Results 31 to 40 of about 138,704 (292)
Histone Deacetylase Inhibitors: Synthesis of Tetrapeptide Analogue SAHA/TPX
E-Journal of Chemistry, 2011 The inhibition of HDAC (histone deacetylase) activity by specific inhibitors induces growth arrest, differentiation and apoptosis of transformed or several cancer cells. Some of these inhibitors are in clinical trial at phase I or phase II. The discovery
Lynda Ekou +3 more
doaj +1 more source
HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors
Frontiers in Physiology, 2018 Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini +5 more
doaj +1 more source
Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke
Biomedicines, 2021 Cerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4.
Svetlana Demyanenko +2 more
doaj +1 more source
Histone Deacetylase Inhibitors and Diabetic Kidney Disease
International Journal of Molecular Sciences, 2018 Despite recent clinical trial advances and improvements in clinical care, kidney disease due to diabetes remains the most common cause of chronic kidney failure worldwide.
Mitchell J. Hadden, A. Advani
semanticscholar +1 more source
New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer
Journal of Hematology & Oncology, 2009 DNA methylation and histone acetylation are two well known epigenetic chromatin modifications. Epigenetic agents leading to DNA hypomethylation and histone hyperacetylation have been approved for treatment of hematological disorders.
Ma Yuehua, Cang Shundong, Liu Delong
doaj +1 more source
Epigenetics of cervical cancer. An overview and therapeutic perspectives
Molecular Cancer, 2005 Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic drugs, surgery, and radiation; therefore, testing of molecular ...
Cetina Lucely +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Entinostat-Bortezomib Hybrids against Multiple Myeloma
Molecules, 2023 Although proteasome inhibitors have emerged as the therapeutic backbone of multiple myeloma treatment, patients often relapse and become drug refractory. The combination between proteasome and histone deacetylase inhibitors has shown to be more efficient
Angelica Ferro +4 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence
Anticancer Research, 2018 Uveal melanoma is the most common intraocular malignancy in adults, representing approximately 3% of all melanoma cases. Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival rates remain poor. Acetylation
M. Moschos +8 more
semanticscholar +1 more source