Results 11 to 20 of about 30,339 (261)
The BRCA2 is a histone acetyltransferase [PDF]
Oncogene, 1998 Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
H, Siddique +3 more
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A synopsis of eukaryotic Nα-terminal acetyltransferases: nomenclature, subunits and substrates [PDF]
BMC Proceedings, 2009 We have introduced a consistent nomenclature for the various subunits of the NatA-NatE N-terminal acetyltransferases from yeast, humans and other eukaryotes.
Polevoda Bogdan +2 more
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Acetyltransferases and tumour suppression [PDF]
Breast Cancer Research, 2000 The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrating a role for p300 in human tumours was lacking until the recently publication by Gayther et al, which strongly supports a role for p300 as a ...
Phillips, A C, Vousden, Karen H
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Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme
IUCrJ, 2014 Capsular polysaccharides (CPSs) are protective structures on the surfaces of many Gram-negative bacteria. The principal CPS of the human pathogen and Tier 1 select agent Burkholderia pseudomallei consists of a linear repeat of –3)-2-O-acetyl-6-deoxy-β-d ...
Mirella Vivoli +4 more
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Communications Biology, 2022 A comprehensive functional and structural study of the Antibiotic_NAT family of aminoglycoside acetyltransferases provides new insight into the molecular mechanisms underlying resistance to existing and emerging aminoglycoside antibiotics.
Peter J. Stogios +11 more
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MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
Nature Communications, 2023 Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH1.
Dustin C. Becht +18 more
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PLoS ONE, 2014 An important cause of bacterial resistance to aminoglycoside antibiotics is the enzymatic acetylation of their amino groups by acetyltransferases, which abolishes their binding to and inhibition of the bacterial ribosome. Enhanced intracellular survival (
Oleg V Tsodikov +2 more
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Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases.
PLoS Computational Biology, 2020 The enzymes of the GCN5-related N-acetyltransferase (GNAT) superfamily count more than 870 000 members through all kingdoms of life and share the same structural fold.
Bojan Krtenic +3 more
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Transcription shapes genome-wide histone acetylation patterns
Nature Communications, 2021 Histone acetylation is a ubiquitous hallmark of transcription. Here the authors provide evidence that the majority of histone acetylation is dependent on transcription, specifically due to the requirement of RNAPII for the recruitment and activity of ...
Benjamin J. E. Martin +6 more
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PanM, an Acetyl-Coenzyme A Sensor Required for Maturation of
mBio, 2012 Coenzyme A (CoA) is essential for cellular chemistry in all forms of life. The pantothenate moiety of CoA is generated from the condensation of pantoate and β-alanine.
Tara N. Stuecker +2 more
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