitors. Here the authors show that AF10 fusion proteins cause aberrant self-renewal via ENL, which promotes leukemic transformation by binding to MOZ/MORF ...
Yosuke Komata +4 more
doaj +1 more source
Metagenomics-Based Analysis of Formation Patterns of Ester Compounds during Fermentation of Qingxiangxing Baijiu [PDF]
Shipin KexueIn this study, metagenomics combined with headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) was employed to investigate the dynamic changes in four ethyl esters (ethyl lactate, ethyl acetate, ethyl butyrate, and ...
SHEN Jijian, REN Yuting, QIAO Meiling, SUN Ziyu, CHEN Zhongjun, Mandlaa
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, 2022 Histone lysine methyltransferases and acetyltransferases are two classes of epigenetic enzymes that play pivotal roles in human gene regulation. Although they both recognise and posttranslationally modify lysine residues in histone proteins, their ...
Boltje, Thomas J. +6 more
core +1 more source
AntibioticsBackground: Whole genome sequencing of clinical bacterial isolates holds promise in predicting their susceptibility to antibiotic therapy, based on a detailed understanding of the phenotypic manifestation of genotypic variation.
Michel Plattner +7 more
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Frontiers in Bioscience-LandmarkTranscription factor acetylation is a critical yet often overlooked regulator of cell fate. Although traditionally studied in the context of histone modifications, many acetyltransferases and deacetylases also modify transcription factors directly ...
Pegah Ghavidel +2 more
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