Results 11 to 20 of about 51,098 (257)
Inhibition of Histone Deacetylases [PDF]
, 2004 Reversible histone acetylation, governed dynamically by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a pivotal role in regulation of gene expression through remodeling chromatin structure. Manipulation of the equilibrium between acetylation and deacetylation of histones by specific HDAC inhibitors is thus a useful tool to ...
Cheng, Liu, Dawei, Xu
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Histone deacetylases facilitate the accurate repair of broken forks
Molecular & Cellular Oncology, 2020 We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and ...
Belén Gómez-González +2 more
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BMC Plant Biology, 2009 Background Although histone deacetylases from model organisms have been previously identified, there is no clear basis for the classification of histone deacetylases under the RPD3/HDA1 superfamily, particularly on plants.
Yu Chun-Wei +2 more
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Chemical phylogenetics of histone deacetylases [PDF]
Nature Chemical Biology, 2010 The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone deacetylases (HDACs) as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even among compounds widely perceived ...
Bradner, James E. +6 more
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Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis
Pharmaceuticals, 2022 Schistosomiasis is a major neglected parasitic disease that affects more than 240 million people worldwide and for which the control strategy consists of mass treatment with the only available drug, praziquantel.
Ehab Ghazy +4 more
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Haematologica, 2010 Background During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are ...
Peng Ji +4 more
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Histone deacetylase inhibitors
Journal of Education, Health and Sport, 2020 The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence ...
Marzena Baran +2 more
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Haematologica, 2014 Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological ...
Marinus R. Heideman +5 more
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International Journal of Immunopathology and Pharmacology, 2021 Chronic inflammation in asthmatics is initiated/exacerbated by many environmental factors, such as bacterial lipopolysaccharide and allergens. Phospholipase A 2 and histone acetyltransferase/deacetylases are enzymes involved in inflammatory process ...
Ewa Pniewska-Dawidczyk +7 more
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E-Journal of Chemistry, 2011 Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a.
Lynda Ekou +4 more
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