Communications Biology, 2022 A comprehensive functional and structural study of the Antibiotic_NAT family of aminoglycoside acetyltransferases provides new insight into the molecular mechanisms underlying resistance to existing and emerging aminoglycoside antibiotics.
Peter J. Stogios +11 more
doaj +1 more source
Different adaptation strategies of two citrus scion/rootstock combinations in response to drought stress [PDF]
, 2017 Scion/rootstock interaction is important for plant development and for breeding programs. In this context, polyploid rootstocks presented several advantages, mainly in relation to biotic and abiotic stresses.
Bonatto, Diego +6 more
core +4 more sources
Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme
IUCrJ, 2014 Capsular polysaccharides (CPSs) are protective structures on the surfaces of many Gram-negative bacteria. The principal CPS of the human pathogen and Tier 1 select agent Burkholderia pseudomallei consists of a linear repeat of –3)-2-O-acetyl-6-deoxy-β-d ...
Mirella Vivoli +4 more
doaj +1 more source
MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
Nature Communications, 2023 Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH1.
Dustin C. Becht +18 more
doaj +1 more source
Identification of critical residues of the serotype modifying O-acetyltransferase of Shigella flexneri [PDF]
, 2016 BACKGROUND Thirteen serotypes of Shigella flexneri (S. flexneri) have been recognised, all of which are capable of causing bacillary dysentery or shigellosis. With the emergence of the newer S.
Thanweer, Farzaana, Verma, Naresh K
core +1 more source
NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD +3 more
openaire +2 more sources
Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]
, 2014 The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat +13 more
core +2 more sources
NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD +3 more
openaire +2 more sources
PLoS ONE, 2014 An important cause of bacterial resistance to aminoglycoside antibiotics is the enzymatic acetylation of their amino groups by acetyltransferases, which abolishes their binding to and inhibition of the bacterial ribosome. Enhanced intracellular survival (
Oleg V Tsodikov +2 more
doaj +1 more source
Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases.
PLoS Computational Biology, 2020 The enzymes of the GCN5-related N-acetyltransferase (GNAT) superfamily count more than 870 000 members through all kingdoms of life and share the same structural fold.
Bojan Krtenic +3 more
doaj +1 more source