Molecular basis and functional characterization of human 3-methylcrotonyl-CoA carboxylase deficiency [PDF]
, 2009 3-Methylcrotonyl-CoA carboxylase (MCC) deficiency is a rare disorder of leucine catabolism inherited as an autosomal recessive trait. The phenotypic expression of the disease is highly variable, ranging from neonatal onset with severe neurological ...
Dantas, Maria Fernanda
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Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease [PDF]
, 2006 Includes bibliographical references (leaves 130-173).Metabolic remodeling is thought to be an important contributor towards the development of various cardiac pathophysiologic conditions.
Makaula, Siyanda S S
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Cell Reports, 2023 Summary: Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
Huanyi Cao +12 more
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Huddling alleviates the decrease in glycogen and lipid content in the liver of Brandt’s vole caused by mild cold environment [PDF]
Zoologia (Curitiba)Low/cold ambient temperatures can induce hepatic damage in mammals, prompting the evolution of huddling as an adaptive strategy among small mammals to survive cold conditions in the wild.
Jin-Hui Xu +6 more
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Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cellss⃞
Journal of Lipid Research, 2007 Black tea is one of the world's most popular beverages, and its health-promoting effects have been intensively investigated. The antiobesity and hypolipidemic effects of black tea have attracted increasing interest, but the mechanisms underlying these ...
Chih-Li Lin +2 more
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Mitochondrial fatty acid beta-oxidation
EXCLI Journal : Experimental and Clinical SciencesPeripheral artery disease (PAD) is an atherosclerotic disease impacting over 200 million individuals and the prevalence increases with age. PAD occurs when plaque builds up within the peripheral arteries, leading to reduced blood flow and oxygen supply ...
Cassandra E. Bradley +7 more
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Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells
Journal of Lipid Research, 2007 Glial cells play a pivotal role in brain fatty acid metabolism and membrane biogenesis. However, the potential regulation of lipogenesis and cholesterologenesis by fatty acids in glial cells has been barely investigated.
Francesco Natali +3 more
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Characterization of flagellin perception in "Arabidopsis thaliana" [PDF]
, 2003 At the time when this work was started, a highly sensitive perception system for bacterial flagellin in plant cells had been described (Felix et al, 1999), and FLS1 and FLS2, had been identified in A.
Bauer, Zsuzsa
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Elevating acetyl-CoA levels reduces aspects of brain aging
eLife, 2019 Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121
Antonio Currais +8 more
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Mechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects. [PDF]
Endocrinol Diabetes MetabThe primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Andevari AN, Koolivand M.
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