Results 11 to 20 of about 138,704 (292)
Histone Deacetylase Inhibitors [PDF]
Journal of Thoracic Oncology, 2011 Histone modification and DNA methylation are critical events that determine gene expression. Histone deacetylases (HDAC) render several critical genes transcriptionally inactive by conferring a “hyperwound” configuration. HDAC inhibition leads to unwinding of the DNA and makes it available to the transcriptional machinery for expression of a number of ...
BRADNER JAMES ELLIOT, MAZITSCHEK RALPH
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Histone deacetylase inhibitors
Journal of Education, Health and Sport, 2020 The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence ...
Marzena Baran +2 more
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Medicinal chemistry of histone deacetylase inhibitors [PDF]
Arhiv za farmaciju, 2021 Today, we are witnessing an explosion of scientific concepts in cancer chemotherapy. It has been considered for a long time that genetic instability in cancer should be treated with drugs that directly damage the DNA. Understanding the molecular basis of
Ružić Dušan +3 more
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Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy. [PDF]
PLoS ONE, 2014 Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations.
Michael Bordonaro +3 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial infarction are the most common causes of ischemia/reperfusion injury without ...
Zachary Pickell +3 more
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Haematologica, 2018 Histone deacetylase inhibitors are promising agents for various T-cell lymphomas, including cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and adult T-cell lymphoma/leukemia. CCR4 is an important therapeutic target molecule because mogamulizumab,
Akihiro Kitadate +6 more
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Haematologica, 2009 Histone deacetylase inhibitors are a class of anti-neoplastic agents that induce growth arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo.
David Ritchie +9 more
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Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. [PDF]
PLoS ONE, 2013 Neurotrophins and modifiers of chromatin acetylation and deacetylation participate in regulation of transcription during neuronal maturation and maintenance.
Samira Chandwani +5 more
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Frontiers in Immunology, 2021 Histone deacetylase inhibitors are currently the most studied drugs because of their beneficial effects on inflammatory response. Emerging data from numerous basic studies and clinical trials have shown that histone deacetylase inhibitors can suppress ...
Xiaoxiao Xu +15 more
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Frontiers in Oncology, 2018 Genetic and epigenetic changes in DNA are involved in cancer development and tumor progression. Histone deacetylases (HDACs) are key regulators of gene expression that act as transcriptional repressors by removing acetyl groups from histones.
Amila Suraweera, K. O'Byrne, D. Richard
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