Results 1 to 10 of about 360,616 (327)
Research advances of histone deacetylases in acute kidney injury
Linchuang shenzangbing zazhi, 2022 Histone deacetylases （HDACs） are expressed by silencing the deacetylation of histone lysine.HDACs can also deacetylate non-histone proteins and regulate cell biological functions.Abnormal function of HDACs is closely correlated with the occurrence and ...
Deng Fang-jing, Zhu Jie-fu, Wu Xiong-fei
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Prognosis Analysis of Histone Deacetylases mRNA Expression in Ovarian Cancer Patients
Journal of Cancer, 2018 Histone deacetylases modulate the dynamic balance of histone acetylation and deacetylation in cells, which participate in epigenetic regulations. Accumulated evidence has demonstrated that histone deacetylases are associated with angiogenesis, cell ...
Lulu Zhou +6 more
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The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair
Nucleic Acids Research, 2016 Histone/protein deacetylases play multiple roles in regulating gene expression and protein activation and stability. Their deregulation during cancer initiation and progression cause resistance to therapy. Here, we review the role of histone deacetylases
W. Roos, A. Krumm
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Histone Deacetylases and Their Inhibition in Candida Species
Frontiers in Microbiology, 2016 Fungi are generally benign members of the human mucosal flora or live as saprophytes in the environment. However, they can become pathogenic, leading to invasive and life threatening infections in vulnerable patients. These invasive fungal infections are
C. Garnaud +4 more
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Dual Inhibitors Targeting DNA and Histone Deacetylases
Pharmaceutical Fronts, 2020 Histone deacetylases (HDACs) regulate the acetylation status of histones and structural status of chromatin. The chromatin structure becomes relaxed after inhibition of HDAC, leading to DNA exposed to DNA disrupting agents, and eventually causing DNA ...
Chen Chen +3 more
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Critical reviews in oncogenesis, 2015 In recent years, it has become widely recognized that histone modification plays a pivotal role in controlling gene expression, and is involved in a wide spectrum of disease regulation.
Hong-Ping Chen, Y. Zhao, Ting C Zhao
semanticscholar +1 more source
BMC Biology, 2006 Background Histone deacetylases are enzymes that modify core histones and play key roles in transcriptional regulation, chromatin assembly, DNA repair, and recombination in eukaryotes. Three types of related histone deacetylases (classes 1, 2, and 4) are
Vervoort Michel, Ledent Valérie
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Histone deacetylases: structural determinants of inhibitor selectivity.
Drug Discovery Today, 2015 Histone deacetylases (HDACs) are epigenetic targets with an important role in cancer, neurodegeneration, inflammation, and metabolic disorders. Although clinically effective HDAC inhibitors have been developed, the design of inhibitors with the desired ...
Carmina Micelli, G. Rastelli
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Histone deacetylases and their role in motor neuron degeneration
Frontiers in Cellular Neuroscience, 2013 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by the progressive loss of motor neurons. The cause of this selective neuronal death is unknown, but transcriptional dysregulation is recently emerging as an ...
Rafael eLazo-Gómez +3 more
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Genes & cancer, 2015 The development of B and T cells from hematopoietic precursors and the regulation of the functions of these immune cells are complex processes that involve highly regulated signaling pathways and transcriptional control.
Leila Haery +2 more
semanticscholar +1 more source