Results 21 to 30 of about 51,098 (257)
iScience, 2021 Summary: Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) driven by viruses or bacteria, as well as in numerous immune-mediated disorders.
Valentina Poli +10 more
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Histone Deacetylase Inhibitors [PDF]
Journal of Thoracic Oncology, 2011 Histone modification and DNA methylation are critical events that determine gene expression. Histone deacetylases (HDAC) render several critical genes transcriptionally inactive by conferring a “hyperwound” configuration. HDAC inhibition leads to unwinding of the DNA and makes it available to the transcriptional machinery for expression of a number of ...
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Frontiers in Oncology, 2022 Thyroid cancer is a common malignancy of the endocrine system, with papillary thyroid cancer (PTC) being the most common type of pathology. The incidence of PTC is increasing every year.
Chongyang Chen +2 more
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Histone acetylation modifiers in the pathogenesis of Alzheimer’s disease
Frontiers in Cellular Neuroscience, 2015 It is becoming more evident that histone acetylation, as one of the epigenetic modifications or markers, plays a key role in the etiology of Alzheimer’s disease (AD).
Xi eLu +4 more
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Toxins, 2019 Histone acetylation is an important modification for the regulation of chromatin accessibility and is controlled by two kinds of histone-modifying enzymes: histone acetyltransferases (HATs) and histone deacetylases (HDACs). In filamentous fungi, there is
Xuejie Li, Lijie Pan, Bin Wang, Li Pan
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Histone Deacetylases in the Pathogenesis of Diabetic Cardiomyopathy
Frontiers in Endocrinology, 2021 The global burden of diabetes mellitus and its complications are currently increasing. Diabetic cardiomyopathy (DCM) is the main cause of diabetes mellitus associated morbidity and mortality; therefore, a comprehensive understanding of DCM development is
Xiangyu Ke +8 more
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Biotechnology & Biotechnological Equipment, 2018 Histone deacetylases (HDACs) catalyse the deacetylation of core histones and non-histone proteins. Histone deacetylases work in concert with histone acetyltransferases to modify the structure and function of chromatins, and regulate gene transcription ...
Botong Tong +3 more
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Beyond Histones: New Substrate Proteins of Lysine Deacetylases in Arabidopsis Nuclei
Frontiers in Plant Science, 2018 The reversible acetylation of lysine residues is catalyzed by the antagonistic action of lysine acetyltransferases and deacetylases, which can be considered as master regulators of their substrate proteins.
Magdalena Füßl +11 more
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Nature Communications, 2021 Current histone microarrays cannot be used to directly study the transient interactions of histone deacetylases (HDACs). Here, the authors show that hydroxamic acid-modified microarrays can capture HDACs, provide insights into their substrate specificity,
Carlos Moreno-Yruela +5 more
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Medicina, 2021 Background andObjective: Epigenetic modifications are believed to play a significant role in the development of cancer progression, growth, differentiation, and cell death. One of the most popular histone deacetylases inhibitors (HDACIs), suberoylanilide
Umamaheswari Natarajan +2 more
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