Results 61 to 70 of about 830,895 (193)

Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites

International Journal for Parasitology: Drugs and Drug Resistance, 2015
Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and gene expression as well ...
Jessica A. Engel, Amy J. Jones, Vicky M. Avery, Subathdrage D.M. Sumanadasa, Susanna S. Ng, David P. Fairlie, Tina S. Adams, Katherine T. Andrews   +7 more
doaj   +1 more source

Butyrate Histone Deacetylase Inhibitors

BioResearch Open Access, 2012
In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in gynecological cancer cells, inhibiting DNA synthesis and cell growth in colonic tumor cell lines, suppressing hTERT mRNA expression and telomerase activity in human ...
Steliou, Kosta, Boosalis, Michael S., Perrine, Susan P., Sangerman, José, Faller, Douglas V.   +4 more
openaire   +3 more sources

Recent Prospectives of Anticancer Histone Deacetylase Inhibitors [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences, 2019
Histone deacetylases (HDACs) are common targets for cancer therapy as they are expressed in many forms of cancers; several research studies have been introduced discussing the design of small molecules that target this abnormal epigenetic changes ...
Shymaa Abbass, Heba Hassan, Mamdouh Mohamed, Gamal Moustafa, Gamal Abuo-Rahma   +4 more
doaj   +1 more source

HISTONE DEACETYLASE INHIBITORS FOR CANCER TREATMENT DRUG DEVELOPMENT IN CONTEMPORARY ONCOLOGY

, 2014
inhibitors as novel anticancer therapeutics D.R. Walkinshaw MSc * and X.J. Yang PhD* Histone deacetylase inhibitors represent a promising new class of compounds for the treatment of cancer.
Key Words, Histone Deacetylase
core  

Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Histone post-translational modification, mediated by histone acetyltransferases and deacetylases, is one of the most studied factors affecting gene expression.
Vanina A. Campo
doaj   +1 more source

Histone Deacetylase Inhibitors as Novel Anticancer Therapeutics

, 2008
Histone deacetylase inhibitors represent a promising new class of compounds for the treatment of cancer. Inhibitors of this kind currently under clinical evaluation mainly target the classical (Rpd3/Hda1) family of histone deacetylases.
D. R. Walkinshaw, X. J. Yang
core   +1 more source

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation

Scientific Reports, 2017
Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Brice J. Albert, Austin Niu, Rashmi Ramani, Garland R. Marshall, Paul A. Wender, Robert M. Williams, Lee Ratner, Alexander B. Barnes, George B. Kyei   +8 more
doaj   +1 more source

The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma [PDF]

, 2008
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortezomib in Hodgkin lymphoma (L428) and non-Hodgkin's ...
Kevin David, Lauren Mauro, Savita Bhalla, Sheila Prachand, Andrew Evens, Leo Gordon, Joseph Buggy, Sriram Balasubramanian, Mint Sirisawad, Richard Miller   +9 more
core  

Targeted inhibition of histone deacetylase 6 in inflammatory diseases

Thoracic Cancer, 2019
Targeting epigenetic modification of gene expression represents a promising new approach under investigation for the treatment of inflammatory diseases.
Jie Ran, Jun Zhou
doaj   +1 more source

Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies

European Journal of Medical Research
Histone deacetylation represents a significant epigenetic mechanism that involves the removal of acetyl groups from histones, subsequently influencing gene transcription.
Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wen Zhang, Feifeng Song, Ping Huang, Tong Xu   +7 more
doaj   +1 more source