Results 61 to 70 of about 404,910 (338)

NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.

PLoS ONE, 2011
BackgroundNuclear factor (NF)-κB inducing kinase (NIK) is a central player in the non-canonical NF κB pathway, which phosphorylates IκB kinase α (IKKα) resulting in enhancement of target gene expression.
Sangwoon Chung, Isaac K Sundar, Jae-Woong Hwang, Fiona E Yull, Timothy S Blackwell, Vuokko L Kinnula, Michael Bulger, Hongwei Yao, Irfan Rahman   +8 more
doaj   +1 more source

Histone regulator KAT2A acts as a potential biomarker related to tumor microenvironment and prognosis of diffuse large B cell lymphoma

BMC Cancer, 2023
Background Recent studies have indicated that epigenetic alterations contribute significantly to lymphoma pathogenesis. A type of epigenetic regulation known as histone acetylation plays a crucial role in transcriptional regulation in eukaryotic cells ...
Zhuoya Yu, Mengfei Ding, Yiqing Cai, Tiange Lu, Xiaomin Chen, Xiangxiang Zhou, Xin Wang   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma [PDF]

, 2019
BACKGROUND: Treatment for Cutaneous T Cell Lymphoma (CTCL) is generally not curative. Therefore, selecting therapy that is effective and tolerable is critical to clinical decision-making. Histone deacetylase inhibitors (HDACi), epigenetic modifier drugs,
Andrews, Jared M, Carson, Kenneth R, Mehta-Shah, Neha, Musiek, Amy C, Payton, Jacqueline E, Schmidt, Jennifer A   +5 more
core   +2 more sources

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Histone Acetylation Promotes Neutrophil Extracellular Trap Formation

Biomolecules, 2019
Neutrophils undergo a unique form of cell death to generate neutrophil extracellular traps (NETs). It is well established that citrullination of histones (e.g., CitH3) facilitates chromatin decondensation during NET formation (NETosis), particularly ...
Hussein J Hamam, M. Khan, N. Palaniyar
semanticscholar   +1 more source

Failure of long-term memory formation in juvenile snails is determined by acetylation status of histone H3 and can be improved by NaB treatment. [PDF]

PLoS ONE, 2012
BACKGROUND: Animals' capacities for different forms of learning do not mature simultaneously during ontogenesis but the molecular mechanisms behind the delayed development of specific types of memory are not fully understood.
Alexandra B Danilova, Larisa N Grinkevich   +1 more
doaj   +1 more source

Histone H3 Acetylation Is Involved in Retinoid Acid-Induced Neural Differentiation through Increasing Mitochondrial Function

Biomedicines, 2023
Histone acetylation and mitochondrial function contribute importantly to neural differentiation, which is critically associated with neurodevelopmental disorders such as Down Syndrome (DS).
Yang Zhang, Xinjuan Wang, Qing Mu, Xueyu Hou, Weidong Yu, Jingzhu Guo   +5 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]

, 2012
The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Grez, Manuel, Katryniok, Careen, Metzner, Julia, Pufahl, Laura, Schnur, Nicole, Sorg, Bernd Lothar, Steinhilber, Dieter   +6 more
core   +1 more source