Results 61 to 70 of about 113,959,850 (208)

Acetyl‐coenzyme A carboxylases: Versatile targets for drug discovery [PDF]

Journal of Cellular Biochemistry, 2006
AbstractAcetyl‐coenzyme A carboxylases (ACCs) have crucial roles in fatty acid metabolism in humans and most other living organisms. They are attractive targets for drug discovery against a variety of human diseases, including diabetes, obesity, cancer, and microbial infections.
Liang, Tong, H James, Harwood
openaire   +2 more sources

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, EarlyView.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins

Journal of Lipid Research, 1997
The sterol regulatory element binding proteins (SREBPs) are central regulators of lipid homeostasis in mammalian cells. Their activity is controlled by a sterol-regulated two-step proteolytic process that releases the nuclear targeted amino-terminal ...
M M Magaña, S S Lin, K A Dooley, T F Osborne   +3 more
doaj   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source

Fitness costs associated with evolved herbicide resistance alleles in plants [PDF]

, 2009
Predictions based on evolutionary theory suggest that the adaptive value of evolved herbicide resistance alleles may be compromised by the existence of fitness costs.
Martin M. Vila‐Aiub, Powles, Stephen B., Stephen B. Powles, Vila-Aiub, Martin M., Neve, Paul, Paul Neve   +5 more
core   +1 more source

How Experimental Adjustments and Optimizations led to Success in obtaining Enzyme-Ligand Crystal Structures of Zymoseptoria tritici ACCase Carboxyltransferase domain [PDF]

Structural Dynamics
Zymoseptoria tritici (Z. tritici) is a wheat pathogen that causes septoria leaf blotch, and it is one of the most economically damaging diseases of wheat.
Timothy J. Rydel, Rachappa Balkunde, Timothy Boyle, Rong Ma, Paramita Deria, Michael Crawford, Virginie Lempereur, Tommi White   +7 more
doaj   +1 more source

Effects of Kisspeptin-10 on Lipid Metabolism in Cultured Chicken Hepatocytes [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
Our previous studies showed that kisspeptin-10 (Kp-10) injected in vivo can markedly increase lipid anabolism in liver of quails. In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from ...
J. Wu, W. Fu, Y. Huang, Y. Ni
doaj   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. [PDF]

PLoS Genetics, 2010
It has been suggested that genetic susceptibility plays an important role in the pathogenesis of diabetic nephropathy. A large-scale genotyping analysis of gene-based single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes ...
Shiro Maeda, Masa-aki Kobayashi, Shin-ichi Araki, Tetsuya Babazono, Barry I Freedman, Meredith A Bostrom, Jessica N Cooke, Masao Toyoda, Tomoya Umezono, Lise Tarnow, Torben Hansen, Peter Gaede, Anders Jorsal, Daniel P K Ng, Minoru Ikeda, Toru Yanagimoto, Tatsuhiko Tsunoda, Hiroyuki Unoki, Koichi Kawai, Masahito Imanishi, Daisuke Suzuki, Hyoung Doo Shin, Kyong Soo Park, Atsunori Kashiwagi, Yasuhiko Iwamoto, Kohei Kaku, Ryuzo Kawamori, Hans-Henrik Parving, Donald W Bowden, Oluf Pedersen, Yusuke Nakamura   +30 more
doaj   +1 more source

“Hard Core” Acetyl Coenzyme‐A Carboxylase

The FASEB Journal, 2015
Diseases involving unregulated cell reproduction, (i.e. cancer) can be inhibited through acetyl coenzyme‐A carboxylase (ACC) manipulation, preventing the lipid production that is imperative for cell survival. ACC catalyzes the first step in the fatty acid biosynthesis. ACC contains two dimers, biotin carboxylase (BC) and carboxyltransferase (CT), and a
Chris Elniff, Dayana Bernardi, Nina Boonyasiti, Ahadou Derib‐Adugna, Alana Einspahr, Sahiba Grover, Namratha Kandru, Nathan Lux, Sai Marre, Jansher Dhillon, Kyra Duong, Herra Hameedi, Julissa Razo, Laura Fogt, Aron Fenton   +14 more
openaire   +1 more source