Results 21 to 30 of about 138,704 (292)

Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors

Iraqi Journal of Pharmaceutical Sciences, 2019
Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding ...
Duraid Al-Amily, Mohammed H. Mohammed
doaj   +1 more source

Design, Synthesis, and Docking Study of Acyl Thiourea Derivatives as Possible Histone Deacetylase Inhibitors with a Novel Zinc Binding Group

Scientia Pharmaceutica, 2019
Histone deacetylase inhibitors with zinc binding groups often exhibit drawbacks like non-selectivity or toxic effects. Thus, there are continuous efforts to modify the currently available inhibitors or to discover new derivatives to overcome these ...
Duraid H. Al-Amily, Mohammed Hassan Mohammed   +1 more
doaj   +1 more source

Histone Deacetylase Inhibitors and Phenotypical Transformation of Cancer Cells

Cancers, 2019
Histone deacetylase inhibitors (HDIs) are a group of potent epigenetic drugs which have been investigated for their therapeutic potential in various clinical disorders, including hematological malignancies and solid tumors.
A. Wawruszak, Joanna Kałafut, Estera Okoń, Jakub Czapiński, Marta Halasa, Alicja Przybyszewska, Paulina Miziak, K. Okła, A. Rivero-Muller, A. Stepulak   +9 more
semanticscholar   +1 more source

Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B

Molecular Cancer, 2006
Background In eukaryotic cells, the genomic DNA is packed with histones to form the nucleosome and chromatin structure. Reversible acetylation of the histone tails plays an important role in the control of specific gene expression.
Li Qiao, Bakkar Wafae, Ghazawi Feras M, Chen Jihong   +3 more
doaj   +1 more source

Data for the effect of histone deacetylase inhibitors on voltage- and ligand-gated ion channel gene expression in neurogenic induced-human adipose tissue-derived mesenchymal stem cells

Data in Brief, 2018
This data article contains descriptive and experimental data on ion channel gene expressions following the histone deacetylase (HDAC) inhibitor treatment of neural induced human adipose tissue-derived mesenchymal stem cells (NI-hADSCs).
Sujeong Jang, Han-Seong Jeong
doaj   +1 more source

Next-generation of selective histone deacetylase inhibitors

RSC Advances, 2019
Histone deacetylases (HDACs) are clinically validated epigenetic drug targets for cancer treatment. HDACs inhibitors (HDACis) have been successfully applied against a series of cancers.
Feifei Yang, N. Zhao, Di Ge, Yihua Chen
semanticscholar   +1 more source

Histone Deacetylase Inhibitors from Marine Invertebrates

Biology, 2020
Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing ...
Claudio Luparello, Manuela Mauro, Vincenzo Arizza, Mirella Vazzana   +3 more
doaj   +1 more source

Tau Stabilizes Chromatin Compaction

Frontiers in Cell and Developmental Biology, 2021
An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes remains elusive.
Thomas Rico, Melissa Gilles, Alban Chauderlier, Thomas Comptdaer, Romain Magnez, Maggy Chwastyniak, Herve Drobecq, Florence Pinet, Xavier Thuru, Luc Buée, Marie-Christine Galas, Bruno Lefebvre   +11 more
doaj   +1 more source

Inhibition of capsaicin and dihydrocapsaicin derivatives towards histone deacetylase and molecular docking studies [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2016
The natural products, capsaicin and dihydrocapsaicin, were modified at double-bond and phenolic moieties to provide twelve capsaicin and dihydrocapsaicin derivatives.
Pakit Kumboonma, Thanaset Senawong, Khatcharin Siriwong, Chavi Yenjai, Chanokbhorn Phaosiri   +4 more
doaj  

Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors

Genome Biology, 2019
Histone acetylation plays a central role in gene regulation and is sensitive to the levels of metabolic intermediates. However, predicting the impact of metabolic alterations on acetylation in pathological conditions is a significant challenge.
Fangzhou Shen, Luigi Boccuto, Rini Pauly, Sujata Srikanth, Sriram Chandrasekaran   +4 more
doaj   +1 more source