A capillary electrophoretic assay for acetyl coenzyme A carboxylase [PDF]
Analytical Biochemistry, 2013 A simple off-column capillary electrophoretic (CE) assay for measuring acetyl coenzyme A carboxylase holoenzyme (holo-ACC) activity and inhibition was developed. The two reactions catalyzed by the holo-ACC components, biotin carboxylase (BC) and carboxyltransferase (CT), were simultaneously monitored in this assay. Acetyl coenzyme A (CoA), malonyl-CoA,
Grover L Waldrop, S Douglass Gilman
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Regulation of
mSphere, 2018 To satisfy its fatty acid needs, the extracellular eukaryotic parasite Trypanosoma brucei relies on two mechanisms: uptake of fatty acids from the host and de novo synthesis. We hypothesized that T.
Sunayan S. Ray +2 more
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Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models [PDF]
Emerging Microbes and Infections, 2019 Flaviviruses are (re)-emerging RNA viruses strictly dependent on lipid metabolism for infection. In the search for host targeting antivirals, we explored the effect of pharmacological modulation of fatty acid metabolism during flavivirus infection ...
Nereida Jiménez de Oya +15 more
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Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model [PDF]
Hepatology Communications, 2020 A promising approach for the treatment of nonalcoholic steatohepatitis (NASH) is the inhibition of enhanced hepatic de novo lipogenesis (DNL), which is the synthesis of fatty acids from nonlipid sources.
Berangere Gapp +15 more
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Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan +13 more
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Correlation of acetyl‐coenzyme A carboxylase 1 with Th17 and Th1 cells, serving as a potential prognostic biomarker for acute ischemic stroke patients [PDF]
Journal of Clinical Laboratory Analysis, 2022 Jingjing Jiang, Linlin Li, Shurui Li
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Regulation of Acetyl-Coenzyme A Carboxylase and Acetyl-Coenzyme A Synthetase in Spinach Chloroplasts
Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 1984 In analogy to chloroplast fatty acid synthesis from acetate the key enzymes of acetate fixation, acetyl-CoA synthetase and acetyl-CoA carboxylase, in rapidly Triton X-100 lysed spinach chloroplasts show an activation by light and deactivation in the dark. The stim ulation of acetyl-CoA carboxylase by dithiothreitol in darkened chloroplasts points to an
Klaus-Peter Heise
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How Experimental Adjustments and Optimizations led to Success in obtaining Enzyme-Ligand Crystal Structures of Zymoseptoria tritici ACCase Carboxyltransferase domain [PDF]
Structural DynamicsZymoseptoria tritici (Z. tritici) is a wheat pathogen that causes septoria leaf blotch, and it is one of the most economically damaging diseases of wheat.
Timothy J. Rydel +7 more
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Legume Cytosolic and Plastid Acetyl-Coenzyme—A Carboxylase Genes Differ by Evolutionary Patterns and Selection Pressure Schemes Acting before and after Whole-Genome Duplications [PDF]
Genes, 2018 Michał Ksiazkiewicz +2 more
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Activation of spinach chloroplast acetyl-coenzyme A carboxylase by coenzyme A [PDF]
FEBS Letters, 1982 William A Laing
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