Results 51 to 60 of about 830,895 (193)

Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors [PDF]

, 2019
Study describes the use of a non-cytotoxic dose of histone deacetylase (HDAC) inhibitors to induce pulmonary carcinoid somatostatin receptor subtype 2 (SSTR2) expression to diagnose pulmonary ...
Jason Whitt, Renata Jaskula-Sztul, Jaskula-Sztul, Renata, Chang, Alexander W., Aweda, Tolulope, Cheng, Eric Y., Lapi, Suzanne E., Guenter, Rachael E., Danilea M. Carmona Matos, Carmona Matos, Danilea M., Chen, Herbert, Suzanne E. Lapi, Matos, Danilea M. Carmona, Whitt, Jason, Alexander W. Chang, X. Margaret Liu, Eric Y. Cheng, Rachael E. Guenter, Tolulope Aweda, Liu, X. Margaret, Herbert Chen   +20 more
core   +1 more source

Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis

Haematologica, 2014
Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological ...
Marinus R. Heideman, Cesare Lancini, Natalie Proost, Eva Yanover, Heinz Jacobs, Jan-Hermen Dannenberg   +5 more
doaj   +1 more source

Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. [PDF]

PLoS ONE, 2014
In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells.
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga   +13 more
doaj   +1 more source

Clinical Toxicities of Histone Deacetylase Inhibitors

Pharmaceuticals, 2010
The HDAC inhibitors are a new family of antineoplastic agents. Since the entry of these agents into our therapeutic armamentarium, there has been increasing interest in their use.
Richard L. Piekarz, John J. Wright, Susan E. Bates, Srividya Subramanian, Igor Espinoza-Delgado   +4 more
doaj   +1 more source

Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity [PDF]

, 2012
The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Pirrie, L, Sonia Lain, Major, LL, Zubriene, Asta, Lebl, T, Matulis, Daumantas, Lisa Pirrie, Morkunaite, Vaida, Tomas Lebl, McCarthy, Anna R., Asta Zubrienė, Louise L. Major, Matulis, D, Lain, Sonia, Daumantas Matulis, Morkunaite, V, Nicholas J. Westwood, Vaida Morkūnaitė, Major, Louise L., Westwood, NJ, Anna R. McCarthy, McCarthy, AR, Zubriene, A, Lebl, Tomas, Lain, S, Westwood, Nicholas J., Pirrie, Lisa, Major, Louise L.; id_orcid, Westwood, Nicholas J.; id_orcid, Lebl, Tomas; id_orcid   +29 more
core   +1 more source

Functional characterization of Candida albicans Hos2 histone deacetylase [v3; ref status: indexed, http://f1000r.es/3xh]

F1000Research, 2014
Candida albicans is a mucosal commensal organism capable of causing superficial (oral and vaginal thrush) infections in immune normal hosts, but is a major pathogen causing systemic and mucosal infections in immunocompromised individuals.
G Karthikeyan, Maneesh Paul-Satyaseela, Nachiappan Dhatchana Moorthy, Radha Gopalaswamy, Shridhar Narayanan   +4 more
doaj   +1 more source

Acetylation site specificities of lysine deacetylase inhibitors in human cells [PDF]

, 2015
This work was supported by the Hallas Møller Investigator grant from the Novo Nordisk Foundation to C.C. S.A.W. and P.B. were supported by individual postdoctoral grants from the Danish Research Council (FSS: 10-085134, FSS: 12-12610). C.C.
Sebastian A Wagner, Jensen, Lars J., Jensen, Lars J, Chunaram Choudhary, Qi, Yun, Sonia Lain, Wagner, Sebastian A, Weinert, Brian T., James E Bradner, McCarthy, Anna R, Mann, Matthias, Yasuyuki Miyake, Westwood, Nicholas J, Schölz, Christian, Wagner, Sebastian A., Choudhary, Chunaram, Choudhary, Chuna Ram, Matthias, Patrick, Bradner, James E, Anna R McCarthy, Werner Streicher, Weinert, Brian Tate, Lain, Sonia, Bradner, James E., Matthias Mann, Nicholas J Westwood, Lars J Jensen, Jürgen Cox, Westwood, Nicholas James, Brian T Weinert, Cox, Jürgen, Christian Schölz, Streicher, Werner, McCarthy, Anna Rose, Lain, Sonya, Beli, Petra, Qi, Jun, Petra Beli, Jun Qi, Miyake, Yasuyuki, Patrick Matthias, Westwood, N., Miyake, Y., Scholz, C, Schölz C, Bradner JE, Lain S, Wagner, SA, Jensen, LJ, Mann, M., Choudhary, C., Streicher, W, Beli P, Westwood, NJ, Streicher W, Jensen, L., Qi, J, McCarthy AR, Qi, J., Qi J, Choudhary C, Lain, S., Weinert, B., Matthias, P., Mann M, Westwood NJ, Matthias P, McCarthy, A., Miyake, Y, Cox, J., Wagner SA, Schölz, C., Streicher, W., Weinert, BT, Beli, P, Weinert BT, Bradner, J., Cox J, Wagner, S., Beli, P., McCarthy, AR, Miyake Y, Jensen LJ, Westwood, Nicholas James; id_orcid   +83 more
core   +1 more source

The histone deacetylase family in health and disease

Signal Transduction and Targeted Therapy
Zinc-dependent classical histone deacetylases, including Classes I, II, and IV, are ubiquitously present in mammals and play vital roles in numerous biological processes.
Ri Wen, Yu-Hang Yang, Tao Zhang, Sen-Yu Zhang, Xin-Ru Yang, Li-Ying Zhang, Peng-Hui Hao, Yue Zheng, Ni Yang, Tie-Ning Zhang   +9 more
doaj   +1 more source

Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation

Haematologica, 2010
Background The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years.
Marije Bartels, Christian R. Geest, Marc Bierings, Miranda Buitenhuis, Paul J. Coffer   +4 more
doaj   +1 more source

Functional characterization of Candida albicans Hos2 histone deacetylase [v2; ref status: indexed, http://f1000r.es/3i2]

F1000Research, 2014
Candida albicans is a mucosal commensal organism capable of causing superficial (oral and vaginal thrush) infections in immune normal hosts, but is a major pathogen causing systemic and mucosal infections in immunocompromised individuals.
G Karthikeyan, Maneesh Paul-Satyaseela, Nachiappan Dhatchana Moorthy, Radha Gopalaswamy, Shridhar Narayanan   +4 more
doaj   +1 more source