Results 21 to 30 of about 128,901 (311)
Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression
Cell Reports, 2016 Although previous studies indicate that loss of p53-mediated cell cycle arrest, apoptosis, and senescence does not completely abrogate its tumor suppression function, it is unclear how the remaining activities of p53 are regulated.
Shang-Jui Wang +6 more
doaj +1 more source
The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues [PDF]
, 2007 Friedreich ataxia (FRDA) is caused by a homozygous GAA repeat expansion mutation within intron 1 of the FXN gene, leading to reduced expression of frataxin protein.
C. Sandi +7 more
core +1 more source
Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene [PDF]
, 2010 [No abstract ...
CANETTIERI, Gianluca +4 more
core +1 more source
Frontiers in Energy Research, 2019 The National Renewable Energy Laboratory (NREL) developed low severity Deacetylation and Mechanical Refining (DMR) process under atmospheric pressure, generates highly fermentable, low toxicity sugar syrups and highly reactive lignin streams.
Wei Wang +3 more
doaj +1 more source
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability [PDF]
, 2017 R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive regulatory roles but are also a source of genomic instability.
Aguilera López, Andrés +5 more
core +1 more source
Drugs in R & D, 2008 Recent research has elucidated another mechanism for gene expression and signalling protein regulation in malignant cells. Histone deacetylases (HDACs) have been associated with silencing of tumour suppressor genes, and with other functions that promote malignant cell phenotype, such as the function of the chaperone protein heat shock protein (HSP)-90.
Anas, Al-Janadi +2 more
openaire +3 more sources
Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus
Frontiers in Endocrinology, 2021 Diabetes mellitus (DM) has been one of the largest health concerns of the 21st century due to the serious complications associated with the disease. Therefore, it is essential to investigate the pathogenesis of DM and develop novel strategies to reduce ...
Jie Wang(a) +7 more
doaj +1 more source
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells [PDF]
, 2018 Sirtuin 6 (SIRT6) is a member of the NAD+-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy.
Annamaria Biroccio, And +13 more
core +2 more sources
Nicotinamide riboside activates SIRT5 deacetylation
The FEBS Journal, 2023 Human sirtuins play important roles in various cellular events including DNA repair, gene silencing, mitochondrial biogenesis, insulin secretion and apoptosis. They regulate a wide array of protein and enzyme targets through their NAD+‐dependent deacetylase activities. Sirtuins are also thought to mediate the beneficial effects of low‐calorie intake to
Alyson M. Curry +5 more
openaire +2 more sources
Mass Transport Limitations and Kinetic Consequences of Corn Stover Deacetylation
Frontiers in Energy Research, 2022 Alkaline pretreatment of herbaceous feedstocks such as corn stover prior to mechanical refining and enzymatic saccharification improves downstream sugar yields by removing acetyl moieties from hemicellulose.
Nicholas E. Thornburg +12 more
doaj +1 more source