Results 1 to 10 of about 2,085,232 (303)

Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood

Genes and Diseases, 2019
Overfeeding in early life is associated with obesity and insulin resistance in adulthood. In the present study, a well-characterized mouse model was used to investigate whether neonatal overfeeding increases susceptibility to the development of non ...
Juan Du, Xuemei Cao, Junlin Diao, Qijuan Zhang, Chuan Peng, Jibin Li, Xiaoqiu Xiao   +6 more
doaj   +1 more source

TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis

Nature Communications, 2023
Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an important regulator of the thermogenic capacity of brown adipocytes.
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi   +11 more
doaj   +1 more source

Exploring sex bias in cardiometabolic diseases

Lipids in Health and Disease
Cardiometabolic diseases (CMDs), such as cardiovascular diseases (CVDs), obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis (MASH), represent an alarming burden on healthcare systems. Differences in the prevalence, progression
Tania Guillemette, David Rhainds, Océane Robert, Catherine Mounier   +3 more
doaj   +1 more source

Comparison of deuterated leucine, valine, and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics

Journal of Lipid Research, 1990
The production rates of apolipoprotein (apo)B-100 in very low density lipoprotein and in low density lipoprotein and apolipoprotein A-I in high density lipoprotein were determined using a primed-constant infusion of [5,5,5,-2H3]leucine, [4,4,4,-2H3 ...
AH Lichtenstein, JS Cohn, DL Hachey, JS Millar, JM Ordovas, EJ Schaefer   +5 more
doaj   +1 more source

Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells

BMC Genomics
Diabetes cell replacement therapy has the potential to be transformed by human pluripotent stem cell-derived β cells (SC-β cells). However, the precise identity of SC-β cells in relationship to primary fetal and adult β-cells remains unclear.
Mason D. Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman   +3 more
doaj   +1 more source

Apolipoprotein C-III displacement of apolipoprotein E from VLDL: effect of particle size

Journal of Lipid Research, 1999
ApoC-III and apoE are important determinants of intravascular lipolysis and clearance of triglyceride-rich chylomicrons and VLDL from the blood plasma.
Emelita D. Breyer, Ngoc-Anh Le, Xianzhou Li, Deborah Martinson, W. Virgil Brown   +4 more
doaj   +1 more source

Psychological flexibility patterns in patients with type 2 diabetes mellitus and its associations with self-care behavior and medical condition

BMC Psychology
Background This study aimed to elucidate the relationships of psychological flexibility (PF) patterns in patients with type 2 diabetes mellitus with physiological and lifestyle indexes.
Taiki Shima, Aiko Ohya, Hisashi Makino, Yoko Omura-Ohata, Tamiko Tamanaha, Mayu Tochiya, Ryo Koezuka, Masaki Matsubara, Tsutomu Tomita, Michio Noguchi, Yuka Munemoto, Miki Nishimura, Kiminori Hosoda   +12 more
doaj   +1 more source

Impact of age on the metabolism of VLDL, IDL, and LDL apolipoprotein B-100 in men.

Journal of Lipid Research, 1995
Levels of plasma very low density lipoprotein (VLDL) and low density lipoprotein (LDL) constituents increase with age. In an attempt to further define the mechanisms responsible for these changes, kinetic studies of VLDL and LDL apolipoprotein (apo) B ...
J.S. Millar, A.H. Lichtenstein, M. Cuchel, G.G. Dolnikowski, D.L. Hachey, J.S. Cohn, E.J. Schaefer   +6 more
doaj   +1 more source

A new era of secreted phospholipase A2

Journal of Lipid Research, 2015
Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca2+-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.
Makoto Murakami, Hiroyasu Sato, Yoshimi Miki, Kei Yamamoto, Yoshitaka Taketomi   +4 more
doaj   +1 more source

Secreted phospholipase A2 and mast cells

Allergology International, 2015
Phospholipase A2s (PLA2s) are a group of enzymes that hydrolyze the sn-2 position of phospholipids to release (typically unsaturated) fatty acids and lysophospholipids, which serve as precursors for a variety of bioactive lipid mediators.
Makoto Murakami, Yoshitaka Taketomi
doaj   +1 more source