Results 11 to 20 of about 83,086 (267)
Deacetylation of Transcription Factors in Carcinogenesis [PDF]
International Journal of Molecular Sciences, 2021 Reversible Nε-lysine acetylation/deacetylation is one of the most common post-translational modifications (PTM) of histones and non-histone proteins that is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). This epigenetic process is highly involved in carcinogenesis, affecting histone and non-histone proteins’ properties
Marta Halasa +6 more
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Acetylation, Deacetylation and Acyltransfer [PDF]
Environmental Health Perspectives, 1983 N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. Decreasing the levels of metabolites,
C M, King, I B, Glowinski
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Frontiers in Physiology, 2023 Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
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Frontiers in Microbiology, 2023 Deacetyl-7-aminocephalosporanic acid (D-7-ACA), which could be converted from 7-aminocephalosporanic acid (7-ACA), is a crucial starting material that is used for synthesizing industrial semisynthetic β-lactam antibiotics.
Xiaoliang Wang +7 more
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Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
Biomolecules, 2021 SIRT1 is the most extensively studied human sirtuin with a broad spectrum of endogenous targets. It has been implicated in the regulation of a myriad of cellular events, such as gene transcription, mitochondria biogenesis, insulin secretion as well as ...
Stacia Rymarchyk, Wenjia Kang, Yana Cen
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Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression
Cell Reports, 2016 Although previous studies indicate that loss of p53-mediated cell cycle arrest, apoptosis, and senescence does not completely abrogate its tumor suppression function, it is unclear how the remaining activities of p53 are regulated.
Shang-Jui Wang +6 more
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Frontiers in Energy Research, 2019 The National Renewable Energy Laboratory (NREL) developed low severity Deacetylation and Mechanical Refining (DMR) process under atmospheric pressure, generates highly fermentable, low toxicity sugar syrups and highly reactive lignin streams.
Wei Wang +3 more
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SIRT1: Regulator of p53 Deacetylation [PDF]
Genes & Cancer, 2013 The cellular NAD(+)/NADH level controls Sir2 (silent information regulator 2) deacetylase activity in regulating aging in lower species. Much work has been put forth to identify ways to activate SIRT1, the mammalian ortholog of Sir2. The identification of p53 as a bona fide substrate of SIRT1 deacetylation has linked SIRT1 to a role in tumorigenesis ...
James T, Lee, Wei, Gu
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Selective N‐Deacetylation and Functionalization of Aminosugars [PDF]
European Journal of Organic Chemistry, 2022 AbstractN‐Acetyl groups are abundant functional groups found in a variety of biomolecules including aminosugars. N‐Acetyl groups are chemically stable and harsh conditions are often needed to remove them. Herein, we report a mild and efficient protocol to remove N‐acetyl groups in the presence of esters and carbamates and functionalize the resulting ...
Sam J. Moons +2 more
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Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus
Frontiers in Endocrinology, 2021 Diabetes mellitus (DM) has been one of the largest health concerns of the 21st century due to the serious complications associated with the disease. Therefore, it is essential to investigate the pathogenesis of DM and develop novel strategies to reduce ...
Jie Wang(a) +7 more
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