Results 21 to 30 of about 360,616 (327)
Histone Deacetylases and Their Inhibitors in Cancer Epigenetics
Diseases (Basel, Switzerland), 2019 Histone deacetylases (HDAC) and histone deacetylase inhibitors (HDACi) have greatly impacted the war on cancer. Their role in epigenetics has significantly altered the development of anticancer drugs used to treat the most rare, persistent forms of ...
Kelly N. Hassell
exaly +2 more sources
Targeting Class I Histone Deacetylases in a “Complex” Environment
Trends in Pharmacological Sciences, 2017 Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have potential in the treatment of many other diseases including HIV infection, Alzheimer's disease, and Friedreich's ataxia.
Louise Fairall +2 more
exaly +2 more sources
Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy
Nutrients, 2018 Cancer initiation and progression are the result of genetic and/or epigenetic alterations. Acetylation-mediated histone/non-histone protein modification plays an important role in the epigenetic regulation of gene expression.
Anupam Bishayee +2 more
exaly +2 more sources
Phylogenetic analysis, subcellular localization, and expression patterns of RPD3/HDA1 family histone deacetylases in plants [PDF]
BMC Plant Biology, 2009 Background Although histone deacetylases from model organisms have been previously identified, there is no clear basis for the classification of histone deacetylases under the RPD3/HDA1 superfamily, particularly on plants.
Yu Chun-Wei +2 more
doaj +2 more sources
Histone Deacetylases in Retinoblastoma. [PDF]
Int J Mol SciRetinoblastoma, a pediatric ocular malignancy, presents significant challenges in comprehending its molecular underpinnings and targeted therapeutic approaches. The dysregulated activity of histone deacetylases (HDACs) has been associated with retinoblastoma pathogenesis, influencing critical cellular processes like cell cycle regulation or retinal ...
Lisek M +4 more
europepmc +3 more sources
Histone deacetylases and cancer [PDF]
Oncogene, 2007 Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. By removal of acetyl groups from histones, HDACs create a non-permissive chromatin conformation that prevents the transcription of genes that encode proteins involved in tumorigenesis. In addition to histones,
M. A. Glozak, E. Seto
semanticscholar +3 more sources
Plant Responses to Abiotic Stress Regulated by Histone Deacetylases
Frontiers in Plant Science, 2017 In eukaryotic cells, histone acetylation and deacetylation play an important role in the regulation of gene expression. Histone acetylation levels are modulated by histone acetyltransferases and histone deacetylases (HDACs).
Ming Luo +5 more
doaj +2 more sources
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases [PDF]
Biochemical Pharmacology, 2015 Lysine acetylations are reversible posttranslational modifications of histone and non-histone proteins that play important regulatory roles in signal transduction cascades and gene expression.
T. van den Bosch +10 more
semanticscholar +3 more sources
Histone deacetylases (HDACs) and brain function [PDF]
, 2015 Modulation of gene expression is a constant and necessary event for mammalian brain function. An important way of regulating gene expression is through the remodeling of chromatin, the complex of DNA, and histone proteins around which DNA wraps.
C. Volmar, C. Wahlestedt
semanticscholar +2 more sources