Results 11 to 20 of about 360,616 (327)
Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma [PDF]
Frontiers in Cell and Developmental Biology, 2020 Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone acetylation caused by deregulated HDAC expression and activity is known to promote tumor progression in
Monica Phimmachanh +6 more
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Research Progress on the Mechanism of Histone Deacetylases in Ferroptosis of Glioma [PDF]
Oncology ReviewsGlioma is the most prevalent primary malignant tumor of the central nervous system. While traditional treatment modalities such as surgical resection, radiotherapy, and chemotherapy have made significant advancements in glioma treatment, the prognosis ...
Meng Ma +6 more
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Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke
Biomedicines, 2021 Cerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4.
Svetlana Demyanenko +2 more
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Histone deacetylases in stroke
Chinese Journal of Physiology, 2019 Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials ...
Mei-Han Kao, Teng-Nan Lin
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Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy
Cancers, 2020 Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/ deacetylation are the epigenetic mechanisms of the regulation of gene expression and are catalyzed by histone acetyltransferases (HAT) and histone deacetylases (HDAC).
Flavia Alves Verza +2 more
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Genes, 2020 Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here
Giovanni Perini +2 more
exaly +2 more sources
Nature Communications, 2018 Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark ...
Rachel Fellows +25 more
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Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease
Brain Sciences, 2022 Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that is increasingly becoming a global threat to the health and life of the elderly worldwide.
Yan Li +7 more
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Histone deacetylases facilitate the accurate repair of broken forks
Molecular & Cellular Oncology, 2020 We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and ...
Belén Gómez-González +2 more
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Mechanism-based inhibition of zinc-dependent histone deacetylases [PDF]
RSC Chemical BiologyThe hallmark of a mechanism-based inhibitor is a chemical transformation that occurs upon binding in an enzyme active site that typically yields a more potent inhibitory species. A mechanism-based enzyme inhibitor can be a closely-related analogue of the
David W. Christianson
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