Results 51 to 60 of about 118,012 (240)

Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland

, 2005
We have developed a mouse model of diet-induced obesity that shows numerous abnormalities relating to mammary gland function. Animals ate 40% more calories when offered a high-fat diet and gained weight at three times the rate of controls. They exhibited
Kelly, Paul A., Flint, David J., Travers, Maureen T., Barber, Michael C., Binart, Nadine, Travers, M., Barber, M.C., Flint, D.J., Kelly, P.A., Binart, N.   +9 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

THE PURIFICATION AND PROPERTIES OF ACETYL-COENZYME A CARBOXYLASE KINASE

, 1982
Acetyl-CoA carboxylase kinase has been purified to apparent homogeneity from rat liver. The kinase was found to exist in two forms: bound to carboxylase in a complex or in a free form that is in different stages of aggregation over a wide range of ...
LENT, BRUCE ALAN
core  

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Acetyl Coenzyme A Synthesis from Unnatural Methylated Corrinoids:  Requirement for “Base-Off” Coordination at Cobalt

, 2016
Acetyl Coenzyme A Synthesis from Unnatural Methylated Corrinoids:  Requirement for “Base-Off” Coordination at ...
Stephen W. Ragsdale (1264635), Javier Seravalli (1264638), Kenneth L. Brown (2168224)   +2 more
core   +1 more source

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source

Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1‐Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma

Exploration, EarlyView.
SGO2 interacts with BRCA1 to inhibit BRCA1 ubiquitination and degradation, thereby promoting BRCA1‐induced DNA damage repair signaling and reducing the chemo sensitivity of LUADa. OA targets glycolysis to disrupt H3K18la‐ and H3K27ac‐mediated chromatin accessibility, repressing SGO2 transcription and subsequently alleviating SGO2‐mediated cancer ...
Xian Lin, Zhidan Hua, Chen Liu, Minxia Yang, Beilei Zhang, Xiaofeng Zhu, Xiao Chen   +6 more
wiley   +1 more source

S as a measure of biological relevance for the N-acetyltransferase Gna1 bound either to coenzyme A (CoA) (pdb: 4ag7; 1.55 Å) or to both CoA and N-acetyl-D-glucosamine-6-phosphate (GlcNAc-6P) (pdb: 4ag9; 1.76 Å).

, 2019
S as a measure of biological relevance for the N-acetyltransferase Gna1 bound either to coenzyme A (CoA) (pdb: 4ag7; 1.55 Å) or to both CoA and N-acetyl-D-glucosamine-6-phosphate (GlcNAc-6P) (pdb: 4ag9; 1.76 Å).
Andrew F. Neuwald (9828), Stephen F. Altschul (245577)   +1 more
core   +1 more source

Light‐Driven Butyrate Production by a Probiotic Clostridium tyrobutyricum Enabled by a Cell‐Semiconductor Hybrid Interface

Food Chemistry International, EarlyView.
This schematic illustrates a light‐driven biohybrid system where CdS nanoparticles, mineralized on the probiotic Clostridium tyrobutyricum, inject photoelectrons to elevate intracellular NADH. This boosts the flux through key NADH‐dependent enzymes (GapA, Hbd, and Bcd), reprogramming metabolism to enhance butyrate yield by 33.2% and selectivity to 95.7%
Qianru Zhao, Zhihan Yang, Bowen Shen, Ling Jiang   +3 more
wiley   +1 more source

Structure, activity, and inhibition of the carboxyltransferase beta-Subunit of acetyl coenzyme a carboxylase (AccD6) from mycobacterium tuberculosis [PDF]

, 2014
In Mycobacterium tuberculosis, the carboxylation of acetyl coenzyme A (acetyl-CoA) to produce malonyl-CoA, a building block in long-chain fatty acid biosynthesis, is catalyzed by two enzymes working sequentially: a biotin carboxylase (AccA) and a ...
Sherekar, Mukul, Breda, A., Bruning, J., Sacchettini, J., Reddy, M., Sherekar, M., Ehrenfeld, H., Ehrenfeld, Hannah, Thurman, Cory, Valluru, S., Reddy, Manchi, Thurman, C., Valluru, Spandana, Breda, Ardala, Bruning, John, Sacchettini, James   +15 more
core   +1 more source