Results 1 to 10 of about 53,170 (215)
Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease
Brain Sciences, 2022 Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that is increasingly becoming a global threat to the health and life of the elderly worldwide.
Bin He +2 more
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Mechanism-based inhibition of zinc-dependent histone deacetylases [PDF]
RSC Chemical BiologyThe hallmark of a mechanism-based inhibitor is a chemical transformation that occurs upon binding in an enzyme active site that typically yields a more potent inhibitory species. A mechanism-based enzyme inhibitor can be a closely-related analogue of the
David W. Christianson
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Histone deacetylases in cancer metabolic reprogramming [PDF]
Experimental and Molecular MedicineCancer cells undergo extensive metabolic reprogramming to sustain rapid proliferation and adapt to heterogeneous tumour microenvironments. These metabolic alterations are tightly linked to epigenetic regulation, which reshapes gene expression and ...
Yu Hyun Jeon +6 more
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Research Progress on the Mechanism of Histone Deacetylases in Ferroptosis of Glioma [PDF]
Oncology ReviewsGlioma is the most prevalent primary malignant tumor of the central nervous system. While traditional treatment modalities such as surgical resection, radiotherapy, and chemotherapy have made significant advancements in glioma treatment, the prognosis ...
Meng Ma +6 more
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Potential of histone deacetylase inhibitors for the therapy of ovarian cancer
Frontiers in Oncology, 2022 Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemotherapy increase patient mortality.
Fengyi Guo, Hongjing Wang, Hongjing Wang
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Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke
Biomedicines, 2021 Cerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4.
Svetlana Demyanenko +2 more
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Asian Pacific Journal of Cancer Biology, 2020 Objective: DNA methylation, the covalent addition of a methyl group to cytosine, and histone modification play an important role in the establishment and maintenance of the program of gene expression.
Masumeh Sanaei, Fraidoon Kavoosi
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Histone deacetylases facilitate the accurate repair of broken forks
Molecular & Cellular Oncology, 2020 We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and ...
Belén Gómez-González +2 more
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BMC Plant Biology, 2009 Background Although histone deacetylases from model organisms have been previously identified, there is no clear basis for the classification of histone deacetylases under the RPD3/HDA1 superfamily, particularly on plants.
Yu Chun-Wei +2 more
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Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis
Pharmaceuticals, 2022 Schistosomiasis is a major neglected parasitic disease that affects more than 240 million people worldwide and for which the control strategy consists of mass treatment with the only available drug, praziquantel.
Ehab Ghazy +4 more
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