Results 41 to 50 of about 404,910 (338)

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Research progress on histone acetylation/methylation in oral diseases [PDF]

口腔疾病防治
Histone acetylation and methylation can affect chromatin conformation and regulate a variety of biological activities. Abnormal histone acetylation and methylation modifications are related to the occurrence and development of a variety of oral diseases.
LUO Yuchuan, LI Feifei, YU Fanyuan, YIN Bei, YE Ling
doaj   +1 more source

Simvastatin-romidepsin combination kills bladder cancer cells synergistically

Translational Oncology, 2021
The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer
Kazuki Okubo, Kosuke Miyai, Kimi Kato, Takako Asano, Akinori Sato   +4 more
doaj   +1 more source

ALCOHOL METABOLISM CONTRIBUTES TO BRAIN HISTONE ACETYLATION

Nature, 2019
Emerging evidence suggests that epigenetic regulation is dependent on metabolic state, and implicates specific metabolic factors in neural functions that drive behaviour1.
Philipp Mews, Philipp Mews, G. Egervari, Raffaella Nativio, Simone Sidoli, Simone Sidoli, G. Donahue, Sonia I Lombroso, D. Alexander, S. L. Riesche, Elizabeth A. Heller, E. Nestler, Benjamin A. Garcia, S. Berger   +13 more
semanticscholar   +1 more source

Identification of histone acetylation markers in human fetal brains and increased H4K5ac expression in neural tube defects

Molecular Genetics & Genomic Medicine, 2019
Background Neural tube defects (NTDs) are severe common birth defects that result from a failure in neural tube closure (NTC). Our previous study has shown that decreased histone methylation altered the regulation of genes linked to NTC.
Dan Li, Chunlei Wan, Baoling Bai, Haiyan Cao, Changyun Liu, Qin Zhang   +5 more
doaj   +1 more source

Total levels of hippocampal histone acetylation predict normal variability in mouse behavior.

PLoS ONE, 2014
BackgroundGenetic, pharmacological, and environmental interventions that alter total levels of histone acetylation in specific brain regions can modulate behaviors and treatment responses.
Addie May I Nesbitt, Richard D McCurdy, Sharell M Bryant, Mark D Alter   +3 more
doaj   +1 more source

The etiological changes of acetylation in peripheral nerve injury–induced neuropathic hypersensitivity

Molecular Pain, 2018
Neuropathic pain is a common chronic pain condition with mechanisms far clearly been elucidated. Mounting preclinical and clinical studies have shown neuropathic pain is highly associated with histone acetylation modification, which follows expression ...
Xian Wang, Xiaofeng Shen, Yingli Xu, Shiqin Xu, Fan Xia, Bei Zhu, Yusheng Liu, Wei Wang, Haibo Wu, Fuzhou Wang   +9 more
doaj   +1 more source

Regulation of transcription by the Arabidopsis UVR8 photoreceptor involves a specific histone modification [PDF]

, 2016
The photoreceptor UV RESISTANCE LOCUS 8 (UVR8) specifically mediates photomorphogenic responses to UV-B wavelengths. UVR8 acts by regulating transcription of a set of genes, but the underlying mechanisms are unknown. Previous research indicated that UVR8
Herzyk, Pawel, Jenkins, Gareth I., Velanis, Christos N.   +2 more
core   +1 more source

Histone acetylation increases chromatin accessibility [PDF]

Journal of Cell Science, 2005
In eukaryotes, the interaction of DNA with proteins and supramolecular complexes involved in gene expression is controlled by the dynamic organization of chromatin inasmuch as it defines the DNA accessibility. Here, the nuclear distribution of microinjected fluorescein-labeled dextrans of 42 kDa to 2.5 MDa molecular mass was used to characterize the ...
Görisch, Sabine M., Wachsmuth, Malte, Fejes Tóth, Katalin, Lichter, Peter, Rippe, Karsten   +4 more
openaire   +3 more sources

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection. [PDF]

, 2017
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Alland, Aung, Azad, Bannister, Barchowsky, Bell, Bird, Brilha, Chen, Chernov, Choudhary, Culley, de Ruijter, Dobaczewski, Elkington, Feng, Goldberg, Green, Gregoire, Gregoretti, Horiuchi, Jaspers, Khan, Kim, Kleinsteuber, Kubler, Kumar, Lee, Loffek, Lu, Maciejewska-Rodrigues, Majeed, McErlean, McGarry Houghton, Michael, Mittelstadt, Mortaz, Moser, Nasu, Omanakuttan, Ong, Ong, Roger, Shahbazian, Shammari, Singh, Swamy, Tezera, Thuong, Wallis, Wang, Wang, Wolffe   +52 more
core   +2 more sources