Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma [PDF]
Frontiers in Cell and Developmental Biology, 2020 Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone acetylation caused by deregulated HDAC expression and activity is known to promote tumor progression in
Monica Phimmachanh +6 more
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Histone deacetylases in stroke
Chinese Journal of Physiology, 2019 Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials ...
Mei-Han Kao, Teng-Nan Lin
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Research Progress on the Mechanism of Histone Deacetylases in Ferroptosis of Glioma [PDF]
Oncology ReviewsGlioma is the most prevalent primary malignant tumor of the central nervous system. While traditional treatment modalities such as surgical resection, radiotherapy, and chemotherapy have made significant advancements in glioma treatment, the prognosis ...
Meng Ma +6 more
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Histone Deacetylases in Retinoblastoma. [PDF]
Int J Mol SciRetinoblastoma, a pediatric ocular malignancy, presents significant challenges in comprehending its molecular underpinnings and targeted therapeutic approaches. The dysregulated activity of histone deacetylases (HDACs) has been associated with retinoblastoma pathogenesis, influencing critical cellular processes like cell cycle regulation or retinal ...
Lisek M +4 more
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Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology [PDF]
BiomoleculesA monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such, provides a semi-selective barrier between the blood and the interstitial space.
Rahul S. Patil +9 more
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Potential of histone deacetylase inhibitors for the therapy of ovarian cancer
Frontiers in Oncology, 2022 Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemotherapy increase patient mortality.
Fengyi Guo, Hongjing Wang, Hongjing Wang
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Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke
Biomedicines, 2021 Cerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4.
Svetlana Demyanenko +2 more
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Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease
Brain Sciences, 2022 Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that is increasingly becoming a global threat to the health and life of the elderly worldwide.
Yan Li +7 more
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Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]
, 2020 Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
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Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. [PDF]
, 2017 SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane ...
Bufalieri, Francesca +18 more
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