Results 51 to 60 of about 51,098 (257)
Human neuronal cells: epigenetic aspects
Biomolecular Concepts, 2013 Histone acetyltransferases (HATs) and histone deacetylases (HDACs) promote histone posttranslational modifications, which lead to an epigenetic alteration in gene expression. Aberrant regulation of HATs and HDACs in neuronal cells results in pathological
Kukucka Jessica +4 more
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Journal of Translational Medicine, 2023 NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT).
Siyi Lu +3 more
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Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
In vitro Enzymatic Assays of Histone Decrotonylation on Recombinant Histones
Bio-Protocol, 2018 Class I histone deacetylases (HDACs) are efficient histone decrotonylases, broadening the enzymatic spectrum of these important (epi-)genome regulators and drug targets. Here, we describe an in vitro approach to assaying class I HDACs with different acyl-
Rachel Fellows, Patrick Varga-Weisz
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Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
The role of histone deacetylases in human gastrointestinal and associated glands cancer [PDF]
Journal of Advanced Biomedical Sciences, 2019 Background & Objective: In the eukaryotic cells, the DNA wraps around the histone proteins (H2A, H2B, H3, and H4) and constitutes the nucleosome. Chromatin organization plays a major role in the control of gene expression.
Masumeh Sanaei, Fraidoon Kavoosi
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Nature Communications, 2016 SIRT7 is a member of sirtuin family proteins that are described as NAD+-dependent class III histone deacetylases. Here, the authors show that SIRT7 is histone desuccinylase catalysing H3K122 desuccinylation, thereby promoting chromatin condensation and ...
Lei Li +14 more
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Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
An RNA-seq transcriptome analysis of histone modifiers and RNA silencing genes in soybean during floral initiation process. [PDF]
PLoS ONE, 2013 Epigenetics has been recognised to play vital roles in many plant developmental processes, including floral initiation through the epigenetic regulation of gene expression.
Lim Chee Liew +2 more
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