Results 31 to 40 of about 13,638 (176)

Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells

Journal of Lipid Research, 2007
Glial cells play a pivotal role in brain fatty acid metabolism and membrane biogenesis. However, the potential regulation of lipogenesis and cholesterologenesis by fatty acids in glial cells has been barely investigated.
Francesco Natali, Luisa Siculella, Serafina Salvati, Gabriele V. Gnoni   +3 more
doaj   +1 more source

Mitochondrial fatty acid beta-oxidation

EXCLI Journal : Experimental and Clinical Sciences
Peripheral artery disease (PAD) is an atherosclerotic disease impacting over 200 million individuals and the prevalence increases with age. PAD occurs when plaque builds up within the peripheral arteries, leading to reduced blood flow and oxygen supply ...
Cassandra E. Bradley, Emma Fletcher, Trevor Wilkinson, Andrew Ring, Lucas Cardona Ferrer, Dimitrios Miserlis, Pal Pacher, Panagiotis Koutakis   +7 more
doaj   +1 more source

Elevating acetyl-CoA levels reduces aspects of brain aging

eLife, 2019
Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121
Antonio Currais, Ling Huang, Joshua Goldberg, Michael Petrascheck, Gamze Ates, António Pinto-Duarte, Maxim N Shokhirev, David Schubert, Pamela Maher   +8 more
doaj   +1 more source

Structure and Expression of an Arabidopsis Acetyl-Coenzyme A Carboxylase Gene [PDF]

Plant Physiology, 1994
Acetyl-coenzyme A carboxylase (ACCase) catalyzes the formation of malonyl-coenzyme A, which is used in the plastid for fatty acid synthesis and in the cytosol for several pathways including fatty acid elongation and flavonoid synthesis. Two overlapping Arabidopsis genomic clones were isolated and sequenced to determine the entire ACCase-coding region ...
K R, Roesler, B S, Shorrosh, J B, Ohlrogge   +2 more
openaire   +2 more sources

Alleles contributing to acetyl coenzyme A carboxylase (ACCase) resistance in keng stiffgrass (Pseudosclerochloa kengiana) populations from China

Journal of Integrative Agriculture, 2017
Keng stiffgrass is a grass weed that affects wheat-rice cropping systems in China. The extensive reliance on acetyl coenzyme A carboxylase (ACCase)-inhibiting herbicides has resulted in keng stiffgrass developing resistance to these herbicides.
Guo-hui YUAN, Wen-lei GUO, Long DU, Wei-tang LIU, Qi LI, Ling-xu LI, Jin-xin WANG   +6 more
doaj   +1 more source

Proteolysis of liver acetyl coenzyme A carboxylase by cathepsin B [PDF]

FEBS Letters, 1985
Proteolysis of acetyl‐CoA carboxylase was examined with cathepsin B. When chicken liver acetyl‐CoA carboxylase was incubated with cathepsin B at pH 6.3, the native 220‐kDa polypeptide was primarily cleaved into two polypeptides of 125 and 115 kDa, and further degraded to polypeptides of 100–50 kDa.
Wada, Kenji, Tanabe, Tadashi
openaire   +2 more sources

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata

Biomolecules, 2019
In addition to being essential for the transcription of genes involved in cellular lipogenesis, increasing evidence associates sterol regulatory element binding proteins (SREBPs) with the transcriptional control of carbohydrate metabolism.
Jonás I. Silva-Marrero, Juliana Villasante, Ania Rashidpour, Mariana Palma, Anna Fàbregas, María Pilar Almajano, Ivan Viegas, John G. Jones, Montserrat Miñarro, Josep R. Ticó, Isabel V. Baanante, Isidoro Metón   +11 more
doaj   +1 more source

Indole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet

Natural Products and Bioprospecting, 2022
Alstonia scholaris (L.) R. Br (Apocynaceae) is a well-documented medicinal plant for treating respiratory diseases, liver diseases and diabetes traditionally.
Shui-Fen Sun, Hui-Jie Zhong, Yun-Li Zhao, Xiu-Ying Ma, Jin-Bo Luo, Ling Zhu, Yu-Ting Zhang, Wen-Xue Wang, Xiao-Dong Luo, Jia-Wei Geng   +9 more
doaj   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source