Results 11 to 20 of about 128,901 (311)
Acetylation, Deacetylation and Acyltransfer [PDF]
Environmental Health Perspectives, 1983 N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. Decreasing the levels of metabolites,
C M, King, I B, Glowinski
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Deacetyl tenuazonic acid [PDF]
Acta Crystallographica Section E Structure Reports Online, 2009 The heterocycle in the title compound {systematic name: (5S)-5-[(1S)-1-methylpropyl]pyrrolidine-2,4-dione}, C8H13NO2, is planar (r.m.s. deviation for all non-H atoms = 0.008 Å). The crystal structure is stabilized by N—H...O hydrogen bonding.
David Siegel +3 more
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Deacetylation of Transcription Factors in Carcinogenesis [PDF]
International Journal of Molecular Sciences, 2021 Reversible Nε-lysine acetylation/deacetylation is one of the most common post-translational modifications (PTM) of histones and non-histone proteins that is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). This epigenetic process is highly involved in carcinogenesis, affecting histone and non-histone proteins’ properties
Marta Halasa +6 more
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SIRT1: Regulator of p53 Deacetylation [PDF]
Genes & Cancer, 2013 The cellular NAD(+)/NADH level controls Sir2 (silent information regulator 2) deacetylase activity in regulating aging in lower species. Much work has been put forth to identify ways to activate SIRT1, the mammalian ortholog of Sir2. The identification of p53 as a bona fide substrate of SIRT1 deacetylation has linked SIRT1 to a role in tumorigenesis ...
James T, Lee, Wei, Gu
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Histone epigenetic modifications and their relationship with cancer: a comparative medicine view [PDF]
Ciência Rural, 2023 : Epigenetic modifications have become highly important in the study of cancer pathogenesis due to research showing that changes in the expression of DNA-associated proteins can affect gene expression but may be reversible after treatment.
Igor Luiz Salardani Senhorello +1 more
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Chemical and Mechanical Differences between Historic and Modern Scots Pine Wood
Heritage, 2020 Timber is one of the most common historic building materials, but relatively little is known about how it ages in situ. Here we investigate historic and modern Scots pine to determine any chemical or mechanical differences between them. Fourier-transform
Kate Hudson-McAulay +2 more
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Frontiers in Physiology, 2023 Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
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Frontiers in Microbiology, 2023 Deacetyl-7-aminocephalosporanic acid (D-7-ACA), which could be converted from 7-aminocephalosporanic acid (7-ACA), is a crucial starting material that is used for synthesizing industrial semisynthetic β-lactam antibiotics.
Xiaoliang Wang +7 more
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Sirtuin functions and modulation: from chemistry to the clinic [PDF]
, 2016 Sirtuins are NAD+ -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell ...
Altucci, Lucia +9 more
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Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
Biomolecules, 2021 SIRT1 is the most extensively studied human sirtuin with a broad spectrum of endogenous targets. It has been implicated in the regulation of a myriad of cellular events, such as gene transcription, mitochondria biogenesis, insulin secretion as well as ...
Stacia Rymarchyk, Wenjia Kang, Yana Cen
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