A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma [PDF]
Frontiers in Oncology, 2023 This review aims to summarize the putative role of histone deacetylases (HDACs) in rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by elucidating and highlighting known oncogenic pathways, mechanisms of resistance, and the ...
Omar Selim +7 more
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Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma [PDF]
Frontiers in Cell and Developmental Biology, 2020 Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone acetylation caused by deregulated HDAC expression and activity is known to promote tumor progression in
Monica Phimmachanh +6 more
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Role of histone deacetylase inhibitors in non-neoplastic diseases [PDF]
HeliyonBackground: Epigenetic dysregulation has been implicated in the development and progression of a variety of human diseases, but epigenetic changes are reversible, and epigenetic enzymes and regulatory proteins can be targeted using small molecules ...
Chunxiao Zhou +7 more
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Clinical Toxicities of Histone Deacetylase Inhibitors
Pharmaceuticals, 2010 The HDAC inhibitors are a new family of antineoplastic agents. Since the entry of these agents into our therapeutic armamentarium, there has been increasing interest in their use.
Richard L. Piekarz +4 more
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Histone deacetylase inhibitors for leukemia treatment: current status and future directions [PDF]
European Journal of Medical ResearchLeukemia remains a major therapeutic challenge in clinical oncology. Despite significant advancements in treatment modalities, leukemia remains a significant cause of morbidity and mortality worldwide, as the current conventional therapies are ...
Mohammad-Salar Hosseini +4 more
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Current treatment strategies targeting histone deacetylase inhibitors in acute lymphocytic leukemia: a systematic review [PDF]
Frontiers in OncologyAcute lymphocytic leukemia is a hematological malignancy that primarily affects children. Long-term chemotherapy is effective, but always causes different toxic side effects.
Yingjun Zhang +19 more
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Histone deacetylase inhibitors
Journal of Education, Health and Sport, 2020 The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence ...
Marzena Baran +2 more
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Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy. [PDF]
PLoS ONE, 2014 Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations.
Michael Bordonaro +3 more
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Medicinal chemistry of histone deacetylase inhibitors [PDF]
Arhiv za farmaciju, 2021 Today, we are witnessing an explosion of scientific concepts in cancer chemotherapy. It has been considered for a long time that genetic instability in cancer should be treated with drugs that directly damage the DNA. Understanding the molecular basis of
Ružić Dušan +3 more
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Histone Deacetylase Inhibitors [PDF]
Journal of Thoracic Oncology, 2011 Histone modification and DNA methylation are critical events that determine gene expression. Histone deacetylases (HDAC) render several critical genes transcriptionally inactive by conferring a “hyperwound” configuration. HDAC inhibition leads to unwinding of the DNA and makes it available to the transcriptional machinery for expression of a number of ...
BRADNER JAMES ELLIOT, MAZITSCHEK RALPH
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