Results 51 to 60 of about 13,638 (176)

Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs

Journal of Clinical Laboratory Analysis, EarlyView.
Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo, Zun Wang, Guangzhi Ma, Wang Shen, Xiaobo Chen, Yida Liao   +5 more
wiley   +1 more source

Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins

Journal of Lipid Research, 1997
The sterol regulatory element binding proteins (SREBPs) are central regulators of lipid homeostasis in mammalian cells. Their activity is controlled by a sterol-regulated two-step proteolytic process that releases the nuclear targeted amino-terminal ...
M M Magaña, S S Lin, K A Dooley, T F Osborne   +3 more
doaj   +1 more source

Stimulation of hepatic lipogenesis and acetyl-coenzyme A carboxylase by vasopressin [PDF]

Biochemical Journal, 1981
The effect of vasopressin on the short-term regulation of fatty acid synthesis was studied in isolated hepatocytes from rats fed ad libitum. Vasopressin stimulates fatty acid synthesis by 30-110%. This increase is comparable with that obtained with insulin. Angiotensin also stimulates fatty acid synthesis, whereas phenylephrine does not.
F, Assimacopoulos-Jeannet, R M, Denton, B, Jeanrenaud   +2 more
openaire   +2 more sources

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Effects of Kisspeptin-10 on Lipid Metabolism in Cultured Chicken Hepatocytes [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
Our previous studies showed that kisspeptin-10 (Kp-10) injected in vivo can markedly increase lipid anabolism in liver of quails. In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from ...
J. Wu, W. Fu, Y. Huang, Y. Ni
doaj   +1 more source

“Hard Core” Acetyl Coenzyme‐A Carboxylase

The FASEB Journal, 2015
Diseases involving unregulated cell reproduction, (i.e. cancer) can be inhibited through acetyl coenzyme‐A carboxylase (ACC) manipulation, preventing the lipid production that is imperative for cell survival. ACC catalyzes the first step in the fatty acid biosynthesis. ACC contains two dimers, biotin carboxylase (BC) and carboxyltransferase (CT), and a
Chris Elniff, Dayana Bernardi, Nina Boonyasiti, Ahadou Derib‐Adugna, Alana Einspahr, Sahiba Grover, Namratha Kandru, Nathan Lux, Sai Marre, Jansher Dhillon, Kyra Duong, Herra Hameedi, Julissa Razo, Laura Fogt, Aron Fenton   +14 more
openaire   +1 more source

Insulin and the regulation of adipose-tissue acetyl-coenzyme A carboxylase [PDF]

Biochemical Journal, 1973
Rat epididymal fat-pads were incubated for 30min with glucose (2mg/ml) in the presence or absence of insulin. A twofold or greater increase in acetyl-CoA carboxylase activity was observed in extracts from insulin-treated tissue provided that assays were performed rapidly after extraction.
A P, Halestrap, R M, Denton
openaire   +2 more sources

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. [PDF]

PLoS Genetics, 2010
It has been suggested that genetic susceptibility plays an important role in the pathogenesis of diabetic nephropathy. A large-scale genotyping analysis of gene-based single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes ...
Shiro Maeda, Masa-aki Kobayashi, Shin-ichi Araki, Tetsuya Babazono, Barry I Freedman, Meredith A Bostrom, Jessica N Cooke, Masao Toyoda, Tomoya Umezono, Lise Tarnow, Torben Hansen, Peter Gaede, Anders Jorsal, Daniel P K Ng, Minoru Ikeda, Toru Yanagimoto, Tatsuhiko Tsunoda, Hiroyuki Unoki, Koichi Kawai, Masahito Imanishi, Daisuke Suzuki, Hyoung Doo Shin, Kyong Soo Park, Atsunori Kashiwagi, Yasuhiko Iwamoto, Kohei Kaku, Ryuzo Kawamori, Hans-Henrik Parving, Donald W Bowden, Oluf Pedersen, Yusuke Nakamura   +30 more
doaj   +1 more source

Acetyl‐coenzyme A carboxylases: Versatile targets for drug discovery [PDF]

Journal of Cellular Biochemistry, 2006
AbstractAcetyl‐coenzyme A carboxylases (ACCs) have crucial roles in fatty acid metabolism in humans and most other living organisms. They are attractive targets for drug discovery against a variety of human diseases, including diabetes, obesity, cancer, and microbial infections.
Liang, Tong, H James, Harwood
openaire   +2 more sources