Results 61 to 70 of about 360,616 (327)
Toxins, 2019 Histone acetylation is an important modification for the regulation of chromatin accessibility and is controlled by two kinds of histone-modifying enzymes: histone acetyltransferases (HATs) and histone deacetylases (HDACs). In filamentous fungi, there is
Xuejie Li, Lijie Pan, Bin Wang, Li Pan
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Histone deacetylases and their inhibitors in inflammatory diseases.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieDespite considerable research efforts, inflammatory diseases remain a heavy burden on human health, causing significant economic losses annually. Histone deacetylases (HDACs) play a significant role in regulating inflammation (via histone and non-histone
Sen-Yu Zhang +4 more
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Beyond Histones: New Substrate Proteins of Lysine Deacetylases in Arabidopsis Nuclei
Frontiers in Plant Science, 2018 The reversible acetylation of lysine residues is catalyzed by the antagonistic action of lysine acetyltransferases and deacetylases, which can be considered as master regulators of their substrate proteins.
Magdalena Füßl +11 more
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Nature Communications, 2021 Current histone microarrays cannot be used to directly study the transient interactions of histone deacetylases (HDACs). Here, the authors show that hydroxamic acid-modified microarrays can capture HDACs, provide insights into their substrate specificity,
Carlos Moreno-Yruela +5 more
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Frontiers in Oncology, 2022 Thyroid cancer is a common malignancy of the endocrine system, with papillary thyroid cancer (PTC) being the most common type of pathology. The incidence of PTC is increasing every year.
Chongyang Chen +2 more
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Chemical genomics reveals histone deacetylases are required for core regulatory transcription
Nature Communications, 2019 Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high interest for cancer treatment.
B. Gryder +14 more
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Acetylation site specificities of lysine deacetylase inhibitors in human cells [PDF]
, 2015 This work was supported by the Hallas Møller Investigator grant from the Novo Nordisk Foundation to C.C. S.A.W. and P.B. were supported by individual postdoctoral grants from the Danish Research Council (FSS: 10-085134, FSS: 12-12610). C.C.
Sebastian A Wagner +40 more
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Biotechnology & Biotechnological Equipment, 2018 Histone deacetylases (HDACs) catalyse the deacetylation of core histones and non-histone proteins. Histone deacetylases work in concert with histone acetyltransferases to modify the structure and function of chromatins, and regulate gene transcription ...
Botong Tong +3 more
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Histone Deacetylases in the Pathogenesis of Diabetic Cardiomyopathy
Frontiers in Endocrinology, 2021 The global burden of diabetes mellitus and its complications are currently increasing. Diabetic cardiomyopathy (DCM) is the main cause of diabetes mellitus associated morbidity and mortality; therefore, a comprehensive understanding of DCM development is
Xiangyu Ke +8 more
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Structure, Mechanism, and Inhibition of the Zinc-Dependent Histone Deacetylases
Current Opinion in Structural Biology, 2019 Zinc-dependent histone deacetylases (HDACs) regulate the biological function of histone and non-histone proteins through the hydrolysis of acetyllysine side chains to yield free lysine and acetate.
N. J. Porter, D. Christianson
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