Results 1 to 10 of about 128,901 (311)
Deacetylation of HSC70 by SIRT2 promotes chaperone mediated autophagy [PDF]
Autophagy ReportsChaperone-mediated autophagy (CMA) is a selective form of lysosomal protein degradation essential for cellular proteostasis. CMA is activated during cellular stress, such as starvation, and involves the chaperone protein HSC70 (HSPA8) recognizing ...
Byunghyun Ahn +5 more
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SIRT2 mediated downregulation of FOXM1 in response to TGFβ through the RAF-MEK-ERK signaling pathway in colon cancer [PDF]
Archives of Biological Sciences, 2021 The transcription factor forkhead box M1 (FOXM1) is frequently upregulated in many solid tumors, including those in the colon. As a master regulator, the sirtuin (SIRT) protein family is comprised of seven nicotinamide adenine dinucleotide (NAD ...
Ozden Ozkan, Park Seong-Hoon
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Extraction and Physicochemical Characterization of Chitosan from Litopenaeus vannamei Shells [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 The chitosan was extracted from a whiteleg shrimp shell (Litopenaeus vannamei (by the deacetylation of chitin, which is carried out using 45% NaOH at 110 ºC for 6 h.
Hengameh Darzi Arbabi +4 more
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New Insight in HDACs: Potential Therapeutic Targets for the Treatment of Atherosclerosis
Frontiers in Pharmacology, 2022 Atherosclerosis (AS) features include progressive hardening and reduced elasticity of arteries. AS is the leading cause of morbidity and mortality. An increasing amount of evidence showed that epigenetic modifications on genes serve are a main cause of ...
Yi Luan +7 more
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Bacterial Sirtuins Overview: An Open Niche to Explore
Frontiers in Microbiology, 2021 Sirtuins are deacetylase enzymes widely distributed in all domains of life. Although for decades they have been related only to histones deacetylation in eukaryotic organisms, today they are considered global regulators in both prokaryotes and eukaryotes.
Julia Gallego-Jara +5 more
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Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]
, 2020 Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
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Hydration mechanism of heterogeneous alkaline deacetylation of chitin [PDF]
Vestnik MGTU, 2017 In the work the hypothesis has been proposed explaining the features of the kinetics of chitin/chitosan alkali deacetylation reaction in highly concentrated solutions of sodium hydroxide, which almost completely stops after 30–60 min after the start of ...
Novikov V. Yu. +4 more
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Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the mechanism of hepatitis B virus X protein down-regulating DKK4 and its effect on the proliferation, migration of HCC cell lines.
ZHANG Wenjing +4 more
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Optimisation of conditions for deacetylation of chitin-containing raw materials
Harčova Nauka ì Tehnologìâ, 2021 The paper describes the differences between chitosan and chitin, and reviews works by foreign scientists on obtaining chitosan from various raw materials. Methods of modifying chitosan and obtaining combined sorbents have been analysed.
O. Pavlova, M. Trusova
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eLife, 2020 The DNA damage response (DDR) is a highly orchestrated process but how double-strand DNA breaks (DSBs) are initially recognized is unclear. Here, we show that polymerized SIRT6 deacetylase recognizes DSBs and potentiates the DDR in human and mouse cells.
Fanbiao Meng +18 more
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