Results 31 to 40 of about 360,616 (327)
Potential of histone deacetylase inhibitors for the therapy of ovarian cancer
Frontiers in Oncology, 2022 Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemotherapy increase patient mortality.
Fengyi Guo, Hongjing Wang, Hongjing Wang
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Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
bioRxiv, 2021 Lysine l-lactylation [K(l-la)] is a newly discovered histone mark that can be stimulated under conditions of high glycolysis, such as the Warburg effect. K(l-la) is associated with functions that are different from the widely studied histone acetylation.
C. Moreno-Yruela +13 more
semanticscholar +1 more source
Targeting histone deacetylases for cancer therapy: Trends and challenges
Acta Pharmaceutica Sinica B, 2023 Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and progression. As promising anticancer targets, HDACs have gained a great deal of research interests and two decades of effort has led to the approval of five HDAC ...
Tao Liang +7 more
semanticscholar +1 more source
Histone deacetylases control lysine acetylation of ribosomal proteins in rice
Nucleic Acids Research, 2021 Lysine acetylation (Kac) is well known to occur in histones for chromatin function and epigenetic regulation. In addition to histones, Kac is also detected in a large number of proteins with diverse biological functions.
Qiutao Xu +6 more
semanticscholar +1 more source
A short guide to histone deacetylases including recent progress on class II enzymes
Experimental and Molecular Medicine, 2020 The interaction between histones and DNA is important for eukaryotic gene expression. A loose interaction caused, for example, by the neutralization of a positive charge on the histone surface by acetylation, induces a less compact chromatin structure ...
Suk-Youl Park, Jeong-Sun Kim
semanticscholar +1 more source
Asian Pacific Journal of Cancer Biology, 2020 Objective: DNA methylation, the covalent addition of a methyl group to cytosine, and histone modification play an important role in the establishment and maintenance of the program of gene expression.
Masumeh Sanaei, Fraidoon Kavoosi
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The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy
Frontiers in Cell and Developmental Biology, 2020 Genetic mutations and abnormal gene regulation are key mechanisms underlying tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores, represent the basic units of chromatin. The fifth amino group (Nε) of histone lysine residues is a
Guo Li, Yuan Tian, Wei-Guo Zhu
semanticscholar +1 more source
Frontiers in Pharmacology, 2020 Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process such ...
S. Shukla, B. Tekwani
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Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer [PDF]
, 2008 Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours.
Dietel Manfred +21 more
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Dissecting the roles of histone deacetylase 1 and 2 in the hematopoietic system [PDF]
, 2008 Reversible histone acetylation on lysine residues has been intensively studied as an epigenetic mark for gene activation in a variety of eukaryotes. Histone deacetylases (HDACs) act to repress gene expression by removing acetyl groups from histones and ...
Yamaguchi, Teppei
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