Results 1 to 10 of about 118,012 (240)

Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection [PDF]

Molecules, 2017
Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both compounds may contribute to various pathological conditions.
Joanne Clark-Matott, Elena P Isakova, M Flint Beal   +2 more
exaly   +4 more sources

Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery [PDF]

International Journal of Molecular Sciences, 2020
Small biomolecules, such as coenzyme A (CoA) and acetyl coenzyme A (acetyl-CoA), play vital roles in the regulation of cellular energy metabolism.
Yevgeniya I Shurubor, Arthur J L Cooper, Elena P Isakova   +2 more
exaly   +3 more sources

Acetyl Coenzyme A: A Central Metabolite and Second Messenger [PDF]

Cell Metabolism, 2015
Acetyl-coenzyme A (acetyl-CoA) is a central metabolic intermediate. The abundance of acetyl-CoA in distinct subcellular compartments reflects the general energetic state of the cell.
Federico Pietrocola, Lorenzo Galluzzi, JOSÉ Manuel Bravo-San Pedro   +2 more
exaly   +4 more sources

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. [PDF]

Cell Chem Biol, 2022
We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978) selects for ...
Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, Rubiano K, Akidil A, Ottilie S, Mittal N, Dilmore AH, Won M, Mandt REK, McGowen K, Owen E, Walpole C, Llinás M, Lee MCS, Winzeler EA, Fidock DA, Gilbert IH, Wirth DF, Niles JC, Baragaña B, Lukens AK.   +33 more
europepmc   +3 more sources

Capillary electrophoretic assay of human acetyl‐coenzyme A carboxylase 2

Electrophoresis, 2019
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Human acetyl-coenzyme A carboxylase 2 catalyzes the carboxylation of acetyl coenzyme A to form malonyl coenzyme A, along with the conversion of magnesium-adenosine triphosphate complex to magnesium ...
Grover L Waldrop, S Douglass Gilman
exaly   +2 more sources

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A [PDF]

Molecular Cell, 2014
Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid depletion of AcCoA.
Fernández AF, Eisenberg T, López Otín C, MAIURI, MARIA CHIARA, Andersen JS, Scoazec M, Hill JA, Schroeder S, Niso Santano M, Durand S, Andryushkova A, Kroemer G., Bauvy C, Zamzami N, Kepp O, Magnes C, Mariño G, Vacchelli E, Codogno P, Harger A, Pietrocola F, Enot DP, Sinner F, Pieber T, Malik SA, Madeo F, Bennetzen M, Martins I, Pendl T, Kong Y, Senovilla L, Morselli E   +31 more
core   +5 more sources

Extending the Scope of ¹H NMR Spectroscopy for the Analysis of Cellular Coenzyme A and Acetyl Coenzyme A. [PDF]

Anal Chem, 2019
Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) are ubiquitous cellular molecules, which mediate hundreds of anabolic and catabolic reactions including energy metabolism.
Nagana Gowda GA, Abell L, Tian R.
europepmc   +2 more sources

Synthetic biology for engineering acetyl coenzyme A metabolism in yeast. [PDF]

mBio, 2014
The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels, chemicals, and pharmaceuticals. The use of this cell factory for cost-efficient production of novel fuels and chemicals requires high yields and low by-product ...
Nielsen J.
europepmc   +2 more sources

Mixed Valence {Ni²⁺Ni¹⁺} Clusters as Models of Acetyl Coenzyme A Synthase Intermediates. [PDF]

J Am Chem Soc
Acetyl coenzyme A synthase (ACS) catalyzes the formation and deconstruction of the key biological metabolite, acetyl coenzyme A (acetyl-CoA). The active site of ACS features a {NiNi} cluster bridged to a [Fe 4S 4] n+ cubane known as the A-cluster.
Wilson DWN, Thompson BC, Collauto A, Hooper RX, Knapp CE, Roessler MM, Musgrave RA.   +6 more
europepmc   +2 more sources

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A [PDF]

Cell Metabolism, 2019
Sung Min Son, So Jung Park, Huikyong Lee   +2 more
exaly   +2 more sources