Results 41 to 50 of about 360,616 (327)

Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

Reproductive Biology and Endocrinology, 2020
Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation. The human
Palak Gujral, Vishakha Mahajan, Abbey C Lissaman, A. Ponnampalam   +3 more
semanticscholar   +1 more source

Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis

Pharmaceuticals, 2022
Schistosomiasis is a major neglected parasitic disease that affects more than 240 million people worldwide and for which the control strategy consists of mass treatment with the only available drug, praziquantel.
Ehab Ghazy, Mohamed Abdelsalam, Dina Robaa, Raymond J. Pierce, Wolfgang Sippl   +4 more
doaj   +1 more source

The application of histone deacetylases inhibitors in glioblastoma

Journal of experimental & clinical cancer research : CR, 2020
The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant phenotype without altering genotype.
Rui Chen, Meng-Xian Zhang, Yangmei Zhou, Wenjing Guo, Ming Yi, Zi-Yan Zhang, Yanpeng Ding, Ya-Li Wang   +7 more
semanticscholar   +1 more source

Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]

, 2012
The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Julia Metzner, Metzner, Julia, Nicole Schnur, Manuel Grez, Grez, Manuel, Katryniok, Careen, Careen Katryniok, Bernd L. Sorg, Dieter Steinhilber, Laura Pufahl, Sorg, Bernd Lothar, Pufahl, Laura, Schnur, Nicole, Steinhilber, Dieter   +13 more
core   +1 more source

Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]

, 2009
Cigarette smoke (CS)-induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David, Yao, Hongwei, Rahman, Irfan, Seagrave, JeanClare, March, Thomas H   +4 more
core   +1 more source

Inhibition of Histone Deacetylases [PDF]

, 2011
Lysine acetylation of histones is one of the major epigenetic regulators of chromatin conformation and gene expression. The dynamic nature of histone acetylation is determined by the counterbalancing activity of histone acetyltransferase and histone deacetylase (HDAC) enzymes.
Yi, Huang, Patrick G, Shaw, Nancy E, Davidson   +2 more
openaire   +4 more sources

Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts

Haematologica, 2010
Background During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are ...
Peng Ji, Victor Yeh, Tzutzuy Ramirez, Maki Murata-Hori, Harvey F. Lodish   +4 more
doaj   +1 more source

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]

, 2008
The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
P. D. Soldato, L. Hudak, A. Atmaca, Hudak, Lukasz, A. Sparatore, S. A. Wedel, R. A. Blaheta, Jüngel, Eva, Sparatore, Anna, Blaheta, Roman A., Wedel, Steffen Alexander, D. Jonas, S. E. Al Batran, E. Juengel, Jonas, Dietger, Soldato, Piero Del, Batran, Salah-Eddin al-, Atmaca, Akin   +17 more
core   +1 more source

Histone deacetylase inhibitors

Journal of Education, Health and Sport, 2020
The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence ...
Marzena Baran, Paulina Anna Miziak, Katarzyna Bonio   +2 more
doaj   +1 more source

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Nature reviews genetics, 2009
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription.
M. Haberland, Rusty L. Montgomery, E. Olson   +2 more
semanticscholar   +1 more source