Results 71 to 80 of about 830,895 (193)

Supplementary Data from UNC45A Confers Resistance to Histone Deacetylase Inhibitors and Retinoic Acid

, 2009
Supplementary Data from UNC45A Confers Resistance to Histone Deacetylase Inhibitors and Retinoic ...
Mirjam T. Epping (15085033), René Bernards (82847), Lars A.T. Meijer (15085036), Johannes L. Bos (9283986)   +3 more
core   +1 more source

Histone Deacetylase Inhibitors in Tumor Immunotherapy

, 2019
Background:With an increasing understanding of the antitumor immune response, considerable progress has been made in the field of tumor immunotherapy in the last decade.
Li-Ming Zhao, Jie-Huan Zhang
core   +1 more source

Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density.

PLoS ONE, 2010
Groucho (Gro) is a Drosophila melanogaster transcriptional corepressor that directly interacts with the histone deacetylase Rpd3. Although previous studies suggest that this interaction is required for repression of Gro-responsive reporters in cultured ...
Clint J Winkler, Alberto Ponce, Albert J Courey   +2 more
doaj   +1 more source

Rational drug design of histone deacetylase 6 inhibitors [PDF]

, 2018
Activity of the histone deacetylases (HDACs) has an essential influence on histone posttranslational modifications. Therefore, alterations in the structure and expression of HDACs isoforms are strongly related to the pathogenesis of inflammation ...
Ružić, Dušan, Nikolić, Katarina, Ganesan, A., Agbaba, Danica, Petković, Miloš   +4 more
core   +3 more sources

Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms [PDF]

Mukherjee A., Zamani F., Suzuki T.. Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms. Journal of Medicinal Chemistry 66, 11672 (2023); https://doi.org/10.1021/acs.jmedchem.3c01160.Because the overexpression of histone ...
Suzuki, Takayoshi, Zamani, Farzad, Mukherjee, Anirban   +2 more
core   +1 more source

Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts

Haematologica, 2010
Background During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are ...
Peng Ji, Victor Yeh, Tzutzuy Ramirez, Maki Murata-Hori, Harvey F. Lodish   +4 more
doaj   +1 more source

Histone deacetylase inhibitors: gathering pace

, 2006
Reversible histone acetylation is one of the key mechanisms involved in the epigenetic control of gene expression. A variety of recent studies has revealed a role for acetylation in a much broader repertoire of physiological processes, including ...
La Thangue, N., Carey, N.
core   +1 more source

Combination Therapy with Immune Checkpoint Inhibitors and Histone Deacetylase Inhibitors or Alkylating Agents. [PDF]

Cancer Manag Res
Markus Joerger,1 Kira-Lee Koster,1 Tomas Janik,2 Floris A de Jong3,4 1Department of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; 2Research & Development Department, Mundipharma Research Limited, Cambridge, UK ...
Joerger M, Koster KL, Janik T, de Jong FA.   +3 more
europepmc   +2 more sources

Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Various Disorders [PDF]

, 2019
Epigenetic modification acetylation or deacetylation of histone considered as an important element in various disorders. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are the enzymes which catalyse the acetylation and deacetylation ...
Anurag Sharma, Thakur Gurjeet Singh, Kajal Thapa, Amarjot Kaur Grewal, Savir Kumar, Sandeep Arora   +5 more
core   +1 more source

Histone Deacetylase Inhibitors: A Promising Therapeutic Alternative for Endometrial Carcinoma

, 2021
Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Epigenetic alterations are implicated in endometrial cancer development and progression.
Psilopatis, I., Giaginis, C., Pergaris, A., Theocharis, S.   +3 more
core