Results 51 to 60 of about 404,910 (338)

Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites

Molecular Metabolism
Objectives: Histone acetylation is an important epigenetic modification that regulates various biological processes and cell homeostasis. Acetyl-CoA, a hub molecule of metabolism, is the substrate for histone acetylation, thus linking metabolism with ...
Anna-Sophia Egger, Eva Rauch, Suraj Sharma, Tobias Kipura, Madlen Hotze, Thomas Mair, Alina Hohenegg, Philipp Kobler, Ines Heiland, Marcel Kwiatkowski   +9 more
doaj   +1 more source

Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]

, 2012
Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
core   +1 more source

Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling [PDF]

, 2008
In the plant pathogen Phytophthora infestans, nuclear integration of inf1 transgenic DNA sequences results in internuclear gene silencing of inf1. Although silencing is regulated at the transcriptional level, it also affects transcription from other ...
Appiah, A.A., Govers, F., Gow, N.A.R., Grenville-Briggs, L., Li, S., Shepherd, S.J., Walker, C.A., West, P., van   +7 more
core   +3 more sources

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model

Acta Neuropathologica Communications, 2019
Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many models of neurodegeneration, global histone acetylation is decreased in the affected neuronal ...
E. Rossaert, Eveliina Pollari, T. Jaspers, Lawrence Van Helleputte, M. Jarpe, P. van Damme, Katrien de Bock, M. Moisse, L. Van Den Bosch   +8 more
semanticscholar   +1 more source

Assessment of global histone acetylation in pediatric and adolescent obesity: Correlations with SIRT1 expression and metabolic-inflammatory profiles.

PLoS ONE, 2023
BackgroundEpigenetic modifications, particularly histone acetylation-deacetylation and its related enzymes, such as sirtuin 1 (SIRT1) deacetylase, may have substantial roles in the pathogenesis of obesity and its associated health issues.
Nima Taghizadeh, Soha Mohammadi, Zeynab Yousefi, Pegah Golpour, Alemeh Taheri, Mohammad Hasan Maleki, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy Azar   +8 more
doaj   +1 more source

Histone acetylation in drug addiction [PDF]

Seminars in Cell & Developmental Biology, 2009
Regulation of chromatin structure through post-translational modifications of histones (e.g., acetylation) has emerged as an important mechanism to translate a variety of environmental stimuli, including drugs of abuse, into specific changes in gene expression.
William, Renthal, Eric J, Nestler
openaire   +2 more sources

Displacement of Histones at Promoters of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e Heat Shock Genes Is Differentially Associated with Histone H3 Acetylation [PDF]

, 2006
Chromatin remodeling at promoters of activated genes spans from mild histone modifications to outright displacement of nucleosomes in trans. Factors affecting these events are not always clear.
Erkina, Tamara Y., Erkine, Alexander M.
core   +1 more source

Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]

, 2018
Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core   +1 more source

Wheat microbiome bacteria can reduce virulence of a plant pathogenic fungus by altering histone acetylation

Nature Communications, 2018
Interactions between bacteria and fungi have great environmental, medical, and agricultural importance, but the molecular mechanisms are largely unknown.
Yun Chen, Jing Wang, N. Yang, Ziyue Wen, Xuepeng Sun, Yunrong Chai, Zhonghua Ma   +6 more
semanticscholar   +1 more source

Progress of Acetylation Modification in Plants

Agronomy
Protein acetylation, a conserved post-translational modification, is collaboratively catalyzed by acetyltransferases and deacetylases and is widespread in plants.
Ruiqi Li, Xuezhong Li, Ying He, Xiaoyuan Chen, Jing Li, Chuxiong Zhuang   +5 more
doaj   +1 more source