Results 11 to 20 of about 830,895 (193)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma [PDF]

Frontiers in Cell and Developmental Biology, 2020
Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone acetylation caused by deregulated HDAC expression and activity is known to promote tumor progression in
Monica Phimmachanh, Jeremy Z. R. Han, Yolande E. I. O’Donnell, Sharissa L. Latham, Sharissa L. Latham, David R. Croucher, David R. Croucher   +6 more
doaj   +3 more sources

Histone Deacetylase Inhibitors: Synthesis of Tetrapeptide Analogue SAHA/TPX [PDF]

E-Journal of Chemistry, 2011
The inhibition of HDAC (histone deacetylase) activity by specific inhibitors induces growth arrest, differentiation and apoptosis of transformed or several cancer cells. Some of these inhibitors are in clinical trial at phase I or phase II. The discovery
Lynda Ekou, Tchirioua Ekou, Isabelle Opalinski, Jean Pierre Gesson   +3 more
doaj   +2 more sources

Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents

Biologics: Targets & Therapy, 2013
Katherine Ververis,1 Alison Hiong,1 Tom C Karagiannis,1,* Paul V Licciardi2,*1Epigenomic Medicine, Alfred Medical Research and Education Precinct, 2Allergy and Immune Disorders, Murdoch Childrens Research Institute, Melbourne, VIC, Australia*These ...
Ververis K, Hiong A, Karagiannis TC, Licciardi PV   +3 more
doaj   +2 more sources

HDACiDB: a database for histone deacetylase inhibitors

Drug Design, Development and Therapy, 2015
Kasi Murugan,1 Shanmugasamy Sangeetha,2 Shanmugasamy Ranjitha,2 Antony Vimala,2 Saleh Al-Sohaibani,1 Gopal Rameshkumar21Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Bioinformatics Laboratory ...
Murugan K, Sangeetha S, Ranjitha S, Vimala A, Al-Sohaibani S, Rameshkumar G   +5 more
doaj   +1 more source

Histone Deacetylase Inhibitors [PDF]

Journal of Thoracic Oncology, 2011
Histone modification and DNA methylation are critical events that determine gene expression. Histone deacetylases (HDAC) render several critical genes transcriptionally inactive by conferring a “hyperwound” configuration. HDAC inhibition leads to unwinding of the DNA and makes it available to the transcriptional machinery for expression of a number of ...
BRADNER JAMES ELLIOT, MAZITSCHEK RALPH
openaire   +8 more sources

Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]

, 2012
The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Julia Metzner, Metzner, Julia, Nicole Schnur, Manuel Grez, Grez, Manuel, Katryniok, Careen, Careen Katryniok, Bernd L. Sorg, Dieter Steinhilber, Laura Pufahl, Sorg, Bernd Lothar, Pufahl, Laura, Schnur, Nicole, Steinhilber, Dieter   +13 more
core   +1 more source

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model [PDF]

, 2011
NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Disease. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Ezzatizadeh, V, Steve Jones, James R. Rusche, Jones, S, Sandi, C, Joel M. Gottesfeld, Pook, MA, Pinto, RM, Chiranjeevi Sandi, Barnes, G, Mark A. Pook, Al-Mahdawi, S, Vahid Ezzatizadeh, Sahar Al-Mahdawi, Rusche, JR, Ricardo Mouro Pinto, Gottesfeld, JM, Glenn Barnes   +17 more
core   +1 more source

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers

Advanced Biomedical Research, 2019
Epigenetic modifications such as histone modification play an important role in tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key role in cancer induction and progression by histone deacetylation.
Masumeh Sanaei, Fraidoon Kavoosi
doaj   +1 more source

Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]

, 2009
Cigarette smoke (CS)-induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David, Yao, Hongwei, Rahman, Irfan, Seagrave, JeanClare, March, Thomas H   +4 more
core   +1 more source

Immunomodulatory Effects of Histone Deacetylation Inhibitors in Graft-vs.-Host Disease After Allogeneic Stem Cell Transplantation

Frontiers in Immunology, 2021
Histone deacetylase inhibitors are currently the most studied drugs because of their beneficial effects on inflammatory response. Emerging data from numerous basic studies and clinical trials have shown that histone deacetylase inhibitors can suppress ...
Xiaoxiao Xu, Xiaoxiao Xu, Xiaoxiao Xu, Xiaoxiao Xu, Xiaoqin Li, Xiaoqin Li, Xiaoqin Li, Xiaoqin Li, Yanmin Zhao, Yanmin Zhao, Yanmin Zhao, Yanmin Zhao, He Huang, He Huang, He Huang, He Huang   +15 more
doaj   +1 more source