Results 31 to 40 of about 118,012 (240)

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Response of an Infant With Presumed Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) to Ketone Supplementation

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive inborn error of metabolism caused by biallelic pathogenic variants in one of three known genes: ETFA, ETFB, and ETFDH. It can cause multisystem dysfunction, including cardiomyopathy in severe cases.
Yutaka Furuta, Kaitlyn N. Bloom, Jerry Vockley, Angela R. Grochowsky, Neena S. Agrawal, Ellen W. Strickler, Natalie N. Owen, Erica T. Gray, B. Lakshitha A. Perera, Eric R. Gamazon, Lynette C. Rives, Hua‐Chang Chen, Qi Liu, Rizwan Hamid, Joy D. Cogan, John A. Phillips III, Thomas A. Cassini, Bryce A. Schuler   +17 more
wiley   +1 more source

An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis

, 2012
Synthesis of acetate from carbon dioxide and molecular hydrogen is considered to be the first carbon assimilation pathway on earth. It combines carbon dioxide fixation into acetyl-CoA with the production of ATP via an energized cell membrane.
Kaster, Anne-Kristin, Meike Goenrich, Gerhard Gottschalk, Schmidt, Silke, Volker Müller, Hecker, M., Schmidt, S., John Vollmers, Silke Schmidt (46446), Anja Poehlein, Andrea Thürmer, Gerhard Gottschalk (34564), Vollmers, John, Thauer, R., Thurmer, A., Goenrich, Meike, Schuchmann, Kai, Michael Hecker, Meike Goenrich (174838), Thauer, Rudolf K., Rudolf K. Thauer (174856), Volker Müller (49251), Gottschalk, G., Hecker, Michael, Müller, Volker, Gottschalk, Gerhard, Bertsch, J., Daniel, R., Muller, V., Silke Schmidt, Birgit Voigt (174853), Poehlein, Anja, Schuchmann, K., Goenrich, M., Rudolf K Thauer, Andrea Thürmer (174844), Johannes Bertsch, Anne-Kristin Kaster (174829), Rolf Daniel (113374), Bertsch, Johannes, Johannes Bertsch (174847), Vollmers, J., Birgit Voigt, Kai Schuchmann (174850), Thürmer, Andrea, John Vollmers (174842), Rolf Daniel, Daniel, Rolf, Kaster, A., Anne-Kristin Kaster, Voigt, Birgit, Kai Schuchmann, Anja Poehlein (113372), Michael Hecker (51971), Voigt, B., Poehlein, A.   +55 more
core   +1 more source

Resistance to spiromesifen in Trialeurodes vaporariorum is associated with a single amino acid replacement in its target enzyme acetyl-coenzyme A carboxylase

, 2012
Spiromesifen is a novel insecticide and is classed as a tetronic acid derivative. It targets the insects' acetyl-coenzyme A carboxylase (ACCase) enzyme, causing a reduction in lipid biosynthesis.
Denholm, I., Karatolos, N., Gorman, K., Ffrench-Constant, R. H., Nauen, R., Williamson, M. S.   +5 more
core   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

, 2019
Malaria eradication is critically dependent on new therapeutics that target resistant; Plasmodium; parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage; Plasmodium falciparum ...
Vos, Martijn W., Jackowski, Suzanne, Trevitt, Graham, Kooij, Taco W. A., de Vries, Laura E., Dechering, Koen J., Rutjes, Floris P. J. T., Verhoef, Julie M.J., Rutjes, Floris P.J.T., Koolen, Karin M. J., Miller, Karen, Hermkens, Pedro H. H., Botman, Peter N. M., Verhoef, Julie M. J., Koolen, Karin M.J., Botman, Peter N.M., Scheurer, Christian, Fischli, Christoph, Reeves, Stacy A., Wittlin, Sergio, Pett, Helmi, Blaauw, Richard H., Angulo-Barturen, Iñigo, Josling, Gabrielle, Beuckens-Schortinghuis, Christien A., Jansen, Patrick A.M., Jansen, Patrick A. M., Llinás, Manuel, Schalkwijk, Joost, Allman, Erik L., Jiménez-Diaz, Mariá Belén, Campo, Brice, Sauerwein, Robert W., Kooij, Taco W.A., Bonnert, Roger, Bolscher, Judith M., Sax, Sibylle, Hermkens, Pedro H.H.   +37 more
core   +1 more source

Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT To advance understanding of cellular metabolism and reduce batch‐to‐batch variability in cell culture processes, this study introduces a multi‐scale hybrid modeling framework designed to simulate and predict the dynamic behavior of CHO cell cultures undergoing metabolic phase transitions.
Keqi Wang, Sarah W. Harcum, Wei Xie
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source